G.V. Shivashankar: Katalogdaten im Frühjahrssemester 2021

NameHerr Prof. Dr. G.V. Shivashankar
Paul Scherrer Institute
Forschungsstrasse 111
OFLC 107
5232 Villigen PSI
DepartementGesundheitswissenschaften und Technologie
BeziehungOrdentlicher Professor

376-0304-00LColloquium in Translational Science (Spring Semester)1 KP1KN. Cesarovic, A. Alimonti, C. Ewald, V. Falk, J. Goldhahn, K. Maniura, M. Ristow, R. M. Rossi, S. Schürle-Finke, G. Shivashankar, E. Vayena, V. Vogel, F. von Meyenn
KurzbeschreibungCurrent topics in translational medicine presented by speakers from academia and industry.
LernzielGetting insight into actual areas and problems of translational medicine.
InhaltTimely and concise presentations of postgraduate students, post-docs, senior scientists, professors, as well as external guests from both academics and industry will present topics of their interest related to translational medicine.
Voraussetzungen / BesonderesNo compulsory prerequisites, but student should have basic knowledge about biomedical research.
376-1392-00LMechanobiology: Implications for Development, Regeneration and Tissue Engineering3 KP2GG. Shivashankar
KurzbeschreibungThis course will emphasize the importance of mechanobiology to cell determination and behavior. Its importance to regenerative medicine and tissue engineering will also be addressed. Finally, this course will discuss how age and disease adversely alter major mechanosensitive developmental programs.
LernzielThe goal of this course is to provide an introduction to the emerging field of “Mechanobiology”.
InhaltWe will focus on cells and tissues and introduce the major methods employed in uncovering the principles of mechanobiology. We will first discuss the cellular mechanotransduction mechanisms and how they regulate genomes. This will be followed by an analysis of the mechanobiological underpinnings of cellular differentiation, cell-state transitions and homeostasis. Developing on this understanding, we will then introduce the mechanobiological basis of cellular ageing and its impact on tissue regeneration, including neurodegeneration and musculoskeletal systems. We will then highlight the importance of tissue organoid models as routes to regenerative medicine. We will also discuss the impact of mechanobiology on host-pathogen interactions. Finally, we will introduce the broad area of mechanopathology and the development of cell-state biomarkers as readouts of tissue homeostasis and disease pathologies. Collectively, the course will provide a quantitate framework to understand the mechanobiological processes at cellular scale and how they intersect with tissue function and diseases.

Lecture 1: Introduction to the course: forces, signalling and cell behaviour
Lecture 2: Methods to engineer and sense mechanobiological processes
Lecture 3: Mechanisms of cellular mechanosensing and cytoskeletal remodelling
Lecture 4: Nuclear mechanotransduction pathways
Lecture 5: Genome organization, regulation and genome integrity
Lecture 6: Differentiation, development and reprogramming
Lecture 7: Tissue microenvironment, cell behaviour and homeostasis
Lecture 8: Cellular aging and tissue regeneration
Lecture 9: Neurodegeneration and regeneration
Lecture 10: Musculoskeletal systems and regeneration
Lecture 11: Tissue organoid models and regenerative medicine
Lecture 12: Microbial systems and host-pathogen interactions
Lecture13: Mechanopathology and cell-state biomarkers
Lecture14: Concluding lecture and case studies
LiteraturTopical Scientific Manuscripts