535-0240-00L  Laboratory Course in Biopharmacy

SemesterSpring Semester 2020
LecturersS.‑D. Krämer
Periodicityyearly recurring course
Language of instructionGerman


AbstractExperimental determination of pharmacokinetic parameters in vitro: biotransformation experiments (phase I and II) with rat liver microsomes; determination of partition coefficients in the octanol/buffer system including stability testing; protein binding and displacement studies with bovine serum albumin as binding partner.
Learning objectiveConsolidation and implementation of the lecture "Biopharmazie" (535-0241-00 V).
ContentExperimental determination of pharmacokinetic parameters in vitro: biotransformation experiments (phase I and II) with pork liver microsomes; determination of partition coefficients in the octanol/buffer system including stability testing; protein binding and displacement studies with bovine serum albumin as binding partner.
Lecture notesBiopharmazie Praktikumsskript (Krämer/Wunderli-Allenspach)
LiteratureP. Langguth, G. Fricker, H. Wunderli-Allenspach "Biopharmazie", Wiley-VCH Verlag, Weinheim, 2004
Prerequisites / NoticeRequirements:
Laboratory course in Pharmaceutical Analytics passed
Lecture in Biopharmacy in the same semester or previously