Jörn Piel: Katalogdaten im Herbstsemester 2023 |
Name | Herr Prof. Dr. Jörn Piel |
Lehrgebiet | Mikrobielle Interaktionen |
Adresse | Institut für Mikrobiologie ETH Zürich, HCI G 431 Vladimir-Prelog-Weg 1-5/10 8093 Zürich SWITZERLAND |
Telefon | +41 44 633 07 55 |
jpiel@micro.biol.ethz.ch | |
Departement | Biologie |
Beziehung | Ordentlicher Professor |
Nummer | Titel | ECTS | Umfang | Dozierende | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
551-0125-00L | Grundlagen der Biologie I: von Molekülen zur Biochemie der Zellen | 6 KP | 5G | J. Vorholt-Zambelli, N. Ban, R. Glockshuber, K. Locher, J. Piel | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Kurzbeschreibung | Die Vorlesung vermittelt eine Einführung in die Grundlagen der Biochemie und Molekularbiologie sowie evolutionäre Prinzipien. Der Schwerpunkt liegt auf Bacteria und Archaea unter Berücksichtigung universeller Konzepte. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Lernziel | Einführung in die Biochemie und Molekularbiologie sowie evolutionäre Zusammenhänge | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inhalt | Die Lehrveranstaltung führt in die Biologie als interdisziplinäre Wissenschaft ein. Verbindungen zur Physik und Chemie werden aufgezeigt, da biologische Prozesse innerhalb der Gesetze der Thermodynamik ablaufen und auf Elementen, Molekülen und chemischen Reaktionen basieren. Der Übergang von der Geo- zur Biochemie wird diskutiert und im Zusammenhang mit dem Ursprung des Lebens betrachtet. Evolutionäre Prinzipien werden eingeführt und daraus resultierende Prozesse als Leitfaden verwendet. Es werden vereinheitlichende Konzepte in der Biologie vorgestellt, einschliesslich des Aufbaus und der Funktion zellulärer Makromoleküle und der Art der Kodierung, Dekodierung und Vervielfältigung vererbbarer Information. Zentrale Grundlagen der universellen Energieumwandlung werden ausgehend von Redoxprozessen und mit Schwerpunkt auf Bakterien und Archaeen betrachtet. Schliesslich werden biologische Prozesse in eine ökosystemorientierte Perspektive gestellt. Der Vorlesung ist in verschiedene Abschnitte gegliedert: 1. Geochemische Perspektiven der Erde und Einführung in die Evolution 2. Bausteine des Lebens 3. Makromoleküle: Proteine 4. Membranen und Transport durch die Plasmamembran 5. Universelle Mechanismen der Replikation, Transkription und Translation 6. Reaktionskinetik, Bindungsgleichgewichte und enzymatische Katalyse 7. Energiestoffwechsel 8. Baustoffwechsel 9. Metabolismus und biogeochemische Kreislauf der Elemente | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Skript | Die neu konzipierte Vorlesung wird durch Skripte unterstützt. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Literatur | Die Vorlesung wird durch Skripte unterstützt. Die Vorlesung enthält Elemente aus den Lehrbüchern "Brock Biology of Microorganisms", Madigan et al. 15th edition, Pearson und "Biochemistry" (Stryer), Berg et al. 9th edition, Macmillan international. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Kompetenzen![]() |
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
551-0313-00L | Microbiology (Part I) | 3 KP | 2V | W.‑D. Hardt, L. Eberl, B. Nguyen, J. Piel, M. Pilhofer, A. Vagstad | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Kurzbeschreibung | Advanced lecture class providing a broad overview on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Lernziel | This concept class will be based on common concepts and introduce to the enormous diversity among bacteria and archaea. It will cover the current research on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inhalt | Advanced class covering the state of the research in bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Skript | Updated handouts will be provided during the class. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Literatur | Current literature references will be provided during the lectures. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Voraussetzungen / Besonderes | English The lecture "Grundlagen der Biologie II: Mikrobiologie" is the basis for this advanced lecture. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
551-1106-00L | Progress Reports in Microbiology and Immunology Students must sign up via secr.micro.biol.ethz.ch | 0 KP | 5S | J. Piel, W.‑D. Hardt, A. Oxenius, J. Vorholt-Zambelli | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Kurzbeschreibung | Presentation and discussion of current research results in the field of Microbiology and Infection Immunology | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Lernziel | Precise and transparent presentation of research findings in relation to the current literature, critical discussion of experimental data and their interpretation, development and presentation of future research aims | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
