Jörg Scheuermann: Catalogue data in Autumn Semester 2020
|Name||PD Dr. Jörg Scheuermann|
Inst. f. Pharmazeutische Wiss.
ETH Zürich, HCI G 396.4
|Telephone||+41 44 633 77 74|
|Fax||+41 44 633 13 58|
|Department||Chemistry and Applied Biosciences|
|511-0000-00L||Drug Discovery and Development |
Only for Pharmaceutical Sciences MSc.
|2 credits||2G||U. Thibaut, K.‑H. Altmann, J. Hall, J.‑C. Leroux, J. Scheuermann, G. Schneider|
|Abstract||This course provides an overview over the concepts and processes employed in today's drug discovery and development. It has an introductory character but will also provide more detailed insights employing real life examples. The course combines lectures and interactive elements with active participation of the students.|
- Understand the drug discovery process and can explain major approaches and relevant technical terms (for details see lecture notes).
- Understand and appreciate the content and timing of drug development process steps, development phases and decision criteria.
- Understand the concepts underlying drug product development through all the phases from preclinical and clinical development to regulatory submission, approval and market launch.
- Can differentiate between small molecule drug development and biological drug development.
- Understand the most important differences between legal and regulatory requirements for drug development and approval for the major markets EU and USA.
|Content||Drug Discovery (day 1):|
Introduction to drug discovery: the concepts of drug target selection, ligands/leads, the developability of drug candidates;
Overview over the principal approaches to drug discovery: rational drug design, the natural product approach, serendipity, repurposing as well as chemical libraries and high-throughput screening.
Drug Development (day 2)
Introduction to development processes from the perspective of the pharmaceutical industry. Why and how are decisions for drug development candidates made? What drives portfolio decisions of pharmaceutical companies? Besides stimulating lectures, the course also includes group work on interesting new drugs both from the class of small molecules as well as from biologicals.
Drug Development (days 3 and 4):
Introduction to the entire suite of drug product development processes in the pharmaceutical industry, covering the following phases: preclinical research and development, clinical development, regulatory processes and market launch.
R&D support processes such as project management, quality management, pharmacovigilance and pharmacoeconomics will be covered as well as organizational and governance aspects of the pharmaceutical industry.
In addition, important success factors for a later career in the pharmaceutical industry will be discussed and highlighted at the end of the course.
|Lecture notes||Will be published on "mystudies"|
|Literature||G. Nahler (Hrsg.) Dictionary of pharmaceutical medicine, Springer, Wien, 2013 (3rd edition)|
Further readings will be listed in the lecture notes.
|Prerequisites / Notice||This course provides the essential basic knowledge required for the industry-specific modules of the spring semester.|
|511-1003-00L||Gene Technology (Crash Course) |
Only for Pharmaceutical Sciences MSc.
Obligatory course if assigned by the Admission committee.
|1 credit||1S||J. Scheuermann|
|Abstract||The course enables the student to understand and and apply the general concepts of gene technology, including recombinant DNA technology and its application in genomics, transcriptomics and proteomics. Protein cloning, expression and modifications and bimolecular interactions will be discussed. The concept of display technology and its applications in the field of drug discovery will be presented.|
|Objective||The students remember and understand:|
1. The tools of recombinant DNA technology
2. Next generation sequencing approaches and their relevance for -omics projects
3. Protein cloning, expression, modification/labelling and oligomerization
4. Thermodynamic and kinetic affinity constants in bimolecular reactions
5. Basic structure of the antibody molecule
6. Concepts of antibody phage technology and antibody engineering
7. Construction of antibody-, peptide- or small molecule libraries and affintiy-based selection methodologies
recombinant DNA technology
methods to sequence genomes
application to human biology
Transcriptomics / Proteomics
protein cloning and expression
homo- and heterodimerization
chemical modifications and radioactive labelling
detection of bimolecular interactions
affinity constant and experimental measurement
kinetic association and dissociation constants
III) Display technology:
the antibody molecule, CDRs, basics of antibody engineering
antibody phage display and selection methodologies
construction of antibody libraries
other display technologies (peptide display, DNA-encoded chemical libraries)
|Lecture notes||slides and script used for the course and literature for reading and discussions will be made available online.|
|Literature||dedicated chapters of: |
S.B. Primrose and R.M. Twyman 'Principles of Gene Manipulation and Genomics', 7th ed. (2006) Blackwell Science
dedicated articles will be announced
|Prerequisites / Notice||admission to MSc in Pharmaceutical Sciences|
|535-0001-00L||Introduction to Pharmaceutical Sciences I||2 credits||2V||J. Hall, K.‑H. Altmann, A. Burden, M. Detmar, C. Halin Winter, J.‑C. Leroux, C. Müller, U. Quitterer, J. Scheuermann, R. Schibli, G. Schneider, H. U. Zeilhofer|
|Abstract||First identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences, which are focused on within the first two years as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities.|
|Objective||First identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities.|
|Content||Introduction to Pharmaceutical Sciences by selected milestones of research and development. Overview on research activities at the Institute of Pharmaceutical Sciences that is focussed on drug delivery and development (from concepts to prototypes). Sensitization for communication skills and information management. Demonstration of job opportunities in community pharmacies, in the hospital, in industry, and in the public sector by experts in the different fields.|
|Lecture notes||Handouts for individual lectures.|
|Prerequisites / Notice||Interactive teaching|
|535-0239-00L||Practical Course in Medicinal Chemistry||3 credits||7P||J. Hall, M. Detmar, C. Halin Winter, J. Scheuermann|
|Abstract||The course comprises experiments relating to concepts of medicinal chemistry including statistical processing, fitting of experimental data, computer modeling of protein structures, experimental measurement of affinity constants and kinetic dissociation constants for protein ligands. The chemical stability of a drug will be studied. Basic gene cloning and protein expression will be introduced.|
|Objective||Knowledge of experimental methods in drug discovery and development|
|Content||Characterisation of the biophysical and biological properties of drugs.|
|Prerequisites / Notice||Requirements: |
Laboratory course in Pharmaceutical Analytics;
Lecture Medicinal Chemistry I in the same semester or earlier.
