Christian Wolfrum: Catalogue data in Spring Semester 2019

Name	Prof. Dr. Christian Wolfrum
Field	Translational Nutrition Biology
Address	VP Forschung ETH Zürich, HG F 57 Rämistrasse 101 8092 Zürich SWITZERLAND
Telephone	+41 44 632 20 39
E-mail	christian-wolfrum@ethz.ch
Department	Health Sciences and Technology
Relationship	Full Professor and Vice President of Research

Number	Title	ECTS	Hours	Lecturers
376-0004-01L	Lab Introduction to Health Sciences and Technology Only for Health Sciences and Technology BSc.	2 credits	2P	R. Müller, R. Riener, C. Wolfrum
Abstract	Selected experiments in the area of health sciences and technology as introduction to scientific working.
Objective	Students should understand the methods of scientific working which they will apply in various experiments.
376-0006-02L	Laboratory Course in Molecular Biology	2 credits	2P	C. Wolfrum, K. De Bock, C. Ewald, M. Ristow
Abstract	Introduction to experimental molecular biology using physiological examples.
Objective	Practical experience of molecular biology. Learning of fundamental research methods.
Content	Protein analysis , cell culture, quantification of RNA.
Lecture notes	Ein Skript zum Praktikum wird abgegeben.
Prerequisites / Notice	Cell Biology
376-0008-00L	Advanced Anatomy and Physiology II: Advanced Physiology and Pathophysiology Only for Health Sciences and Technology BSc.	4 credits	4V	K. De Bock, O. Bar-Nur, M. Detmar, G. A. Kuhn, M. Ristow, G. Schratt, C. Spengler, C. Wolfrum, M. Zenobi-Wong
Abstract	In-depth theory to molecular and pathophysiological aspects of nerves, muscles, heart , circulatory , respiratory and sensory organs .
Objective	In-depth knowledge of anatomy and physiology.
Content	Molecular fundamentals of physiological processes, processes of disease development.
376-0209-00L	Molecular Disease Mechanisms	6 credits	4V	C. Wolfrum, H. Gahlon, M. Kopf
Abstract	In this course the mechanisms of disease development will be studied. Main topics will be: 1. Influence of environmental factors with an emphasis on inflammation and the immune response. 2. Mechanisms underlying disease progression in metabolic disorders, integrating genetic and environmental factors. 3. Mechanisms underlying disease progression in cancer, integrating genetic and environment
Objective	To understand the mechanisms governing disease development with a special emphasis on genetic and environmental associated components
Lecture notes	All information can be found at: https://moodle-app2.let.ethz.ch/course/view.php?id=690 The enrollment key will be provided by email
377-0405-00L	Fundamentals of Research and Ethics Only for Human Medicine BSc.	5 credits	5V	H. C. Bucher, E. Vayena, C. Wolfrum, A. Blasimme, C. Brall, F. Gille, M. Ienca, further lecturers
Abstract	On the one hand, this module teaches basic knowledge for a critical study of literature with a close relation to clinical decision making as well as the fundamentals of clinical research methodology. On the other hand, methods of personalized medicine and related ethical problems in medical and biomedical research are discussed.
Objective	This module is intended to enable students to critically appreciate scientific literature and to plan clinical trials themselves, and to recognize and analyze ethical controversial situations in everyday medical practice.
Content	The sub-module 'Clinical Research' contains the following aspects: - Basic principles of evidence assessment (validity, clinical relevance and external validity of evidence) on the basis of clinical case vignettes (diagnostics, therapy, screening). - Development and presentation of a clinical trial protocol. The ‘Ethics in Medicine and Health Care’ sub-module contains the following ethical issues: - Doctor-patient relationship - End-of-life decisions - Reproductive choices - Techniques such as genetic testing, genome sequencing, Big Data, Artificial Intelligence The submodule 'Personalized Medicine' contains the following aspects: - Introduction to precision medicine - Mendelian inheritance and monogenic diseases - GWAS and precision medicine - Biomarkers in precision medicine
377-0407-00L	Lab Digital Medicine Only for Human Medicine BSc.	5 credits	6P	C. Wolfrum
Abstract	In this practical course, students will learn about the latest diagnostic and bioinformatics tools to investigate human genetic variations that are at the bases of individual drug responses. Contents include RNA and DNA applications, generation of libraries, sequencing, data interpretation and analysis, public genomic data set investigations with emphasis on cancer genomics “big data”.
Objective	The goal is to get the right knowledge to perform genetic analyses to finally predict as well as to precisely perform as more personal as possible diagnosis and therapies for human diseases.
752-6001-AAL	Introduction to Nutritional Science Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement. Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit.	3 credits	6R	M. B. Zimmermann, C. Wolfrum
Abstract	This course introduces basic concepts of micro- and macronutrient nutrition. Micronutrients studied include fat-soluble and water-soluble vitamins, minerals and trace elements. Macronutrients include proteins, fat and carbohydrates. Special attention is given to nutrient digestion, bioavailability, metabolism and excretion with some focus on energy metabolism.
Objective	To introduce the students to the both macro- and micronutrients in relation to food and metabolism.
Content	The course is devided into two parts. The lectutres on micronutrients are given by Prof. Zimmermann and the lectures on macronutrients are given by Prof. Wolfrum. Prof. Zimmermann discusses the micronutrients, including fat-soluble vitamins, water-soluble vitamins, minerals and trace elements. Prof. Wolfrum introduces basic nutritional aspects of proteins, fats, carbohydrates and energy metabolism. The nutrients are described in relation to digestion, absorption and metabolism. Special aspects of homeostasis and homeorhesis are emphasized.
Literature	Elmadfa I & Leitzmann C: Ernährung des Menschen UTB Ulmer, Stuttgart, 4. überarb. Ausgabe 2004 ISBN-10: 3825280365; ISBN-13: 978-3825280369 Garrow JS and James WPT: Human Nutrition and Dietetics Churchill Livingstone, Edinburgh, 11th rev. ed. 2005 ISBN-10: 0443056277; ISBN-13: 978-0443056277
752-6002-00L	Advanced Topics in Nutritional Science	3 credits	2V	V. Galetti, J. M. Sych, C. Wolfrum
Abstract	The course gives an introduction to dietary recommendations and nutrient requirements at different stages of the life cycle. It also includes lectures on specific diets, e.g. vegetarianism and weight loss, as well as important micronutrients and other food components and their interactions.
Objective	The learning objectives are improved student understanding of: 1) the dietary recommendations and nutrient requirements of populations at different stages of the life cycle; 2) the effect of different diets on health; and 3) certain micronutrients and other nutritionally important food components.
Content	The course gives a brief introduction into different areas of human nutrition. Including: 1) Dietary recommendations and the nutrient requirements at different stages of the life cycle, including pregnancy and lactation, childhood and adolescence, adults and elderly. 2) The influence of specific diets (e.g. vegetarianism, weight loss diets) on health. 3) Specific nutrients (e.g. iron and biological active ingredients) and their interactions.
Lecture notes	The lecture details and teaching slides will be available online