752-1300-00L  Introduction to Molecular Toxicology

SemesterSpring Semester 2015
LecturersS. J. Sturla
Periodicityyearly recurring course
Language of instructionEnglish


AbstractIntroduction to chemical and biological interactions that govern the properties, disposition and biological influences of toxins.
Learning objectiveThe objectives are for the student to establish a framework for examining adverse effects resulting from exposures to toxins by understanding key molecular mechanisms that give rise to toxic responses and disease processes.
ContentThis course will introduce mechanisms governing the chemical disposition and biological influences of toxins. The course is suitable for advanced bachelors, or beginning masters or PhD students, in food science and related disciplines (i.e. chemistry, environmental sciences, pharm sciences, etc.) Examples of topics include: dose-response relationships and risk assessment, absorption, transport, and biotransformation of xenobiotic chemicals; Carcinogenesis; DNA damage, repair, and mutation; Chemotherapy; Immunotoxicity; Neurotoxicity; Systems Toxicology. These fundamental concepts in Molecular Toxicology will be integrated with examples of toxicants relevant to food, drugs and the environment.
LiteratureCasarett & Doull's Essentials of Toxicology, Second Edition. Curtis Kaassen and John B. Watkins III, 2010, McGraw-Hill.
Prerequisites / Noticeorganic chemistry and biochemistry