|535-0300-00L||Molecular Mechanisms of Drug Actions and Targets |
Number of participants limited to 24.
|2 credits||1V||J. Scheuermann|
|Abstract||On average one drug per year is withdrawn from the market. Using selected examples of such drug failures, the course aims at analyzing and discussing the present explanations of drug actions as well as the design and predictive power of animal models and clinical trials. In addition, the ethical, societal, and economical expectations in new drugs shall be reflected and discussed.|
|Objective||To develop a critical understanding of the relevance and limitations of the current approaches to explaining and anticipating drug effects. To critically appraise the ethical, societal, economical and political expectations in the development of new drugs.|
|Content||In December 2006, Pfizer stopped a large phase III study on the use of Torcetrapib for the prevention of atherosclerosis and cardiovascular disease. 800 million $ in development costs and 21 billion $ in stocks were annihilated overnight. The failure of Torcetrapib has pinpointed the limitations of an extremely reductionist view of atherosclerosis and it's prevention by drug therapy. It has also highlighted what high expectations we have in a safe and wide applicability of drugs and of their economical success. |
Torcetrapib is not a single case. In the last 10 years, on average one drug per year was withdrawn from the market due to lack of efficacy, unexpected side effects or toxicity. This clearly shows that the common investigations and the modern understanding of drug actions are often not sufficient to predict the effects a drug will have in large patient populations.
These are the topics of the present course. Using three particularly informative examples of drug failures, the problems encountered and the concepts and informative value of preclinical and clinical studies will be analyzed and discussed. Furthermore, the ethical, societal, economical and political expectations in new drugs shall be reflected.
|Lecture notes||Lecture slides and literature for reading and discussions will be available online.|
|Prerequisites / Notice||Requirements: basic knowledge in Medicinal Chemistry and Pharmacology. Ability to read and understand scientific publications written in English.|
|535-0810-00L||Gene Technology||2 credits||2G||K. Eyer, J. Scheuermann|
|Abstract||The course gives a description and summary of the field of gene technology and its pharmaceutical applications. The course focuses on important methods and technologies and their application for genomic, transcriptomic and proteomic analyses in human biology.|
|Objective||The course gives an overview of current state-of-the art and advancement in the fields of gene technology. Herein, the course focuses on genomic, transcriptomic and proteomic analysis and their uses in drug discovery and biomedical applications. The course is structured into lectures and practical examples drawn from the research field. Upon completion, the students are familiar and know current state-of-the art of methods and applications, but are also able to classify, contrast and apply different strategies and methods within the field of gene technology. The course is suited for advanced undergraduate and early graduate students in pharmaceutical sciences or related fields.|
|Content||I) Genomics and transcriptomics|
Methods and Techniques:
• Recombinant DNA technology
• Next generation sequencing methods, sequencing of genomes
• CRISPR technology
Application to human biology:
• Functional genomics/transcriptomics
• Principles of cancer, genetic diseases
• Therapies: cell-based therapies/gene therapies/DNA and RNA vaccination
Methods and Techniques:
• Protein cloning and expression
• The antibody molecule
• Measurement and determination of biomolecular interactions
• Protein characterization and engineering
• Modifications and radioactive labelling
Application to human biology:
• Protein therapeutics
• Proteomic approaches for identification of novel disease-related targets and biomarkers
III) Drug discovery: Protein-based libraries
•Immune repertoire mining
•Display and selection technologies
1. antibody phage display
2. other polypeptide display technologies
3. small-molecules display: DNA-encoded chemical libraries