551-1109-00L | Seminars in Microbiology | 0 KP | 2K | S. Sunagawa, W.‑D. Hardt, M. Künzler, J. Piel, J. Vorholt-Zambelli | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Kurzbeschreibung | Seminars by invited speakers covering selected microbiology themes. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Lernziel | Discussion of selected microbiology themes presented by invited speakers. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
551-1147-00L | Bioactive Natural Products from Bacteria ![]() Number of participants limited to 8. The enrolment is done by the D-BIOL study administration. | 6 KP | 7P | J. Piel | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Kurzbeschreibung | Lab course. In small groups projects of relevance to current research questions in the field of bacterial natural product biosynthesis are addressed. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Lernziel | Introduction to relevant subjects of the secondary metabolism of bacteria. Training in practical work in a research laboratory. Scientific writing in form of a research report. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inhalt | Research project on bacteria that produce bioactive natural products (e.g., Streptomycetes, Cyanobacteria, uncultivated bacteria). The techniques used will depend on the project, e.g. PCR, cloning, natural product analysis, precursor feeding studies, enzyme expression and analysis. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Skript | none. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Literatur | Will be provided for each of the projects at the beginning of the course. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
551-1149-00L | Pharmaceutical Discovery from Microbial Communities ![]() ![]() Number of participants limited to 3. The enrolment is done by the D-BIOL study administration. | 6 KP | 7P | A. E. Fraley, J. Piel | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Kurzbeschreibung | In this block course, students explore the metabolic potential of microbial communities from unique environments located in the UNESCO Biosphere Reserve Entlebuch. We will identify microorganisms cohabitating with extremophile mosses, and discover bioactive metabolites produced within these ecological niches. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Lernziel | Natural products have long been used as medicine. In this block course, students explore the metabolic potential of microbial communities from peat bogs located in the UNESCO Biosphere Reserve Entlebuch. Peat moss is an incredibly important source of carbon storage, sequestering more CO2 than all of the rainforests. Degradation of these mosses would cause a massive release of greenhouse gases. For this reason, the peatlands in the Entlebuch are one of the most protected natural resources in Switzerland. We are interested in studying the microbial populations of these mosses in order to understand the contributions of secondary metabolites toward peat moss sustainability. In this course, you will learn taxonomic identification of biologically relevant microbes and mosses as well as proper field collection techniques. Lab work will include the extraction and purification of natural products in the lab, followed by assays for therapeutic properties. From discovery by organic extraction, fractionation, and column chromatography, to analysis via HPLC and mass spectrometry, you will learn first-hand how a natural compound becomes a therapeutic drug. The students will receive an introduction to relevant subjects of the secondary metabolism of bacteria and plants. Lectures will include an introduction to natural products and drug discovery, bioprospecting and industrial fermentation, relevant analytical methods, microbial communities and metagenomics. The students will receive training in practical work in a research laboratory as well as scientific literacy skills in the form of a research report and oral presentation. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inhalt | The students will work on a research project focusing on the discovery of bioactive natural products from environmental samples which they will collect in the UNESCO Biosphere Reserve Entlebuch. Students will learn from lectures in class, lab and in the field and gain experience with field collection techniques and the sequence of steps required for natural products discovery including organic extraction, fractionation, and column chromatography. They will use analytical techniques such as HPLC and mass spectrometry for initial characterization of the purified secondary metabolites. Primary biological assays will be conducted to identify natural product extracts and fractions with antibiotic activity as a first step in the drug discovery process. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Skript | Provided after each lecture. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Literatur | Additional materials will be provided before the start of the course. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Voraussetzungen / Besonderes | None | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Kompetenzen![]() |
|