535-0041-00L Pharmacology and Toxicology III

Semester	Autumn Semester 2020
Lecturers	M. Detmar, U. Quitterer, A. Langer
Periodicity	yearly recurring course
Language of instruction	English

Abstract	The course is divided into two parts. The first part provides a detailed understanding of drugs and pharmacotherapy of infectious diseases and cancer. The second part gives an overview of the field of pharmacogenomics with a special focus on the role of genetic polymorphisms in disease susceptibility, drug response and adverse effects.
Learning objective	The course advances basic knowledge in pharmacology and toxicology. Special emphasis is placed on the interrelationship between pharmacological, pathophysiological and clinical aspects of drug therapy in the fields of infectious diseases and cancer. The course also provides an overview of the field of pharmacogenomics, with a special focus on the role of genetic polymorphisms in disease susceptibility, drug response and adverse effects.
Content	Topics include the pharmacology and pharmacotherapy of infectious diseases and cancer. In the field of pharmacogenomics, the course is focused on genetics, genome-wide association studies, genetic disease predisposition, examples of genetic variability of drug metabolism and drug responses, identification of new drug targets, relevance of pharmacogenomics for clinical drug development, and toxicogenomics.
Lecture notes	A script is provided for each lecture course. The scripts define important and exam-relevant contents of lectures. Scripts do not replace the lecture.
Literature	Recommended reading: The classic textbook in Pharmacology: Goodman and Gliman`s The Pharmacological Basis of Therapeutics Laurence Brunton, Bjorn Knollman, Randa Hilal-Dandan. 13th edition (2017) ISBN-10: 1259584739 ISBN-13: 978-1259584732 or Klaus Aktories, Ulrich Förstermann, Franz Hofmann, Klaus Starke. Allgemeine und spezielle Pharmakologie und Toxikologie. 12th edition (2017) Urban & Fischer (Elsevier, München) ISBN-13: 978-3-437-42527-7