Karl-Heinz Altmann: Catalogue data in Spring Semester 2021 |
| Name | Prof. em. Dr. Karl-Heinz Altmann |
| Field | Pharmazeutische Biologie |
| Address | Inst. f. Pharmazeutische Wiss. ETH Zürich, HCI H 405 Vladimir-Prelog-Weg 1-5/10 8093 Zürich SWITZERLAND |
| karl-heinz.altmann@pharma.ethz.ch | |
| Department | Chemistry and Applied Biosciences |
| Relationship | Professor emeritus |
| Number | Title | ECTS | Hours | Lecturers | |
|---|---|---|---|---|---|
| 535-0349-00L | Laboratory Course Pharmaceutical Biology  | 3 credits | 6P | K.‑H. Altmann, B. Falch, B. Pfeiffer | |
| Abstract | Microscopic analysis of plant material (pharmacopoeia). Chromatographic analysis of medicinal plants, extraction methods, qualitative/quantitative determination of medicinal plant constituents, isolation of natural products, identification/purity determination of herbal drugs and natural products by means of spectroscopic, chemical, and chromatographic methods. | ||||
| Learning objective | Ability to perform phytochemical work at the practical level, knowledge and understanding of the qualitative and quantitative methods available for the analytical characterization of medicinal plants and plant extracts. Understanding the physical, chemical, and chromatographic behaviour of different classes of natural products, such as, e. g., flavonoids. alkaloids, essential oils etc. | ||||
| Content | Microscopic analysis of plant material (in particular with reference to pharmacopoeia specifications). Chromatographic analysis of medicinal plants, different extraction methods, qualitative and quantitative determination of medicinal plant constituents, isolation of natural products, identification and purity determination of herbal drugs and natural products by means of physical, spectroscopic, chemical, and chromatographic methods. | ||||
| Lecture notes | Will be provided at the beginning of the course. | ||||
| Literature | O. Sticher, J. Heilmann, I. Zündorf: Hänsel/Sticher Pharmakognosie Phytopharmazie, 10. Auflage 2014, Wissenschaftliche Verlagsgesellschaft, Stuttgart. Auch möglich: 9. Auflage 2009 (R. Hänsel, O. Sticher: Pharmakognosie Phytopharmazie, Springer Verlag, Berlin) oder 8. Auflage 2007 (R. Hänsel, O. Sticher: Pharmakognosie Phytopharmazie, Springer Verlag, Berlin) - H. Wagner, S. Bladt, Plant Drug Analysis. A Thin Layer Chromatography Atlas, Springer, 1996. - K.P. Adam, H. Becker, Analytik biogener Arzneistoffe, Wiss. Verlagsges. mbH Stuttgart, 2000. - W. Eschrich, Pulver-Atlas der Drogen, 9. Auflage, Deutscher Apotheker Verlag, Stuttgart, 2009. | ||||
| Prerequisites / Notice | Requirements: Laboratory course in Pharmaceutical Analytics passed Lecture in Biopharmacy in the same semester or previously Safety concept: https://chab.ethz.ch/studium/bachelor1.html | ||||
| 535-0900-00L | Seminars on Drug Discovery and Development | 1 credit | 1K | R. Schibli, K.‑H. Altmann, M. Detmar, C. Halin Winter, J. Hall, J.‑C. Leroux, U. Quitterer, G. Schneider, H. U. Zeilhofer | |
| Abstract | State-of-the-art information on drug discovery and development by experts from academia and industry. | ||||
| Learning objective | State-of-the-art information on drug discovery and development. | ||||
| Content | Seminar series of the Institute of Pharmaceutical Sciences. Experts from academia and industry report on relevant topics. | ||||
| 535-0901-00L | From A to Z in Drug Discovery and Development Does not take place this semester. | 2 credits | 2S | J. Hall, K.‑H. Altmann, M. Detmar, R. Schibli, H. U. Zeilhofer | |
| Abstract | The lecture series takes place at the ETH Hönggerberg and covers a variety of major activities involved in drug discovery: selecting drug targets, technologies used in drug discovery, small, medium and large drugs, objectives of the medicinal chemist, assessing drug safety, principles of personalized medicine, designing clinical trials, how intellectual property is protected, as well as others. | ||||
| Learning objective | The objective of the course is to gain a global understanding of most of the important phases in the discovery and development of modern synthetic and biological drugs, from the first activities to clinical trials. The lecture is intended for students that have an interest in the area and/or may consider a career working in drug discovery. This lecture course complements knowledge and experience gained in the research project performed by the PhD student. | ||||
| Content | Fifteen two hour lectures for life-science PhD students, given by experts from the ETH, UZH, USZ and the pharmaceutical industry. Introduction to the modern drug discovery process - Principles of drug pharmacokinetics and drug metabolism - Computer sciences in drug discovery - Drug targets - In vitro methods in drug discovery - Natural products in drug discovery - Medicinal chemistry: Chemical lead selection/optimization - Nucleic acid-based drugs - Antibodies and therapeutic proteins: Targets and drugs - In vivo molecular imaging in drug discovery - Personalized medicine in drug discovery and development - Drug formulation: Key development consideration, Current new APIs challenges and FDA rising standards - Preclinical safety, adverse drug events and drug-drug interactions - Clinical development steps including trial design - Intellectual property in drug discovery and development | ||||
| Lecture notes | Scripts to be uploaded into ILIAS | ||||
| Literature | To be distributed during the lecture | ||||
| Prerequisites / Notice | Formally none, but a basic understanding in biochemistry, physiology and chemistry is highly desirable as it will certainly help to get the most from the lectures. | ||||