Structural principles, nomenclature and different classes of glycosylation. The different pathways of N- and O-linked protein glycosylation and glycolipid biosynthesis in prokaryotes and eukaryotes are discussed. Specific glycan binding proteins and their role in deciphering the glycan code are presented. The role of glycans in infectious diseases, antigen mimicry and autoimmunity are discussed.
Learning objective
Detailed knowledge in 1) the different areas of prokaryotic and eukaryotic glycobiology, in particular in the biosynthesis of glycoproteins and glycolipids, 2) the cellular machinery required for these pathways, 3) the principles of carbohydrate/protein interaction, 4) the function of lectins, 5) the role of glycans in infectious disease.
Content
Structure and linkages; analytical approaches; N-linked protein glycosylation (ER, Golgi); glycan-assisted protein folding and quality control; O-linked protein glycosylation; glucosaminoglycans; glycolipids; prokaryotic glycosylation pathways; lectins; glycans and infectious disease
Lecture notes
handouts
Literature
Introduction to Glycobiology; M.E.Taylor, K.Drickamer, Oxford University Press, 2003 Essentials of Glycobiology (second edition); A.Varki et al. Cold Spring Harbor Laboratory Press, 2009
Prerequisites / Notice
The course will be in English. It will include the preparation of short essays (marked) about defined topics in Glycobiology.
Performance assessment
Performance assessment information (valid until the course unit is held again)
The performance assessment is offered every session. Repetition possible without re-enrolling for the course unit.
Mode of examination
oral 30 minutes
Additional information on mode of examination
Die Leistungskontrollen können in Englisch oder Deutsch absolviert werden. Während des Semester wird eine schriftliche Facharbeit (Umfang 2 A4 Seiten) zu einem gegebenen Thema erstellt. Diese Arbeit wird benotet. Die Gesamtnote errechnet sich aus der Note für schriftlichen Facharbeit (1/3) und der Note der mündlichen Prüfung (2/3).
This information can be updated until the beginning of the semester; information on the examination timetable is binding.
Learning materials
No public learning materials available.
Only public learning materials are listed.
Groups
No information on groups available.
Restrictions
There are no additional restrictions for the registration.
Performance assessment as a semester course