Bill Morandi: Katalogdaten im Frühjahrssemester 2022 |
| Name | Herr Prof. Dr. Bill Morandi |
| Lehrgebiet | Synthetische Organische Chemie |
| Adresse | Professur Synthetische Org. Chemie ETH Zürich, HCI G 313 Vladimir-Prelog-Weg 1-5/10 8093 Zürich SWITZERLAND |
| Telefon | +41 44 633 21 76 |
| bill.morandi@org.chem.ethz.ch | |
| Departement | Chemie und Angewandte Biowissenschaften |
| Beziehung | Ordentlicher Professor |
| Nummer | Titel | ECTS | Umfang | Dozierende | |
|---|---|---|---|---|---|
| 529-0222-00L | Organic Chemistry II | 3 KP | 2V + 1U | B. Morandi, J. W. Bode | |
| Kurzbeschreibung | This course builds on the material learned in Organic Chemistry I or Organic Chemistry II for Biology/Pharmacy Students. Topics include advanced concepts and mechanisms of organic reactions and introductions to pericyclic and organometallic reactions. The basics or retro- and forward synthesis are also introduced. | ||||
| Lernziel | Goals of this course include a deeper understanding of basic organic reactions and mechanisms as well as advanced transformations. Reactive intermediates including carbenes and nitrenes are covered, along with methods for their generation and use in complex molecule synthesis. Frontier molecular orbital theory (FMO) is introduced and used to rationalize pericyclic reactions including Diels Alder reactions, cycloadditions, and rearrangements (Cope, Claisen). The basic concepts and key reactions of catalytic organometallic chemistry, which are key methods in modern organic synthesis, are introduced, with an emphasis on their catalytic cycles and elementary steps. All of these topics are combined in an overview of strategies for complex molecule synthesis, with specific examples from natural product derived molecules used as medicines. | ||||
| Inhalt | Redox neutral reactions and rearrangements, advanced transformations of functional groups and reaction mechanisms, carbenes and nitrenes, frontier molecular orbital theory (FMO), cycloadditions and pericyclic reactions, introduction to organometallic chemistry and catalytic cross couplings, protecting groups, retrosynthetic analysis of complex organic molecules, planning and execution of multi-step reactions. | ||||
| Skript | The lecture notes and additional documents including problem sets are available as PDF files online, without charge. Link: https://morandi.ethz.ch/education.html | ||||
| Literatur | Clayden, Greeves, and Warren. Organic Chemistry, 2nd Edition. Oxford University Press, 2012. | ||||
| 529-0230-00L | Anorganische und Organische Chemie I  Elektronische Belegung nur möglich bis Semesterbeginn. | 8 KP | 12P | B. Morandi | |
| Kurzbeschreibung | Praktikum in Anorganischer und Organischer Chemie I | ||||
| Lernziel | Schulung in experimenteller Arbeitstechnik. Verständnis organisch-chemischer Reaktionen durch Experimente. | ||||
| Inhalt | Teil I: (ca. 1. Semesterdrittel): Grundoperationen: Erlernen der wichtigsten Grundoperationen in der Reinigung, Trennung, Isolierung und Analytik organischer Verbindungen: Fraktionierende Destillation; Extraktive Trennverfahren; Chromatographie; Kristallisation; IR- (evtl. UV-, 1 H-NMR)-spektroskopische Verfahren zur Strukturermittlung. Teil II: (2. Semesterdrittel): Organisch-chemische Reaktionen: Herstellung organischer Präparate. Anfänglich ein-, später mehrstufige Synthesen. Präparate beinhalten breite Palette an klassischen und modernen Reaktionstypen. Teil III: (3. Semesterdrittel): Synthese eines chiralen, enantiomerenreinen Liganden fuer die asymmetrische Katalyse (zusammen mit AOCP II) | ||||
| Literatur | - R. K. Müller, R. Keese: "Grundoperationen der präparativen organischen Chemie"; J. Leonard, B. Lygo, G. Procter: "Praxis der Organischen Chemie" (Übersetzung herausgegeben von G. Dyker), VCH, Weinheim, 1996, ISBN 3-527-29411-2. | ||||
| Voraussetzungen / Besonderes | Voraussetzungen: - Praktikum Allgemeine Chemie (1. Semester, 529-0011-04/05) - Vorlesung Organische Chemie I (1. Semester, 529-0011-03) Schutzkonzept: https://chab.ethz.ch/studium/bachelor1.html | ||||