G.V. Shivashankar: Catalogue data in Spring Semester 2020

Name Prof. Dr. G.V. Shivashankar
FieldMechano-Genomics
Address
Paul Scherrer Institute
Forschungsstrasse 111
OFLC 107
5232 Villigen PSI
SWITZERLAND
E-mailg.v.shivashankar@hest.ethz.ch
DepartmentHealth Sciences and Technology
RelationshipFull Professor

NumberTitleECTSHoursLecturers
376-0304-00LColloquium in Translational Science (Spring Semester)1 credit1KM. Ristow, C. Ewald, V. Falk, J. Goldhahn, J. Mitchell, S. Schürle-Finke, G. Shivashankar, E. Vayena, V. Vogel, F. von Meyenn
AbstractCurrent topics in translational medicine presented by speakers from academia and industry.
ObjectiveGetting insight into actual areas and problems of translational medicine.
ContentTimely and concise presentations of postgraduate students, post-docs, senior scientists, professors, as well as external guests from both academics and industry will present topics of their interest related to translational medicine.
Prerequisites / NoticeNo compulsory prerequisites, but student should have basic knowledge about biomedical research.
376-1392-00LMechanobiology: Implications for Development, Regeneration and Tissue Engineering3 credits2GA. Ferrari, G. Shivashankar, M. Zenobi-Wong
AbstractThis course will emphasize the importance of mechanobiology to cell determination and behavior. Its importance to regenerative medicine and tissue engineering will also be addressed. Finally, this course will discuss how age and disease adversely alter major mechanosensitive developmental programs.
ObjectiveThis course is designed to illuminate the importance of mechanobiological processes to life as well as to teach good experimental strategies to investigate mechanobiological phenomena.
ContentTypically, cell differentiation is studied under static conditions (cells grown on rigid plastic tissue culture dishes in two-dimensions), an experimental approach that, while simplifying the requirements considerably, is short-sighted in scope. It is becoming increasingly apparent that many tissues modulate their developmental programs to specifically match the mechanical stresses that they will encounter in later life. Examples of known mechanosensitive developmental programs include osteogenesis (bones), chondrogenesis (cartilage), and tendogenesis (tendons). Furthermore, general forms of cell behavior such as migration, extracellular matrix deposition, and complex tissue differentiation are also regulated by mechanical stimuli. Mechanically-regulated cellular processes are thus ubiquitous, ongoing and of great clinical importance.

The overall importance of mechanobiology to humankind is illustrated by the fact that nearly 80% of our entire body mass arises from tissues originating from mechanosensitive developmental programs, principally bones and muscles. Unfortunately, our ability to regenerate mechanosensitive tissue diminishes in later life. As it is estimated that the fraction of the western world population over 65 years of age will double in the next 25 years, an urgency in the global biomedical arena exists to better understand how to optimize complex tissue development under physiologically-relevant mechanical environments for purposes of regenerative medicine and tissue engineering.
Lecture notesn/a
LiteratureTopical Scientific Manuscripts