Jörg Scheuermann: Catalogue data in Autumn Semester 2021

Name PD Dr. Jörg Scheuermann
FieldPharmaceutical Sciences
Inst. f. Pharmazeutische Wiss.
ETH Zürich, HCI G 396.4
Vladimir-Prelog-Weg 1-5/10
8093 Zürich
Telephone+41 44 633 77 74
Fax+41 44 633 13 58
DepartmentChemistry and Applied Biosciences

511-0000-00LDrug Discovery and Development Restricted registration - show details
Only for MSc Pharmaceutical Sciences.
2 credits1G + 1SJ. Hall, U. Thibaut, K.‑H. Altmann, M. Arand, J. Scheuermann, R. Schibli, H. U. Zeilhofer
AbstractThis course provides an overview over the concepts and processes employed in today's drug discovery and development. It has an introductory character but will also provide more detailed insights employing real life examples. The course combines lectures and interactive elements with active participation of the students.
- Understand the drug discovery process and can explain major approaches and relevant technical terms (for details see lecture notes).
- Understand and appreciate the content and timing of drug development process steps, development phases and decision criteria.
- Understand the concepts underlying drug product development through all the phases from preclinical and clinical development to regulatory submission, approval and market launch.
- Can differentiate between small molecule drug development and biological drug development.
- Understand the most important differences between legal and regulatory requirements for drug development and approval for the major markets EU and USA.
ContentCourse unit comprises weekly lectures covering the early phases of target and drug discovery (535-0901-01 S "From A to Z in Drug Discovery and Development I") with group work in the area of Drug Development (511-0000-00 G). Group work is 2 full days (Days 1 and 2) and comprises: introduction to the entire suite of drug product development processes in the pharmaceutical industry, covering: preclinical research and development, clinical development, regulatory processes and market launch.
R&D support processes such as project management, quality management, pharmacovigilance and pharmacoeconomics will be covered as well as organizational and governance aspects of the pharmaceutical industry. In addition, important success factors for a later career in the pharmaceutical industry will be discussed and highlighted at the end of the course.
Lecture notesWill be published on "mystudies"
LiteratureG. Nahler (Hrsg.) Dictionary of pharmaceutical medicine, Springer, Wien, 2013 (3rd edition)
Further readings will be listed in the lecture notes.
Prerequisites / NoticeThis course provides the essential basic knowledge required for the industry-specific modules of the spring semester.

Safety conceptt: https://chab.ethz.ch/studium/bachelor1.html
511-1003-00LGene Technology (Crash Course) Restricted registration - show details
Only for Pharmaceutical Sciences MSc.

Obligatory course if assigned by the Admission committee.
1 credit1SJ. Scheuermann
AbstractThe course enables the student to understand and and apply the general concepts of gene technology, including recombinant DNA technology and its application in genomics, transcriptomics and proteomics. Protein cloning, expression and modifications and bimolecular interactions will be discussed. The concept of display technology and its applications in the field of drug discovery will be presented.
ObjectiveThe students remember and understand:
1. The tools of recombinant DNA technology
2. Next generation sequencing approaches and their relevance for -omics projects
3. Protein cloning, expression, modification/labelling and oligomerization
4. Thermodynamic and kinetic affinity constants in bimolecular reactions
5. Basic structure of the antibody molecule
6. Concepts of antibody phage technology and antibody engineering
7. Construction of antibody-, peptide- or small molecule libraries and affintiy-based selection methodologies
ContentI) Genomics:
recombinant DNA technology
methods to sequence genomes
application to human biology
Transcriptomics / Proteomics
II) Proteins:
protein cloning and expression
homo- and heterodimerization
chemical modifications and radioactive labelling
detection of bimolecular interactions
affinity constant and experimental measurement
kinetic association and dissociation constants
III) Display technology:
the antibody molecule, CDRs, basics of antibody engineering
antibody phage display and selection methodologies
construction of antibody libraries
other display technologies (peptide display, DNA-encoded chemical libraries)
Lecture notesslides and script used for the course and literature for reading and discussions will be made available online.
Literaturededicated chapters of:
S.B. Primrose and R.M. Twyman 'Principles of Gene Manipulation and Genomics', 7th ed. (2006) Blackwell Science
dedicated articles will be announced
Prerequisites / Noticeadmission to MSc in Pharmaceutical Sciences
535-0001-00LIntroduction to Pharmaceutical Sciences I Restricted registration - show details 2 credits2VJ. Hall, K.‑H. Altmann, M. Detmar, C. Halin Winter, J.‑C. Leroux, U. Quitterer, J. Scheuermann, R. Schibli, H. U. Zeilhofer
AbstractFirst identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences, which are focused on within the first two years as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities.
ObjectiveFirst identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities.
ContentIntroduction to Pharmaceutical Sciences by selected milestones of research and development. Overview on research activities at the Institute of Pharmaceutical Sciences that is focussed on drug delivery and development (from concepts to prototypes). Sensitization for communication skills and information management. Demonstration of job opportunities in community pharmacies, in the hospital, in industry, and in the public sector by experts in the different fields.
Lecture notesHandouts for individual lectures.
Prerequisites / NoticeInteractive teaching
535-0011-00LDrug Seminar Restricted registration - show details
The course is reserved for students registered in the Master's programme in Pharmacy or in Pharmaceutical Sciences
5 credits9SA. Burden, K.‑H. Altmann, M. Detmar, K. Eyer, C. Halin Winter, J. Hall, S.‑D. Krämer, J.‑C. Leroux, C. Müller, V. I. Otto, U. Quitterer, J. Scheuermann, R. Schibli, C. Steuer
AbstractThe course provides a platform for the investigation, presentation and discussion of a topic with relevance to the field of pharmaceutical sciences. Students work in small groups on a chosen topic, they write a mini-review and present their work on a one day symposium.
ObjectiveThe main objectives of this course are:

