401-6282-00L  Statistical Analysis of High-Throughput Genomic and Transcriptomic Data (University of Zurich)

SemesterHerbstsemester 2021
DozierendeH. Rehrauer, M. Robinson
Periodizitätjährlich wiederkehrende Veranstaltung
LehrspracheEnglisch
KommentarDer Kurs muss direkt an der UZH als incoming student belegt werden.
UZH Modulkürzel: STA426

Beachten Sie die Einschreibungstermine an der UZH:
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KurzbeschreibungA range of topics will be covered, including basic molecular biology, genomics technologies and in particular, a wide range of statistical and computational methods that have been used in the analysis of DNA microarray and high throughput sequencing experiments.
Lernziel-Understand the fundamental "scientific process" in the field of Statistical Bioinformatics
-Be equipped with the skills/tools to preprocess genomic data (Unix, Bioconductor, mapping, etc.) and ensure reproducible research (Sweave)
-Have a general knowledge of the types of data and biological applications encountered with microarray and sequencing data
-Have the general knowledge of the range of statistical methods that get used with microarray and sequencing data
-Gain the ability to apply statistical methods/knowledge/software to a collaborative biological project
-Gain the ability to critical assess the statistical bioinformatics literature
-Write a coherent summary of a bioinformatics problem and its solution in statistical terms
InhaltLectures will include: microarray preprocessing; normalization; exploratory data analysis techniques such as clustering, PCA and multidimensional scaling; Controlling error rates of statistical tests (FPR versus FDR versus FWER); limma (linear models for microarray analysis); mapping algorithms (for RNA/ChIP-seq); RNA-seq quantification; statistical analyses for differential count data; isoform switching; epigenomics data including DNA methylation; gene set analyses; classification
SkriptLecture notes, published manuscripts
Voraussetzungen / BesonderesPrerequisites: Basic knowlegde of the programming language R, sufficient knowledge in statistics

Former course title: Statistical Methods for the Analysis of Microarray and Short-Read Sequencing Data