529-0241-10L Advanced Methods and Strategies in Synthesis
|Semester||Autumn Semester 2018|
|Lecturers||J. W. Bode|
|Periodicity||yearly recurring course|
|Language of instruction||English|
|Abstract||Advanced Modern Methods and Strategies in Synthesis|
|Objective||Knowledge of modern methods in asymmetric stereocontrol, enantioselective catalysis, and organic reaction mechanisms.|
|Content||Current trends in methods for and approaches to synthesis of complex natural products, pharmaceuticals, and biological molecules; fragment coupling and protecting group strategies; chemical ligation and biomolecules synthesis; enantioselective catalysis including ligand design and optimization; cross coupling reactions from preactivated precursors; C-H activation and oxidation chemistry; building block synthesis with chiral auxiliaries and reagents; new concepts in asymmetric catalysis. Analysis of key primarily literature including identification of trends, key precendents, and emerging topics will be emphasized.|
|Lecture notes||will be provided in class and online|
1. Walsh and Kozlowski, Fundamentals of Asymmetric Catalysis, 1st Ed., University Science Books, 2009.
2. Anslyn and Dougherty, Modern Physical Organic Chemistry, 1st Ed., University Science Books, 2006.