376-1620-00L  Skeletal Repair

SemesterFrühjahrssemester 2018
DozierendeS. Grad, D. Eglin, F. Moriarty, M. Stoddart
Periodizitätjährlich wiederkehrende Veranstaltung
LehrspracheEnglisch
KommentarMaximale Teilnehmerzahl: 45

Nur für Gesundheitswissenschaften und Technologie MSc und Biomedical Engineering MSc.



Lehrveranstaltungen

NummerTitelUmfangDozierende
376-1620-00 GSkeletal Repair
2 day block course (practical work)
06.-07.04.2018, AO Center Davos
3 Std.
Fr13:15-15:00ML F 38 »
S. Grad, D. Eglin, F. Moriarty, M. Stoddart

Katalogdaten

KurzbeschreibungThe course gives an introduction into traumatic and degenerative pathologies of skeletal tissues. Emphasis is put on bone, cartilage and intervertebral disc. Established and new treatments are described, including cell, gene and molecular therapy, biomaterials, tissue engineering and infection prevention. In vitro/in vivo models are explained.
LernzielThe objectives of this course are to acquire a basic understanding of
(1) important pathologies of skeletal tissues and their consequences for the patient and the public health
(2) current surgical approaches for skeletal repair, their advantages and drawbacks
(3) recent advances in biological strategies for skeletal repair, such as (stem) cell therapy, gene therapy, biomaterials and tissue engineering
(4) pathology, prevention and treatment of implant associated infections
(5) in vitro and in vivo models for basic, translational and pre-clinical studies
InhaltAccording to the expected background knowledge, the cellular and extracellular composition and the structure of the skeletal tissues, including bone, cartilage, intervertebral disc, ligament and tendon will briefly be recapitulated. The functions of the healthy tissues and the impact of acute injury (e.g. bone fracture) or progressive degenerative failure (e.g. osteoarthritis) will be demonstrated. Physiological self-repair mechanisms, their limitations, and current (surgical) treatment options will be outlined. Particular emphasis will be put on novel approaches for biological repair or regeneration of critical bone defects, damaged hyaline cartilage of major articulating joints, and degenerative intervertebral disc tissues. These new treatment options include autologous cell therapies, stem cell applications, bioactive factors, gene therapy, biomaterials or biopolymers; while tissue engineering / regenerative medicine is considered as a combination of some of these factors. In vitro bioreactor systems and in vivo animal models will be described for preclinical testing of newly developed materials and techniques. Bacterial infection as a major complication of invasive treatment will be explained, covering also established and new methods for its effective inhibition. Finally, the translation of new therapies for skeletal repair from the laboratory to the clinical application will be illustrated by recent developments.
Voraussetzungen / BesonderesBasic knowledge in the cellular and molecular composition, structure and function of healthy skeletal tissues, especially bone, cartilage and intervertebral disc are required; furthermore, basic understanding of biomaterial properties, cell-surface interactions, and bacterial infection are necessary to follow this course.

Leistungskontrolle

Information zur Leistungskontrolle (gültig bis die Lerneinheit neu gelesen wird)
Leistungskontrolle als Semesterkurs
ECTS Kreditpunkte3 KP
PrüfendeS. Grad, D. Eglin, F. Moriarty, M. Stoddart
Formbenotete Semesterleistung
PrüfungsspracheEnglisch
RepetitionRepetition nur nach erneuter Belegung der Lerneinheit möglich.

Lernmaterialien

Keine öffentlichen Lernmaterialien verfügbar.
Es werden nur die öffentlichen Lernmaterialien aufgeführt.

Gruppen

Keine Informationen zu Gruppen vorhanden.

Einschränkungen

PlätzeMaximal 45
VorrangDie Belegung der Lerneinheit ist nur durch die primäre Zielgruppe möglich
Primäre ZielgruppeBiomedical Engineering MSc (238000)
Gesundheitswissenschaften und Technologie MSc (380000)
WartelisteBis 05.03.2018

Angeboten in

StudiengangBereichTyp
Biomedical Engineering MasterWahlfächer der VertiefungWInformation
Biomedical Engineering MasterWahlfächer der VertiefungWInformation
Gesundheitswissenschaften und Technologie MasterWahlfächer IIWInformation
Gesundheitswissenschaften und Technologie MasterWahlfächer IIWInformation