Bill Morandi: Catalogue data in Spring Semester 2023 |
| Name | Prof. Dr. Bill Morandi |
| Field | Synthetic Organic Chemistry |
| Address | Professur Synthetische Org. Chemie ETH Zürich, HCI G 313 Vladimir-Prelog-Weg 1-5/10 8093 Zürich SWITZERLAND |
| Telephone | +41 44 633 21 76 |
| bill.morandi@org.chem.ethz.ch | |
| Department | Chemistry and Applied Biosciences |
| Relationship | Full Professor |
| Number | Title | ECTS | Hours | Lecturers | |
|---|---|---|---|---|---|
| 529-0222-00L | Organic Chemistry II | 3 credits | 2V + 1U | B. Morandi, J. W. Bode | |
| Abstract | This course builds on the material learned in Organic Chemistry I or Organic Chemistry II for Biology/Pharmacy Students. Topics include advanced concepts and mechanisms of organic reactions and introductions to pericyclic and organometallic reactions. The basics or retro- and forward synthesis are also introduced. | ||||
| Learning objective | Goals of this course include a deeper understanding of basic organic reactions and mechanisms as well as advanced transformations. Reactive intermediates including carbenes and nitrenes are covered, along with methods for their generation and use in complex molecule synthesis. Frontier molecular orbital theory (FMO) is introduced and used to rationalize pericyclic reactions including Diels Alder reactions, cycloadditions, and rearrangements (Cope, Claisen). The basic concepts and key reactions of catalytic organometallic chemistry, which are key methods in modern organic synthesis, are introduced, with an emphasis on their catalytic cycles and elementary steps. All of these topics are combined in an overview of strategies for complex molecule synthesis, with specific examples from natural product derived molecules used as medicines. | ||||
| Content | Redox neutral reactions and rearrangements, advanced transformations of functional groups and reaction mechanisms, carbenes and nitrenes, frontier molecular orbital theory (FMO), cycloadditions and pericyclic reactions, introduction to organometallic chemistry and catalytic cross couplings, protecting groups, retrosynthetic analysis of complex organic molecules, planning and execution of multi-step reactions. | ||||
| Lecture notes | The lecture notes and additional documents including problem sets are available as PDF files online, without charge. Link: https://morandi.ethz.ch/education.html | ||||
| Literature | Clayden, Greeves, and Warren. Organic Chemistry, 2nd Edition. Oxford University Press, 2012. | ||||
| 529-0230-00L | Inorganic and Organic Chemistry I  | 8 credits | 12P | B. Morandi | |
| Abstract | Laboratory Course in Inorganic and Organic Chemistry I | ||||
| Learning objective | Introduction into basic techniques used in the organic laboratory. Understanding organic reactions through experiments. | ||||
| Content | Part I: Basic operations such as the isolation, purification and characterization of organic compounds: distillation, extraction, chromatography, crystallization, IR (UV/1H-NMR)-spectroscopy for the identification of the constituion of organic compounds. Part II: Organic reactions: preparative chemistry. From simple, one-step to multistep syntheses. Both classic and modern reactions will be performed. Part III: Preparation of a chiral, enantiomerically pure ligand for asymmetric catalysis (together with AOCP II) | ||||
| Literature | - R. K. Müller, R. Keese: "Grundoperationen der präparativen organischen Chemie"; J. Leonard, B. Lygo, G. Procter: "Praxis der Organischen Chemie" (Übersetzung herausgegeben von G. Dyker), VCH, Weinheim, 1996, ISBN 3-527-29411-2. | ||||
| Prerequisites / Notice | Prerequisites: - Praktikum Allgemeine Chemie (1. Semester, 529-0011-04/05) - Vorlesung Organische Chemie I (1. Semester, 529-0011-03) | ||||
| 529-0299-00L | Organic Chemistry | 0 credits | 1.5K | J. W. Bode, E. M. Carreira, P. Chen, K. Lang, B. Morandi, H. Wennemers, R. Zenobi | |
| Abstract | Updates on Research and Contemporary Literature in Organic Chemistry and Chemical Biology. | ||||
| Learning objective | Problem solving in organic chemistry and chemical biology. | ||||