Katharina Maniura: Katalogdaten im Frühjahrssemester 2020

Name	Frau Prof. Dr. Katharina Maniura
Adresse	EMPA St.Gallen Lerchenfeldstrasse 5 9014 St. Gallen SWITZERLAND
Telefon	071 274 7447
E-Mail	katharina.maniura@hest.ethz.ch
Departement	Gesundheitswissenschaften und Technologie
Beziehung	Titularprofessorin

Nummer	Titel	ECTS	Umfang	Dozierende
376-1614-00L	Principles in Tissue Engineering	3 KP	2V	K. Maniura, M. Rottmar, M. Zenobi-Wong
Kurzbeschreibung	Fundamentals in blood coagulation; thrombosis, blood rheology, immune system, inflammation, foreign body reaction on the molecular level and the entire body are discussed. Applications of biomaterials for tissue engineering in different tissues are introduced. Fundamentals in medical implantology, in situ drug release, cell transplantation and stem cell biology are discussed.
Lernziel	Understanding of molecular aspects for the application of biodegradable and biocompatible Materials. Fundamentals of tissue reactions (eg. immune responses) against implants and possible clinical consequences will be discussed.
Inhalt	This class continues with applications of biomaterials and devices introduced in Biocompatible Materials I. Fundamentals in blood coagulation; thrombosis, blood rheology; immune system, inflammation, foreign body reaction on the level of the entire body and on the molecular level are introduced. Applications of biomaterials for tissue engineering in the vascular system, skeletal muscle, heart muscle, tendons and ligaments, bone, teeth, nerve and brain, and drug delivery systems are introduced. Fundamentals in medical implantology, in situ drug release, cell transplantation and stem cell biology are discussed.
Skript	Handouts provided during the classes and references therin.
Literatur	The molecular Biology of the Cell, Alberts et al., 5th Edition, 2009. Principles in Tissue Engineering, Langer et al., 2nd Edition, 2002
376-1714-AAL	Biocompatible Materials Belegung ist NUR erlaubt für MSc Studierende, die diese Lerneinheit als Auflagenfach verfügt haben. Alle anderen Studierenden (u.a. auch Mobilitätsstudierende, Doktorierende) können diese Lerneinheit NICHT belegen.	4 KP	9R	K. Maniura, M. Zenobi-Wong
Kurzbeschreibung	Introduction to molecules used for biomaterials, molecular interactions between different materials and biological systems (molecules, cells, tissues). The concept of biocompatibility is discussed and important techniques from biomaterials research and development are introduced.
Lernziel	The course covers the follwing topics: 1. Introdcution into molecular characteristics of molecules involved in the materials-to-biology interface. Molecular design of biomaterials. 2. The concept of biocompatibility. 3. Introduction into methodology used in biomaterials research and application. 4. Introduction to different material classes in use for medical applications.
Inhalt	Introduction into natural and polymeric biomaterials used for medical applications. The concepts of biocompatibility, biodegradation and the consequences of degradation products are discussed on the molecular level. Different classes of materials with respect to potential applications in tissue engineering, drug delivery and for medical devices are introduced. Strong focus lies on the molecular interactions between materials having very different bulk and/or surface chemistry with living cells, tissues and organs. In particular the interface between the materials surfaces and the eukaryotic cell surface and possible reactions of the cells with an implant material are elucidated. Techniques to design, produce and characterize materials in vitro as well as in vivo analysis of implanted and explanted materials are discussed. A link between academic research and industrial entrepreneurship is demonstrated by external guest speakers, who present their current research topics.
Skript	Handouts are deposited online (moodle).
Literatur	Literature: - Biomaterials Science: An Introduction to Materials in Medicine, Ratner B.D. et al, 3rd Edition, 2013 - Comprehensive Biomaterials, Ducheyne P. et al., 1st Edition, 2011 (available online via ETH library) Handouts and references therin.