626-0002-AAL  Bioinformatics

SemesterAutumn Semester 2016
LecturersJ. Stelling, N. Beerenwinkel
Periodicityevery semester recurring course
Language of instructionEnglish
CommentEnrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement.

Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit.


626-0002-AA RBioinformatics
Self-study course. No presence required.
120s hrsJ. Stelling, N. Beerenwinkel

Catalogue data

AbstractThe course introduces concepts of bioinformatics starting from first principles: DNA sequence alignment, phylogenetic tree inference, genome annotation, protein structure and function prediction. Key methods and algorithms are covered, including dynamic programming, Markov and Hidden Markov models, and molecular dynamics simulations. Practical applications and limitations are discussed.
ObjectiveThe course aims at introducing the fundamental concepts and methods of bioinformatics. Emphasis is given to a deep understanding of the methods' foundations and limitations to enable critical evaluations and applications of bioinformatics tools in areas such as biotechnology and systems biology.
ContentFrom "Understanding Bioinformatics":
Chapter 4: Producing and Analyzing Sequence Alignments
Chapter 5: Pairwise Sequence Alignment and Database Searching
Chapter 6: Patterns, Profiles, and Multiple Alignments
Chapter 7: Recovering Evolutionary History
Chapter 8: Building Phylogenetic Trees
Chapter 9: Revealing Genome Features
Chapter 10: Gene Detection and Genome Annotation
Chapter 11: Obtaining Secondary Structure from Sequence
Chapter 12: Predicting Secondary Structures
Chapter 13: Modeling Protein Structure
Chapter 14: Analyzing Structure-Function Relationships

From "Biological Sequence Analysis":
Sections 3.1, 3.2, 3.3, 4.1, 4.2, 4.4, 5.2, 5.3, 5.4, 6.5 (Markov Chains and Hidden Markov Models)

From "A First Course in Systems Biology":
Chapter 1: Biological Systems
Lecture notesCourse material will be made available at: Link
LiteratureZvelebil M, Baum JO. Understanding Bioinformatics. Garland Science, 2008.
Durbin R, Eddy S, Krogh A, Mitchinson G. Biological Sequence Analysis. Cambridge University Press, 2004.
Voit EO. A First Course in Systems Biology. Garland Science, 2012.
Prerequisites / NoticeThere will be two opportunities for tutorials during the semester


Performance assessment

Performance assessment information (valid until the course unit is held again)
Performance assessment as a semester course
ECTS credits4 credits
ExaminersJ. Stelling, N. Beerenwinkel
Typesession examination
Language of examinationEnglish
RepetitionThe performance assessment is offered every session. Repetition possible without re-enrolling for the course unit.
Mode of examinationoral 30 minutes
This information can be updated until the beginning of the semester; information on the examination timetable is binding.

Learning materials

No public learning materials available.
Only public learning materials are listed.


No information on groups available.


There are no additional restrictions for the registration.

Offered in

Biotechnology MasterCourse Units for Additional Admission RequirementsE-Information