Stefanie-Dorothea Krämer: Catalogue data in Spring Semester 2020

Award: The Golden Owl
Name Prof. Stefanie-Dorothea Krämer
FieldBiopharmacy
Address
Inst. f. Pharmazeutische Wiss.
ETH Zürich, HCI H 409
Vladimir-Prelog-Weg 1-5/10
8093 Zürich
SWITZERLAND
Telephone+41 44 633 74 03
Fax+41 44 633 14 57
E-mailstefanie.kraemer@pharma.ethz.ch
URLhttp://www.biopharmacy.ethz.ch/
DepartmentChemistry and Applied Biosciences
RelationshipAdjunct Professor and Privatdozentin

NumberTitleECTSHoursLecturers
535-0002-00LIntroduction to Pharmaceutical Sciences II3 credits2VJ. Hall, K.‑H. Altmann, S. M. Ametamey, S.‑D. Krämer, J.‑C. Leroux, D. Neri, U. Quitterer, R. Schibli, C. Steuer
AbstractFirst identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences, which are focused on within the first two years as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities.
Learning objectiveFirst identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences, which are focused on within the first two years as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities.
ContentIntroduction to Pharmaceutical Sciences by selected milestones of research and development. Overview on research activities at the Institute of Pharmaceutical Sciences, which is focused on drug delivery and development (from concepts to prototypes). Sensitization for communication skills and information management. Demonstration of job opportunities in community pharmacies, in the hospital, in industry, and in the public sector by experts in the different fields.
Lecture notesHandouts for individual lectures.
Prerequisites / NoticeInteractive teaching
535-0240-00LLaboratory Course in Biopharmacy Restricted registration - show details 2 credits4PS.‑D. Krämer
AbstractExperimental determination of pharmacokinetic parameters in vitro: biotransformation experiments (phase I and II) with rat liver microsomes; determination of partition coefficients in the octanol/buffer system including stability testing; protein binding and displacement studies with bovine serum albumin as binding partner.
Learning objectiveConsolidation and implementation of the lecture "Biopharmazie" (535-0241-00 V).
ContentExperimental determination of pharmacokinetic parameters in vitro: biotransformation experiments (phase I and II) with pork liver microsomes; determination of partition coefficients in the octanol/buffer system including stability testing; protein binding and displacement studies with bovine serum albumin as binding partner.
Lecture notesBiopharmazie Praktikumsskript (Krämer/Wunderli-Allenspach)
LiteratureP. Langguth, G. Fricker, H. Wunderli-Allenspach "Biopharmazie", Wiley-VCH Verlag, Weinheim, 2004
Prerequisites / NoticeRequirements:
Laboratory course in Pharmaceutical Analytics passed
Lecture in Biopharmacy in the same semester or previously
535-0241-03LBiopharmacy3 credits3VS.‑D. Krämer
AbstractIntroduction to the Basics in Biopharmacy. Pharmacokinetic processes (absorption, distribution, metabolism and excretion, ADME), which determine the fate of a drug in the body. Knowledge of the most important pharmacokinetic parameters. Interpretation of concentration-time-profiles of drugs. Pharmacokinetic profiling of drugs in view of therapy optimization and analysis of interaction potential.
Learning objectiveIntroduction to the Basics in Biopharmacy. Pharmacokinetic processes (absorption, distribution, metabolism and excretion, ADME), which determine the fate of a drug in the body. Knowledge of the most important pharmacokinetic parameters. Interpretation of concentration-time-profiles of drugs. Pharmacokinetic profiling of drugs in view of therapy optimization and analysis of interaction potential.
ContentIntroduction to pharmacokinetics; definition of the most important pharmacokinetic parameters and their calculation from clinical data (compartment model, statistical model); kinetics of absorption (absorption profiles); distribution of drugs and role of protein binding; kinetics of elimination: excretion and biotransformation (physiological model); pharmacokinetic profiling of drugs for therapy optimization and for the analysis of the interaction potential; dosage regimen design.
LiteratureP. Langguth, G. Fricker, H. Wunderli-Allenspach "Biopharmazie", Wiley-VCH Verlag, Weinheim, 2004.