Klaus Eyer: Catalogue data in Autumn Semester 2020

Name Dr. Klaus Eyer
E-mailklaus.eyer@pharma.ethz.ch
DepartmentChemistry and Applied Biosciences
RelationshipAssistant Professor

NumberTitleECTSHoursLecturers
529-0043-01LAnalytical Strategy Information 6 credits3GR. Zenobi, M. Badertscher, K. Eyer, S. Giannoukos, D. Günther
AbstractProblem-oriented development of analytical strategies and solutions.
ObjectiveAbility to create solutions for particular analytical problems.
ContentIndividual development of strategies for the optimal application of chemical, biochemical, and physico-chemical methods in analytical chemistry solving predefined problems. Experts from industry and administration present particular problems in their field of activity.
Principles of sampling.
Design and application of microanalytical systems.
Lecture notesCopies of problem sets and solutions will be distributed free fo charge
Prerequisites / NoticePrerequisites:
529-0051-00 "Analytical Chemistry I (3. Semester)"
529-0058-00 "Analytical Chemistry II (4. Semester)"
(or equivalent)
535-0011-00LDrug Seminar Restricted registration - show details
The course is reserved for students registered in the Master's programme in Pharmacy or in Pharmaceutical Sciences
5 credits9SK. Eyer, K.‑H. Altmann, S. M. Ametamey, A. Burden, M. Detmar, C. Halin Winter, J. Hall, S.‑D. Krämer, J.‑C. Leroux, C. Müller, V. I. Otto, U. Quitterer, R. Schibli, G. Schneider, C. Steuer
AbstractThe course provides a platform for the investigation, presentation and discussion of a topic with relevance to the field of pharmaceutical sciences. Students work in small groups on a chosen topic, they write a mini-review and present their work on a one day symposium.
ObjectiveThe main objectives of this course are:

- students develop their scientific reflection (Critical Thinking) and working skills by working independently on a relevant pharmaceutical topic
- students gain in-depth knowledge of the topic investigated
- students train their scientific writing and presentation skills
- students train their ability to plan a project and work in a team
ContentThe Course Drug Seminar takes place during the first 7 weeks of the 1. Master semester. It is a compulsory course of the MSc Pharmacy curriculum and an elective course in the MSc PharmSciences.

The course provides a platform for the investigation, presentation and discussion of a topic with relevance to the field of pharmaceutical sciences.

During the course, students work in small teams on a topic of their choice and elaborate a written mini-review and an oral presentation. Each team is tutored by a lecturer of the Institute of Pharmaceutical Sciences. The work is mainly based on literature search / review, but may also involve conducting interviews or site visits, if appropriate. The final presentations of all groups will take place in the framework of a dedicated Symposium held in the middle of the semester.
Prerequisites / NoticeOnly for students of MSc Pharmacy and MSc Pharmaceutical Sciences.
535-0810-00LGene Technology2 credits2GK. Eyer, J. Scheuermann
AbstractThe course gives a description and summary of the field of gene technology and its pharmaceutical applications. The course focuses on important methods and technologies and their application for genomic, transcriptomic and proteomic analyses in human biology.
ObjectiveThe course gives an overview of current state-of-the art and advancement in the fields of gene technology. Herein, the course focuses on genomic, transcriptomic and proteomic analysis and their uses in drug discovery and biomedical applications. The course is structured into lectures and practical examples drawn from the research field. Upon completion, the students are familiar and know current state-of-the art of methods and applications, but are also able to classify, contrast and apply different strategies and methods within the field of gene technology. The course is suited for advanced undergraduate and early graduate students in pharmaceutical sciences or related fields.
ContentI) Genomics and transcriptomics

Methods and Techniques:
• Recombinant DNA technology
• Next generation sequencing methods, sequencing of genomes
• CRISPR technology
Application to human biology:
• Functional genomics/transcriptomics
• Principles of cancer, genetic diseases
• Therapies: cell-based therapies/gene therapies/DNA and RNA vaccination

II) Proteomics

Methods and Techniques:
• Protein cloning and expression
• The antibody molecule
• Measurement and determination of biomolecular interactions
• Protein characterization and engineering
• Modifications and radioactive labelling
Application to human biology:
• Protein therapeutics
• Proteomic approaches for identification of novel disease-related targets and biomarkers

III) Drug discovery: Protein-based libraries

•Immune repertoire mining
•Display and selection technologies
1. antibody phage display
2. other polypeptide display technologies
3. small-molecules display: DNA-encoded chemical libraries