Marcy Zenobi-Wong: Katalogdaten im Frühjahrssemester 2013

NameFrau Prof. Dr. Marcy Zenobi-Wong
LehrgebietKnorpeltechnologie und -regeneration
Gewebetechnol. und Biofabrikation
ETH Zürich, HPL J 22
Otto-Stern-Weg 7
8093 Zürich
Telefon+41 44 632 50 89
DepartementGesundheitswissenschaften und Technologie
BeziehungOrdentliche Professorin

376-0016-00LPraktikum Gesundheitstechnologie Belegung eingeschränkt - Details anzeigen
Findet dieses Semester nicht statt.
2 KP2PS. Lorenzetti, S. J. Ferguson, R. Gassert, R. Müller, R. Riener, J. G. Snedeker, V. Vogel, M. Zenobi-Wong
KurzbeschreibungPraktischer Laborkurs mit grundlegenden Experimenten.
LernzielGrundlegende Experimente zum Erlernen von Messmethoden und praktischen Anwendungen in der Gesundheitstechnologie durchführen und auswerten.
InhaltZugversuch Sehne / Knochenbrecher / Bewegungsmessung Mensch / Zellkultur / Materialtestung / Mensch-Maschine - Interaktion
Skriptsind auf moodle Plattform verfügbar.
376-1392-00LMechanobiology: Implications for Development, Regeneration and Tissue Engineering2 KP2GA. Ferrari, A. Franco-Obregon, M. Zenobi-Wong
KurzbeschreibungThis course will emphasize the importance of mechanobiology to cell determination and behavior. Its importance to regenerative medicine and tissue engineering will also be addressed. Finally, this course will discuss how age and disease adversely alter major mechanosensitive developmental programs.
LernzielThis course is designed to illuminate the importance of mechanobiological processes to life as well as to teach good experimental strategies to investigate mechanobiological phenomena.
InhaltTypically, cell differentiation is studied under static conditions (cells grown on rigid plastic tissue culture dishes in two-dimensions), an experimental approach that, while simplifying the requirements considerably, is short-sighted in scope. It is becoming increasingly apparent that many tissues modulate their developmental programs to specifically match the mechanical stresses that they will encounter in later life. Examples of known mechanosensitive developmental programs include all forms of myogenesis (cardiac, skeletal and smooth muscles), osteogenesis (bones), chondrogenesis (cartilage), tendogenesis (tendons) and angiogenesis (blood vessels). Furthermore, general forms of cell behavior such as migration, extracellular matrix deposition, and complex tissue differentiation are also regulated by mechanical stimuli. Mechanically-regulated cellular processes are thus ubiquitous, ongoing and of great clinical importance.

The overall importance of mechanobiology to humankind is illustrated by the fact that nearly 80% of our entire body mass arises from tissues originating from mechanosensitive developmental programs, principally bones and muscles. Unfortunately, our ability to regenerate mechanosensitive tissue diminishes in later life. As it is estimated that the fraction of the western world population over 65 years of age will double in the next 25 years, an urgency in the global biomedical arena exists to better understand how to optimize complex tissue development under physiologically-relevant mechanical environments for purposes of regenerative medicine and tissue engineering.
LiteraturTopical Scientific Manuscripts
376-1614-00LBiocompatible Materials II: Principles in Tissue Engineering2 KP2VK. Maniura, A.‑K. Born, P. M. Kollmannsberger, M. Zenobi-Wong
KurzbeschreibungFundamentals in blood coagulation; thrombosis, blood rheology, immune system, inflammation, foreign body reaction on the molecular level and the entire body are discussed. Applications of biomaterials for tissue engineering in different tissues are introduced. Fundamentals in medical implantology, in situ drug release, cell transplantation and stem cell biology are discussed.
LernzielUnderstanding of molecular aspects for the application of biodegradable and biocompatible Materials. Fundamentals of tissue reactions (eg. immune responses) against implants and possible clinical consequences will be discussed.
InhaltThis class continues with applications of biomaterials and devices introduced in Biocompatible Materials I. Fundamentals in blood coagulation; thrombosis, blood rheology; immune system, inflammation, foreign body reaction on the level of the entire body and on the molecular level are introduced. Applications of biomaterials for tissue engineering in the vascular system, skeletal muscle, heart muscle, tendons and ligaments, bone, teeth, nerve and brain, and drug delivery systems are introduced. Fundamentals in medical implantology, in situ drug release, cell transplantation and stem cell biology are discussed.
SkriptHandouts provided during the classes and references therin.
LiteraturThe molecular Biology of the Cell, Alberts et al., 5th Edition, 2009.
Principles in Tissue Engineering, Langer et al., 2nd Edition, 2002
Voraussetzungen / BesonderesThe participant receives 2 KP and a grade after fulfilling the following criteria:

- 1x written homework
- 1x endterm examination.