Linjing Mu: Catalogue data in Autumn Semester 2021 |
| Name | Dr. Linjing Mu |
| Address | Radiopharmacy ETH Zürich, HCI H 427 Vladimir-Prelog-Weg 1-5/10 8093 Zürich SWITZERLAND |
| Telephone | +41 44 633 61 96 |
| linjing.mu@pharma.ethz.ch | |
| Department | Chemistry and Applied Biosciences |
| Relationship | Lecturer |
| Number | Title | ECTS | Hours | Lecturers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 535-0210-00L | Radiopharmaceutical Chemistry | 2 credits | 2V | R. Schibli, L. Mu | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | -Molecular imaging in drug development -Radiopharmaceutical syntheses -Knowledge of the physical principles of radioactivity -Structure and function of radiopharmaceuticals -Examples of application in diagnosis and therapy in humans -Targeted radionuclide therapy | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | - The students know and are able to describe the different imaging procedures in medicine, especially PET and SPET. - At the end of the lecture, the students are able to explain and describe the physical basics in connection with radioactivity and the different types of radioactive radiation that are relevant in radiopharmacy and nuclear medicine. - The students know how radionuclides can be produced and extracted. - The students can describe the structure and function of radiopharmaceuticals and are able to develop strategies for the design of new radiopharmaceuticals. - The students know selected examples of clinically relevant radiopharmaceuticals and can explain the structure and mechanism of action. - The students can discuss and apply the principles of internal dosimetry of systemically applied radiopharmaceuticals using selected examples. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Introduction to molecular imaging, Radioactive decay, radiation and radionuclides relevant in nuclear medicine. Radionuclide generators Radiopharmaceutical synthesis strategies Heart, brain and tumour diagnostics with radiopharmaceuticals Kinetic modelling with radiopharmaceuticals Tumour therapy with radiopharmaceuticals Dosimetry of radiopharmaceuticals Practical aspect of nuclear medicine and radiopharmacy | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Book Title: Fundamentals of Nuclear Pharmacy Authors Gopal B. Saha DOI https://doi.org/10.1007/978-3-319-57580-3. Book Title: Radiopharmaceuticals Book Subtitle A Guide to PET/CT and PET/MRI Editors Ferdinando Calabria, Orazio Schillaci DOI https://doi.org/10.1007/978-3-030-27779-6. Book Title Radiopharmaceutical Chemistry Editors Jason S. Lewis Albert D. Windhorst, Brian M. Zeglis DOI https://doi.org/10.1007/978-3-319-98947-1. Access via ETH Library | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Prerequisites: basic knowledge in physics and chemsitry | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Competencies |
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