G.V. Shivashankar: Catalogue data in Autumn Semester 2022

Name Prof. Dr. G.V. Shivashankar
Paul Scherrer Institute
Forschungsstrasse 111
OFLC 107
5232 Villigen PSI
DepartmentHealth Sciences and Technology
RelationshipFull Professor

376-0303-00LColloquium in Translational Science (Autumn Semester)1 credit1KN. Cesarovic, A. Alimonti, C. Ewald, V. Falk, J. Goldhahn, K. Maniura, M. Ristow, R. M. Rossi, S. Schürle-Finke, G. Shivashankar, E. Vayena, V. Vogel
AbstractCurrent topics in translational medicine presented by speakers from academia and industry.
ObjectiveGetting insight into actual areas and problems of translational medicine.
ContentTimely and concise presentations of postgraduate students, post-docs, senior scientists, professors, as well as external guests from both academics and industry will present topics of their interest related to translational medicine.
Prerequisites / NoticeNo compulsory prerequisites, but student should have basic knowledge about biomedical research.
376-1348-00LCellular Ageing3 credits2VG. Shivashankar
AbstractCells undergo major functional alterations as we age. In this course, we will discuss the basic molecular and cell biological mechanisms of cellular ageing. We will also discuss diseases related to cellular ageing and current rejuvenation and therapeutic strategies for cellular ageing in health and disease.
Objective- Basic molecular and cell biological mechanisms of cellular ageing;
- Diseases related to cellular ageing;
- current rejuvenation and therapeutic strategies for cellular ageing in health and disease.
ContentLecture-1: Hallmarks of cellular ageing
Lecture-2: Cellular microenvironment & extra-cellular matrix
Lecture-3: Cell morphometric changes & cytoskeletal remodeling
Lecture-4: Proteostasis
Lecture-5: Mitochondrial dysfunction
Lecture-6: Endo-membrane signaling
Lecture-7: Nuclear signaling & epigenetic alternations
Lecture-8: Chromatin remodeling & gene expression
Lecture-9: Genomic integrity
Lecture-10: Ageing cell secretome and cellular homeostasis
Lecture-11: Diseases associated with cellular ageing
Lecture-12: Cellular rejuvenation strategies
Lecture-13: Therapeutic interventions to cellular ageing
Lecture-14: Concluding lecture