529-0042-00L  Structure Elucidation by NMR

SemesterSpring Semester 2018
LecturersM.‑O. Ebert
Periodicityyearly recurring course
Language of instructionEnglish


AbstractStructure Elucidation of Complex Organic Molecules by NMR
ObjectiveStructure elucidation of complex organic molecules (including peptides, oligosaccharides and oligonucleotides) by advanced 1D and 2D NMR spectroscopy. The emphasis of the course is on the selection of optimal strategies for the solution of a given problem, spectrum interpretation and possible artifacts. Solving and discussing practical case studies/problems demonstrating the individual methods and, in the last third of the course, the combined application of several methods form an important part of the course.
ContentStructure determination by multi-pulse and 2D NMR spectroscopy. Homonuclear and heteronuclear shift correlation through scalar coupling; one and two dimensional methods based on the nuclear Overhauser effect. Choosing the best strategy for a given problem, interpretation and artefacts.
Lecture notesScripts (in English) are distributed in the course
LiteratureT.D.W. Claridge, High Resolution NMR Techniques in Organic Chemistry, Pergamon Press, 1999 (NMR part)
Further reading and citations are listed in the script.
Prerequisites / NoticeThe course language is English.
Required level:
Courses in analytical chemistry of the 2nd year or equivalent.