Bill Morandi: Catalogue data in Spring Semester 2022

Name Prof. Dr. Bill Morandi
FieldSynthetic Organic Chemistry
Address
Professur Synthetische Org. Chemie
ETH Zürich, HCI G 313
Vladimir-Prelog-Weg 1-5/10
8093 Zürich
SWITZERLAND
Telephone+41 44 633 21 76
E-mailbill.morandi@org.chem.ethz.ch
DepartmentChemistry and Applied Biosciences
RelationshipFull Professor

NumberTitleECTSHoursLecturers
529-0222-00LOrganic Chemistry II3 credits2V + 1UB. Morandi, J. W. Bode
AbstractThis course builds on the material learned in Organic Chemistry I or Organic Chemistry II for Biology/Pharmacy Students. Topics include advanced concepts and mechanisms of organic reactions and introductions to pericyclic and organometallic reactions. The basics or retro- and forward synthesis are also introduced.
ObjectiveGoals of this course include a deeper understanding of basic organic reactions and mechanisms as well as advanced transformations. Reactive intermediates including carbenes and nitrenes are covered, along with methods for their generation and use in complex molecule synthesis. Frontier molecular orbital theory (FMO) is introduced and used to rationalize pericyclic reactions including Diels Alder reactions, cycloadditions, and rearrangements (Cope, Claisen). The basic concepts and key reactions of catalytic organometallic chemistry, which are key methods in modern organic synthesis, are introduced, with an emphasis on their catalytic cycles and elementary steps. All of these topics are combined in an overview of strategies for complex molecule synthesis, with specific examples from natural product derived molecules used as medicines.
ContentRedox neutral reactions and rearrangements, advanced transformations of functional groups and reaction mechanisms, carbenes and nitrenes, frontier molecular orbital theory (FMO), cycloadditions and pericyclic reactions, introduction to organometallic chemistry and catalytic cross couplings, protecting groups, retrosynthetic analysis of complex organic molecules, planning and execution of multi-step reactions.
Lecture notesThe lecture notes and additional documents including problem sets are available as PDF files online, without charge. Link: https://morandi.ethz.ch/education.html
LiteratureClayden, Greeves, and Warren. Organic Chemistry, 2nd Edition. Oxford University Press, 2012.
529-0230-00LInorganic and Organic Chemistry I Restricted registration - show details
Enrolment only possible up to the beginning of the semester.
8 credits12PB. Morandi
AbstractLaboratory Course in Inorganic and Organic Chemistry I
ObjectiveIntroduction into basic techniques used in the organic laboratory. Understanding organic reactions through experiments.
ContentPart I: Basic operations such as the isolation, purification and characterization of organic compounds: distillation, extraction, chromatography, crystallization, IR (UV/1H-NMR)-spectroscopy for the identification of the constituion of organic compounds.

Part II: Organic reactions: preparative chemistry. From simple, one-step to multistep syntheses. Both classic and modern reactions will be performed.

Part III: Preparation of a chiral, enantiomerically pure ligand for asymmetric catalysis (together with AOCP II)
Literature- R. K. Müller, R. Keese: "Grundoperationen der präparativen organischen Chemie"; J. Leonard, B. Lygo, G. Procter: "Praxis der Organischen Chemie" (Übersetzung herausgegeben von G. Dyker), VCH, Weinheim, 1996, ISBN 3-527-29411-2.
Prerequisites / NoticePrerequisites:
- Praktikum Allgemeine Chemie (1. Semester, 529-0011-04/05)
- Vorlesung Organische Chemie I (1. Semester, 529-0011-03)

Safety conceptt: https://chab.ethz.ch/studium/bachelor1.html