Advanced Modern Methods and Strategies in Synthesis
Objective
Knowledge of modern methods in asymmetric stereocontrol, enantioselective catalysis, and organic reaction mechanisms.
Content
Current trends in methods for and approaches to synthesis of complex natural products, pharmaceuticals, and biological molecules; fragment coupling and protecting group strategies; chemical ligation and biomolecules synthesis; enantioselective catalysis including ligand design and optimization; cross coupling reactions from preactivated precursors; C-H activation and oxidation chemistry; building block synthesis with chiral auxiliaries and reagents; new concepts in asymmetric catalysis. Analysis of key primarily literature including identification of trends, key precendents, and emerging topics will be emphasized.
Lecture notes
will be provided in class and online
Literature
Suggesting Textbooks 1. Walsh and Kozlowski, Fundamentals of Asymmetric Catalysis, 1st Ed., University Science Books, 2009. 2. Anslyn and Dougherty, Modern Physical Organic Chemistry, 1st Ed., University Science Books, 2006.
Performance assessment
Performance assessment information (valid until the course unit is held again)
Performance assessment as a semester course