- students develop their scientific reflection (Critical Thinking) and working skills by working independently on a relevant pharmaceutical topic
- students gain in-depth knowledge of the topic investigated
- students train their scientific writing and presentation skills
- students train their ability to plan a project and work in a team
ContentThe Course Drug Seminar takes place during the first 7 weeks of the 1. Master semester. It is a compulsory course of the MSc Pharmacy curriculum and an elective course in the MSc PharmSciences.

The course provides a platform for the investigation, presentation and discussion of a topic with relevance to the field of pharmaceutical sciences.

During the course, students work in small teams on a topic of their choice and elaborate a written mini-review and an oral presentation. Each team is tutored by a lecturer of the Institute of Pharmaceutical Sciences. The work is mainly based on literature search / review, but may also involve conducting interviews or site visits, if appropriate. The final presentations of all groups will take place in the framework of a dedicated Symposium held in the middle of the semester.
Prerequisites / NoticeOnly for students of MSc Pharmacy and MSc Pharmaceutical Sciences.
535-0239-00LPractical Course in Medicinal Chemistry Restricted registration - show details 3 credits7PJ. Hall, M. Detmar, C. Halin Winter, J. Scheuermann
AbstractThe course comprises experiments relating to concepts of medicinal chemistry including statistical processing, fitting of experimental data, computer modeling of protein structures, experimental measurement of affinity constants and kinetic dissociation constants for protein ligands. The chemical stability of a drug will be studied. Basic gene cloning and protein expression will be introduced.
ObjectiveKnowledge of experimental methods in drug discovery and development
ContentCharacterisation of the biophysical and biological properties of drugs.
Lecture notesScripts
LiteratureOriginal literature
Prerequisites / NoticeRequirements:
Laboratory course in Pharmaceutical Anaytics;
Lecture Medicinal Chemistry I in the same semester or earlier.

