Name | Prof. Stefanie-Dorothea Krämer |
Field | Biopharmacy |
Address | Inst. f. Pharmazeutische Wiss. ETH Zürich, HCI H 409 Vladimir-Prelog-Weg 1-5/10 8093 Zürich SWITZERLAND |
Telephone | +41 44 633 74 03 |
Fax | +41 44 633 14 57 |
stefanie.kraemer@pharma.ethz.ch | |
URL | http://www.biopharmacy.ethz.ch/ |
Department | Chemistry and Applied Biosciences |
Relationship | Adjunct Professor and Privatdozentin |
Number | Title | ECTS | Hours | Lecturers | |
---|---|---|---|---|---|
535-0002-00L | Introduction to Pharmaceutical Sciences II | 3 credits | 2V | J. Hall, K.‑H. Altmann, S. M. Ametamey, S.‑D. Krämer, J.‑C. Leroux, D. Neri, U. Quitterer, R. Schibli, C. Steuer | |
Abstract | First identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences, which are focused on within the first two years as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities. | ||||
Learning objective | First identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences, which are focused on within the first two years as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities. | ||||
Content | Introduction to Pharmaceutical Sciences by selected milestones of research and development. Overview on research activities at the Institute of Pharmaceutical Sciences, which is focused on drug delivery and development (from concepts to prototypes). Sensitization for communication skills and information management. Demonstration of job opportunities in community pharmacies, in the hospital, in industry, and in the public sector by experts in the different fields. | ||||
Lecture notes | Handouts for individual lectures. | ||||
Prerequisites / Notice | Interactive teaching | ||||
535-0240-00L | Laboratory Course in Biopharmacy | 2 credits | 4P | S.‑D. Krämer | |
Abstract | Experimental determination of pharmacokinetic parameters in vitro: biotransformation experiments (phase I and II) with rat liver microsomes; determination of partition coefficients in the octanol/buffer system including stability testing; protein binding and displacement studies with bovine serum albumin as binding partner. | ||||
Learning objective | Consolidation and implementation of the lecture "Biopharmazie" (535-0241-00 V). | ||||
Content | Experimental determination of pharmacokinetic parameters in vitro: biotransformation experiments (phase I and II) with pork liver microsomes; determination of partition coefficients in the octanol/buffer system including stability testing; protein binding and displacement studies with bovine serum albumin as binding partner. | ||||
Lecture notes | Biopharmazie Praktikumsskript (Krämer/Wunderli-Allenspach) | ||||
Literature | P. Langguth, G. Fricker, H. Wunderli-Allenspach "Biopharmazie", Wiley-VCH Verlag, Weinheim, 2004 | ||||
Prerequisites / Notice | Requirements: Laboratory course in Pharmaceutical Analytics passed Lecture in Biopharmacy in the same semester or previously | ||||
535-0241-03L | Biopharmacy | 3 credits | 3V | S.‑D. Krämer | |
Abstract | Introduction to the Basics in Biopharmacy. Pharmacokinetic processes (absorption, distribution, metabolism and excretion, ADME), which determine the fate of a drug in the body. Knowledge of the most important pharmacokinetic parameters. Interpretation of concentration-time-profiles of drugs. Pharmacokinetic profiling of drugs in view of therapy optimization and analysis of interaction potential. | ||||
Learning objective | Introduction to the Basics in Biopharmacy. Pharmacokinetic processes (absorption, distribution, metabolism and excretion, ADME), which determine the fate of a drug in the body. Knowledge of the most important pharmacokinetic parameters. Interpretation of concentration-time-profiles of drugs. Pharmacokinetic profiling of drugs in view of therapy optimization and analysis of interaction potential. | ||||
Content | Introduction to pharmacokinetics; definition of the most important pharmacokinetic parameters and their calculation from clinical data (compartment model, statistical model); kinetics of absorption (absorption profiles); distribution of drugs and role of protein binding; kinetics of elimination: excretion and biotransformation (physiological model); pharmacokinetic profiling of drugs for therapy optimization and for the analysis of the interaction potential; dosage regimen design. | ||||
Literature | P. Langguth, G. Fricker, H. Wunderli-Allenspach "Biopharmazie", Wiley-VCH Verlag, Weinheim, 2004. |