Michael Detmar: Catalogue data in Autumn Semester 2021 |
| Name | Prof. em. Dr. Michael Detmar |
| Field | Pharmacogenomics |
| Address | Inst. f. Pharmazeutische Wiss. ETH Zürich, HCI H 303 Vladimir-Prelog-Weg 1-5/10 8093 Zürich SWITZERLAND |
| Telephone | +41 44 633 73 61 |
| michael.detmar@pharma.ethz.ch | |
| Department | Chemistry and Applied Biosciences |
| Relationship | Professor emeritus |
| Number | Title | ECTS | Hours | Lecturers | |
|---|---|---|---|---|---|
| 535-0001-00L | Introduction to Pharmaceutical Sciences I  | 2 credits | 2V | J. Hall, K.‑H. Altmann, M. Detmar, C. Halin Winter, J.‑C. Leroux, U. Quitterer, J. Scheuermann, R. Schibli, H. U. Zeilhofer | |
| Abstract | First identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences, which are focused on within the first two years as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities. | ||||
| Learning objective | First identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities. | ||||
| Content | Introduction to Pharmaceutical Sciences by selected milestones of research and development. Overview on research activities at the Institute of Pharmaceutical Sciences that is focussed on drug delivery and development (from concepts to prototypes). Sensitization for communication skills and information management. Demonstration of job opportunities in community pharmacies, in the hospital, in industry, and in the public sector by experts in the different fields. | ||||
| Lecture notes | Handouts for individual lectures. | ||||
| Prerequisites / Notice | Interactive teaching | ||||
| 535-0011-00L | Drug Seminar The course is reserved for students registered in the Master's programme in Pharmacy or in Pharmaceutical Sciences | 5 credits | 9S | A. Burden, K.‑H. Altmann, M. Detmar, K. Eyer, C. Halin Winter, J. Hall, S.‑D. Krämer, J.‑C. Leroux, C. Müller, V. I. Otto, U. Quitterer, J. Scheuermann, R. Schibli, C. Steuer | |
| Abstract | The course provides a platform for the investigation, presentation and discussion of a topic with relevance to the field of pharmaceutical sciences. Students work in small groups on a chosen topic, they write a mini-review and present their work on a one day symposium. | ||||
| Learning objective | The main objectives of this course are: - students develop their scientific reflection (Critical Thinking) and working skills by working independently on a relevant pharmaceutical topic - students gain in-depth knowledge of the topic investigated - students train their scientific writing and presentation skills - students train their ability to plan a project and work in a team | ||||
| Content | The Course Drug Seminar takes place during the first 7 weeks of the 1. Master semester. It is a compulsory course of the MSc Pharmacy curriculum and an elective course in the MSc PharmSciences. The course provides a platform for the investigation, presentation and discussion of a topic with relevance to the field of pharmaceutical sciences. During the course, students work in small teams on a topic of their choice and elaborate a written mini-review and an oral presentation. Each team is tutored by a lecturer of the Institute of Pharmaceutical Sciences. The work is mainly based on literature search / review, but may also involve conducting interviews or site visits, if appropriate. The final presentations of all groups will take place in the framework of a dedicated Symposium held in the middle of the semester. | ||||
| Prerequisites / Notice | Only for students of MSc Pharmacy and MSc Pharmaceutical Sciences. | ||||
| 535-0041-00L | Pharmacology and Toxicology III | 2 credits | 2G | M. Detmar, U. Quitterer | |
| Abstract | The course is divided into two parts. The first part provides a detailed understanding of drugs and pharmacotherapy of infectious diseases and cancer. The second part gives an overview of the field of pharmacogenomics with a special focus on the role of genetic polymorphisms in disease susceptibility, drug response and adverse effects. | ||||
| Learning objective | The course advances basic knowledge in pharmacology and toxicology. Special emphasis is placed on the interrelationship between pharmacological, pathophysiological and clinical aspects of drug therapy in the fields of infectious diseases and cancer. The course also provides an overview of the field of pharmacogenomics, with a special focus on the role of genetic polymorphisms in disease susceptibility, drug response and adverse effects. | ||||
| Content | Topics include the pharmacology and pharmacotherapy of infectious diseases and cancer. In the field of pharmacogenomics, the course is focused on genetics, genome-wide association studies, genetic disease predisposition, examples of genetic variability of drug metabolism and drug responses, identification of new drug targets, relevance of pharmacogenomics for clinical drug development, and toxicogenomics. | ||||
| Lecture notes | A script is provided for each lecture course. The scripts define important and exam-relevant contents of lectures. Scripts do not replace the lecture. | ||||
| Literature | Recommended reading: The classic textbook in Pharmacology: Goodman and Gliman`s The Pharmacological Basis of Therapeutics Laurence Brunton, Bjorn Knollman, Randa Hilal-Dandan. 13th edition (2017) ISBN-10: 1259584739 ISBN-13: 978-1259584732 or Klaus Aktories, Ulrich Förstermann, Franz Hofmann, Klaus Starke. Allgemeine und spezielle Pharmakologie und Toxikologie. 12th edition (2017) Urban & Fischer (Elsevier, München) ISBN-13: 978-3-437-42527-7 | ||||
| 535-0239-00L | Practical Course in Medicinal Chemistry | 3 credits | 7P | J. Hall, M. Detmar, C. Halin Winter, J. Scheuermann | |
| Abstract | The course comprises experiments relating to concepts of medicinal chemistry including statistical processing, fitting of experimental data, computer modeling of protein structures, experimental measurement of affinity constants and kinetic dissociation constants for protein ligands. The chemical stability of a drug will be studied. Basic gene cloning and protein expression will be introduced. | ||||
| Learning objective | Knowledge of experimental methods in drug discovery and development | ||||
| Content | Characterisation of the biophysical and biological properties of drugs. | ||||
| Lecture notes | Scripts | ||||
| Literature | Original literature | ||||
| Prerequisites / Notice | Requirements: Laboratory course in Pharmaceutical Anaytics; Lecture Medicinal Chemistry I in the same semester or earlier. Safety conceptt: https://chab.ethz.ch/studium/bachelor1.html | ||||
| 535-0900-00L | Seminars on Drug Discovery and Development | 1 credit | 1K | R. Schibli, K.‑H. Altmann, M. Detmar, K. Eyer, C. Halin Winter, J. Hall, J.‑C. Leroux, U. Quitterer, G. Schneider, H. U. Zeilhofer | |
| Abstract | State-of-the-art information on drug discovery and development by experts from academia and industry. | ||||
| Learning objective | State-of-the-art information on drug discovery and development. | ||||
| Content | Seminar series of the Institute of Pharmaceutical Sciences. Experts from academia and industry report on relevant topics. | ||||
| 551-0509-00L | Current Immunological Research in Zurich | 0 credits | 1K | R. Spörri, M. Detmar, C. Halin Winter, W.‑D. Hardt, M. Kopf, S. R. Leibundgut, A. Oxenius, University lecturers | |
| Abstract | This monthly meeting is a platform for Zurich-based immunology research groups to present and discuss their ongoing research projects. At each meeting three PhD students or Postdocs from the participating research groups present an ongoing research project in a 30 min seminar followed by a plenary discussion. | ||||
| Learning objective | The aim of this monthly meeting is to provide further education for master and doctoral students as well as Postdocs in diverse topics of immunology and to give an insight in the related research. Furthermore, this platform fosters the establishment of science- and technology-based interactions between the participating research groups. | ||||
| Content | Presentation and discussion of current research projects carried out by various immunology-oriented research groups in Zurich. | ||||
| Lecture notes | none | ||||