Ralph Müller: Catalogue data in Autumn Semester 2017

Name Prof. Dr. Ralph Müller
FieldBiomechanik
Address
Institut für Biomechanik
ETH Zürich, GLC H 15.1
Gloriastrasse 37/ 39
8092 Zürich
SWITZERLAND
Telephone+41 44 632 45 92
Fax+41 44 633 11 24
E-mailram@ethz.ch
URLhttp://n.ethz.ch/~ram/cv.html
DepartmentHealth Sciences and Technology
RelationshipFull Professor

NumberTitleECTSHoursLecturers
376-0021-00LIntroduction to Biomedical Engineering I4 credits3GR. Müller, J. G. Snedeker, M. Zenobi-Wong
AbstractIntroduction to biomechanics, biomaterials, tissue engineering, medical imaging as well as the history of biomedical engineering.
ObjectiveUnderstanding of physical and technical principles in biomechanics, biomaterials, tissue engineering, medical imaging as well as the history of biomedical engineering. Mathematical description and problem solving. Knowledge of biomedical engineering applications in research and clinical practice.
ContentTissue and Cellular Biomechanics, Molecular Biomechanics and Biopolymers, Computational Biomechanics, Biomaterials, Tissue Engineering, Radiation and Radiographic Imaging, Diagnostic Ultrasound Imaging, Magnetic Resonance Imaging,
Biomedical Optics and Lasers.
Lecture notesStored on ILIAS.
LiteratureIntroduction to Biomedical Engineering, 3rd Edition 2011,
Autor: John Enderle, Joseph Bronzino, ISBN 9780123749796
Academic Press
376-0121-00LMultiscale Bone Biomechanics Restricted registration - show details
Number of participants limited to 25.
6 credits4SR. Müller
AbstractThe seminar provides state-of-the-art insight to the biomechanical function of bone from molecules, to cells, tissue and up to the organ. Multiscale imaging and simulation allows linking different levels of hierarchy, where systems biology helps understanding the mechanobiological response of bone to loading and injury in scenarios relevant for personalized health and translational medicine.
ObjectiveThe learning objectives include 1. advanced knowledge of the state-of-the-are in multiscale bone biomechanics; 2. basic understanding of the biological principles governing bone in health, disease and treatment from molecules, to cells, tissue and up to the organ; 3. good understanding of the prevalent biomechanical testing and imaging techniques on the various levels of bone hierarchy; 4. practical implementation of state-of-the-art multiscale simulation techniques; 5. improved programing skills through the use of 4th generation scripting language; 6. hands on experience in designing solutions for clinical and industrial problems; 7. encouragement of critical thinking and creating an environment for independent and self-directed studying.
ContentBone is one of the most investigated biological materials due to its primary function of providing skeletal stability. Bone is susceptible to different local stimuli including mechanical forces and has great capabilities in adapting its mechanical properties to the changes in its environment. Nevertheless, aging or hormonal changes can make bone lose its ability to remodel appropriately, with loss of strength and increased fracture risk as a result, leading to devastating diseases such as osteoporosis. To better understand the biomechanical function of bone, one has to understand the hierarchical organization of this fascinating material down from the molecules, to the cells, tissue and up to the organ. Multiscale imaging and simulation allows to link these different levels of hierarchy. Incorporating systems biology approaches, not only biomechanical strength of the material can be assessed but also the mechanobiological response of the bone triggered by loading and injury in scenarios relevant for personalized health and translational medicine. Watching cells working together to build and repair bone in a coordinated fashion is a spectacle, which will need dynamic image content and deep discussions in the lecture room to probe the imagination of the individual student interested in the topic.

For the seminar, concepts of video lectures will be used in a flipped class room setup, where students can study the basic biology, engineering and mathematical concepts in video tutorials online. All videos and animations will be incorporated in an eSkript (eskript.ethz.ch) allowing studying and eventually even interactive course participation online. It is anticipated that the students need to prepare 2x45 minutes for the study of the actual lecture material. The Friday morning time slots will be used for students, who want to complete these assignments in a classroom setting. The student will have to study independently or in groups, but lecturer will be available for questions and answers during that time. In the Friday afternoon time slots, short clips with video/animation content will be used to introduce problems and discuss specific scientific findings using multiscale imaging and simulation technology. The students will have to form small groups to try to solve such problems and to present their solutions for advanced multiscale investigation of bone ranging from basic science to personalized health and onto translational medicine.
Lecture notesMaterial will be provided in Moodle and eScript (eskript.ethz.ch).
Prerequisites / NoticeSeminar will be held in English.
376-1974-00LColloquium in Biomechanics Information 2 credits2KB. Helgason, S. J. Ferguson, R. Müller, J. G. Snedeker, W. R. Taylor, K. Würtz-Kozak, M. Zenobi-Wong
AbstractCurrent topics in biomechanics presented by speakers from academia and industry.
ObjectiveGetting insight into actual areas and problems of biomechanics.