Sabine Goldhahn: Catalogue data in Autumn Semester 2022

Name Dr. Sabine Goldhahn
Professur Translationale Ern.biol.
ETH Zürich, SLA C 5
Schorenstrasse 16
8603 Schwerzenbach
Telephone+41 44 655 72 92
DepartmentHealth Sciences and Technology

377-0513-00LEthics and Legal Aspects and Communication Restricted registration - show details
Only for Human Medicine BSc
4 credits2GS. Goldhahn, T. Krones, B. Tag
AbstractThe students develop the basics of medical law, clinical ethics and communication needed for central applications in the clinic. They learn which relevant legal framework conditions are to be observed in everyday clinical practice and how, in communication with patients, the principles of self-determination, patient well-being and damage avoidance are practically implemented.
ObjectiveAfter passing the modul sucessfully, students should be able to
• Know about ethical and legal basics iof diagnostics and therapy and how these principles are put into practice
• Knowledge and use of central communication skills with patients, health care teams and the public
• Understand and describe the connections of ethics, law and communication and reflect on the implementation in clinical practice
• Apply the concept of evidence based decision aids
• Apply specific communication skills in simple clinical cases (informed consent, shared decision making, breaking bad news, communicaion of medical mistakes, Advance care Planning).
• Understand the concept and needs of vulnerable patients and address the concept ethically, legally and communicate adequately
• Know about the necessity of interprofessional collaboration in the process of dealing with ethically and juridically complex cases and practice first steps.
Content• Overview of clinical ethical cases
• Basics in medical ethics and professional communication
• Knowledge and application of concepts as informed consent, possible alternative juridical instruments
• Knowledge and application of Shared decision Making
• Knowledge and application of advance care planning, concept of advance directices, treatment of patients incapable of decision making
• Breaking bad news, difficult prognoses
• Concept of vulnerability , special needs
• Differences of research/clinic, concept of evidence-based and presonalized medicine
• Conflicts of interests in therapy and research
• Basics on interprofessional cooperation in ethically and legally challenging situations
• Goal of care approach ; delaing with end of life deicisons ,
• Differential diagnoses and misdiagnosis, systems of avoidance of medical mistakes
Prerequisites / NoticeVoraussetzungen:
- LE 377-0405-10L Ethik in Medizin und Gesundheitswesen
- Organsysteme der ersten vier Semester (Prüfungen absolviert)
395-0100-00LFrom Clinical Problem to Research Question Restricted registration - show details
Only for CAS in Modern Concepts in Clinical Research and MAS in digital Clinical Research
1.5 credits2GS. Goldhahn, A. Frotzler, J. Steurer
AbstractThe course will discuss how to design a clinical study and addresses topics such as the quantification of medical need, the reduction of unnecessary complexity, and the identification of clinical outcome measures.
ObjectiveSome of the challenges in administering clinical treatments and disease prevention may look obvious. But their translation into research questions is not trivial. This step is crucial to initiating the necessary research and attracting funding. Therefore, the first module of the CAS ETH in Modern Concepts in Clinical Research (CAS ETH MCCR) will guide participants through designing a clinical study and addresses topics such as the quantification of medical need, the reduction of unnecessary complexity, and the identification of clinical outcome measures.

The course enables participants to…
1. critically analyse clinical trials and scientific literature according to their level of evidence by applying analytical approaches, e.g. PICOT.

2. understand and avoid practical and ethical problems in clinical trials.

3. understand the concept of object design and apply it to clinical research.

4. explain why study participants are randomly selected in RCTs and the implications of this for study conduct and outcomes.

5. explain study outcomes, their hierarchy, and relevance.

6. understand the difference between various clinical outcome assessments (COAs) and their impact on clinical trial outcomes, and explain how patient-reported outcomes are developed, cross-culturally adapted, validated, and used.

7. understand and be able to classify psychometric properties of measurement instruments (reliability, validity, consistency, responsiveness).
395-0101-00LModern Study Concepts Restricted registration - show details
Only for CAS in Modern Concepts in Clinical Research and MAS in digital Clinical Research
1.5 credits1GA. Burden, S. Goldhahn, further lecturers
AbstractIn the course, participants are introduced to established study designs and study elements, as well as to modern study concepts and observational designs to address clinical questions. Another focus is on patient perspectives and patient preference studies.
ObjectiveParticipants will learn about alternatives to classic trial designs such as advanced study types and patient involvement and will integrate them into their own clinical study planning at the end of the module.

The course enables participants to...

1. describe the drug approval process, with a focus on Phase III clinical trials, identify the shortcomings of Phase III trials, and describe the strengths and limitations of Phase IV (observational drug safety) research.

2. identify and describe advanced study designs in observational research, explain the advantages and disadvantages of these designs, and identify what research questions are most suited to the advanced research questions.

3. explain the importance of randomisation in the assessment of moderate treatment effects, understand the principles of streamlined clinical trial design, understand how novel data sources can be used to provide reliable randomised evidence.

4. understand patient perspective as an integral part of clinical trials and clinical decision-making, understand the research process of a patient preference study, and recognise the similarity of the scientific principles of preferences studies with other study types.

5. describe the difference between including versus involving patient and family stakeholders in research studies, identify different ways to involve patient stakeholders into research, name ethical principles underlying the involvement of patient stakeholders in research.

6. describe how advanced study types and/or patient perspectives can be integrated into their individual clinical research planning.