Safety conceptt: https://chab.ethz.ch/studium/bachelor1.html
535-0300-00LMolecular Mechanisms of Drug Actions and Targets Restricted registration - show details
Number of participants limited to 24.
2 credits1VJ. Scheuermann
AbstractOn average one drug per year is withdrawn from the market. Using selected examples of such drug failures, the course aims at analyzing and discussing the present explanations of drug actions as well as the design and predictive power of animal models and clinical trials. In addition, the ethical, societal, and economical expectations in new drugs shall be reflected and discussed.
ObjectiveTo develop a critical understanding of the relevance and limitations of the current approaches to explaining and anticipating drug effects. To critically appraise the ethical, societal, economical and political expectations in the development of new drugs.
ContentIn December 2006, Pfizer stopped a large phase III study on the use of Torcetrapib for the prevention of atherosclerosis and cardiovascular disease. 800 million $ in development costs and 21 billion $ in stocks were annihilated overnight. The failure of Torcetrapib has pinpointed the limitations of an extremely reductionist view of atherosclerosis and it's prevention by drug therapy. It has also highlighted what high expectations we have in a safe and wide applicability of drugs and of their economical success.
Torcetrapib is not a single case. In the last 10 years, on average one drug per year was withdrawn from the market due to lack of efficacy, unexpected side effects or toxicity. This clearly shows that the common investigations and the modern understanding of drug actions are often not sufficient to predict the effects a drug will have in large patient populations.
These are the topics of the present course. Using three particularly informative examples of drug failures, the problems encountered and the concepts and informative value of preclinical and clinical studies will be analyzed and discussed. Furthermore, the ethical, societal, economical and political expectations in new drugs shall be reflected.
Lecture notesLecture slides and literature for reading and discussions will be available online.
Prerequisites / NoticeRequirements: basic knowledge in Medicinal Chemistry and Pharmacology. Ability to read and understand scientific publications written in English.
535-0810-00LGene Technology2 credits2GK. Eyer, J. Scheuermann
AbstractThe course gives a description and summary of the field of gene technology and its pharmaceutical applications. The course focuses on important methods and technologies and their application for genomic, transcriptomic and proteomic analyses in human biology.
ObjectiveThe course gives an overview of current state-of-the art and advancement in the fields of gene technology. Herein, the course focuses on genomic, transcriptomic and proteomic analysis and their uses in drug discovery and biomedical applications. The course is structured into lectures and practical examples drawn from the research field. Upon completion, the students are familiar and know current state-of-the art of methods and applications, but are also able to classify, contrast and apply different strategies and methods within the field of gene technology. The course is suited for advanced undergraduate and early graduate students in pharmaceutical sciences or related fields.
ContentI) Genomics and transcriptomics

Methods and Techniques:
• Recombinant DNA technology
• Next generation sequencing methods, sequencing of genomes
• CRISPR technology
Application to human biology:
• Functional genomics/transcriptomics
• Principles of cancer, genetic diseases
• Therapies: cell-based therapies/gene therapies/DNA and RNA vaccination

II) Proteomics

Methods and Techniques:
• Protein cloning and expression
• The antibody molecule
• Measurement and determination of biomolecular interactions
• Protein characterization and engineering
• Modifications and radioactive labelling
Application to human biology:
• Protein therapeutics
• Proteomic approaches for identification of novel disease-related targets and biomarkers

III) Drug discovery: Protein-based libraries

•Immune repertoire mining
•Display and selection technologies
1. antibody phage display
2. other polypeptide display technologies
3. small-molecules display: DNA-encoded chemical libraries
Lecture notesThe lecture series follows the above-described content, and the students are provided with the lecture slides and additional notes. The additional notes are needed for the in-depth study of the individual topics, and to set the frame and content of the in-class group work of the chosen examples.
Subject-specific CompetenciesConcepts and Theoriesassessed
Techniques and Technologiesassessed
Method-specific CompetenciesDecision-makingassessed
Personal CompetenciesCreative Thinkingassessed
Critical Thinkingassessed
535-0901-00LFrom A to Z in Drug Discovery and Development1 credit2SJ. Hall, K.‑H. Altmann, M. Arand, J. Scheuermann, R. Schibli, H. U. Zeilhofer
AbstractThe lecture series takes place at the ETH Hönggerberg and covers a variety of major activities involved in drug discovery: selecting drug targets, technologies used in drug discovery, small, medium and large drugs, objectives of the medicinal chemist, assessing drug safety, principles of personalized medicine, designing clinical trials, how intellectual property is protected, as well as others.
ObjectiveThe objective of the course is to gain a global understanding of most of the important phases in the discovery and development of modern synthetic and biological drugs, from the first activities to clinical trials. The lecture is intended for students that have an interest in the area and/or may consider a career working in drug discovery. This lecture course complements knowledge and experience gained in the research project performed by the PhD student.
ContentThirteen two hour lectures for life-science PhD students and students of the Pharmaceutical Sciences Master, given by experts from the ETH, UZH, USZ and the pharmaceutical industry.
Introduction to the modern drug discovery process - Principles of drug pharmacokinetics and drug metabolism - Computer sciences in drug discovery - Drug targets - In vitro methods in drug discovery - Natural products in drug discovery - Medicinal chemistry: Chemical lead selection/optimization - Antibodies and therapeutic proteins: Targets and drugs - In vivo molecular imaging in drug discovery - Drug formulation: Key development consideration, Current new APIs challenges and FDA rising standards - Preclinical safety, adverse drug events and drug-drug interactions - Clinical development steps including trial design - Intellectual property in drug discovery and development
Lecture notesScripts to be uploaded into ILIAS
LiteratureTo be distributed during the lecture
Prerequisites / NoticeFormally none, but a basic understanding in biochemistry, physiology and chemistry is highly desirable as it will certainly help to get the most from the lectures.