529-0042-00L Structure Elucidation by NMR
| Semester | Spring Semester 2023 |
| Lecturers | M.‑O. Ebert |
| Periodicity | yearly recurring course |
| Language of instruction | English |
| Abstract | Structure Elucidation of Complex Organic Molecules by NMR | ||||||||||||||||||||||||
| Learning objective | Structure elucidation of complex organic molecules (including peptides, oligosaccharides and oligonucleotides) by advanced 1D and 2D NMR spectroscopy: Finding the constitution, rel. configuration and the conformation of an unkown molecule. The emphasis of the course is on the selection of optimal strategies for the solution of a given problem. Discussing and solving these problems by the combined application of various 2D methods form an important part of the course. This also includes the use of state-of-the-art methods for computer assisted structure elucdation (CASE) and chemical shift prediction. | ||||||||||||||||||||||||
| Content | Important experiments for structure elucidation. Finding the optimal strategy for a given problem. Spectral processing for optimal results. Spectral interpretation. Assignment strategies for complex molecules. Common Artefacts. Computer assisted structure elucidation incl. introduction to relevant software and hands-on application. Chemical shift prediction. Discussion of challenging problem sets during class. | ||||||||||||||||||||||||
| Lecture notes | Scripts (in English) are distributed in the course | ||||||||||||||||||||||||
| Literature | "T.D.W. Claridge, High Resolution NMR Techniques in Organic Chemistryî, Pergamon Press, 1999. (NMR Teil) Further reading and citations are listed in the script. | ||||||||||||||||||||||||
| Prerequisites / Notice | The course language is English. Required level: Courses in analytical chemistry of the 2nd year or equivalent. | ||||||||||||||||||||||||
Competencies |
|