751-8003-00L  Genetics in Agricultural Sciences

SemesterAutumn Semester 2018
LecturersH. Pausch, B. Studer
Periodicityyearly recurring course
Language of instructionGerman
CommentOnly for Agricultural Sciences BSc.

AbstractImportant concepts from population, quantitative and molecular genetics are introduced and applied to plant and animal populations.
ObjectiveAfter the course, the students will be able to
- work with genetic polymorphisms and explain mechanisms underlying allele frequency changes in natural and experimental populations;
- determine factors affecting the selection intensity
- explain the difference between genotypic and phenotypic values
- quantify the expected genetic gain per time unit
- explain important molecular methods to determine genetic polymorphisms;
- map traits in plant and animal populations using molecular marker information;
- integrate different concepts from population, molecular and quantitative genetics and explain their importance for applications in genetics in agricultural sciences.
ContentPopulation genetics (30%)
- Allele- and genotype frequencies in populations
- Hardy-Weinberg equilibrium
- Genetic drift, differentiation of populations
- Inbreeding, relationship, effective population size
Quantitative genetics (20 %)
- Forms of selection and selection differential
- Heritability
- Quantification of expected genetic gain
- Basics of breeding value estimation and properties of estimated breeding values
Molecular genetics (35 %)
- DNA sequence variation
- Marker technologies (SSR, AFLPs, DArT)
- Genotyping techologies (KASP, GBS, RADseq, SNP chips)
- Recombination, crossing over, linkage analysis, genetic mapping)
- QTL mapping
Integrative genetics (15%)
- Genome-wide association mapping
- Estimation of genomic breeding values
Lecture notesThe slides will be provided in advance of each class via a corresponding Moodle course
LiteratureFurther reading:
Falconer & Mackay: Introduction to Quantitative Genetics
Lübberstedt & Varshney: Diagnostics in Plant Breeding