751-8003-00L Genetics in Agricultural Sciences
Semester | Autumn Semester 2018 |
Lecturers | H. Pausch, B. Studer |
Periodicity | yearly recurring course |
Language of instruction | German |
Comment | Only for Agricultural Sciences BSc. |
Abstract | Important concepts from population, quantitative and molecular genetics are introduced and applied to plant and animal populations. |
Objective | After the course, the students will be able to - work with genetic polymorphisms and explain mechanisms underlying allele frequency changes in natural and experimental populations; - determine factors affecting the selection intensity - explain the difference between genotypic and phenotypic values - quantify the expected genetic gain per time unit - explain important molecular methods to determine genetic polymorphisms; - map traits in plant and animal populations using molecular marker information; - integrate different concepts from population, molecular and quantitative genetics and explain their importance for applications in genetics in agricultural sciences. |
Content | Population genetics (30%) - Allele- and genotype frequencies in populations - Hardy-Weinberg equilibrium - Genetic drift, differentiation of populations - Inbreeding, relationship, effective population size Quantitative genetics (20 %) - Forms of selection and selection differential - Heritability - Quantification of expected genetic gain - Basics of breeding value estimation and properties of estimated breeding values Molecular genetics (35 %) - DNA sequence variation - Marker technologies (SSR, AFLPs, DArT) - Genotyping techologies (KASP, GBS, RADseq, SNP chips) - Recombination, crossing over, linkage analysis, genetic mapping) - QTL mapping Integrative genetics (15%) - Genome-wide association mapping - Estimation of genomic breeding values |
Lecture notes | The slides will be provided in advance of each class via a corresponding Moodle course |
Literature | Further reading: Falconer & Mackay: Introduction to Quantitative Genetics Lübberstedt & Varshney: Diagnostics in Plant Breeding |