Alvar Diego Gossert: Katalogdaten im Frühjahrssemester 2018

NameHerr Dr. Alvar Diego Gossert
Adresse
Dep. Biologie
ETH Zürich, HPP L 25.2
Hönggerbergring 64
8093 Zürich
SWITZERLAND
Telefon+41 44 633 34 55
E-Mailalvar.gossert@biol.ethz.ch
URLhttps://bnsp.ethz.ch/people/gossert.html
DepartementBiologie
BeziehungDozent

NummerTitelECTSUmfangDozierende
551-0434-00LNMR Spectroscopy in Biology Belegung eingeschränkt - Details anzeigen
Number of participants limited to 6.

The enrolment is done by the D-BIOL study administration.
6 KP7GF. Allain, A. D. Gossert, K. Wüthrich
KurzbeschreibungIn this block course, students actively participate in ongoing research projects in the research groups of Profs. Allain, Wider and Wüthrich. The students will be tutored in their experimental work by doctoral or postdoctoral students. In addition, the course includes specific lectures that provide the theoretical background for the experimental work, as well as excercises and literature work.
LernzielThe course provides first "hands on" insight into applications of NMR spectroscopy in biological sciences. The course should enable the students to understand the potential and limitations of NMR applied to biological problems.
InhaltThe topics include studies of proteins, RNA and protein-RNA interactions,

Participation in one of the following projects will be possible:
- NMR of RNA
- NMR of several protein-RNA complexes (hnRNPF, nPTB, SR proteins)
- NMR studies of glycoproteins
- dynamics of protein-RNA complexes
- Segmental isotopic labeling to study multidomain proteins
-Structural and dynamic properties of FtsZ, the bacterial homolog of tubulin
- investigations of the ubiquitinom
- NMR Methods Development
SkriptNo script
LiteraturLists of individual reading assignments will be handed out.
551-1414-00LMolecular and Structural Biology V: Studying Macromolecules by NMR and EPR4 KP2VF. Allain, A. D. Gossert, G. Jeschke, K. Wüthrich
KurzbeschreibungThe course provides an overview of experimental methods for the determination of structures of macromolecules at atomic resolution in solution. The two main methods used are Nuclear Magnetic Resonance (NMR) spectroscopy and Electron Paramagnetic Resonance (EPR) spectroscopy.
LernzielInsight into the methodology, areas of application and limitations of these two methods for the structure determination of biological macromolecules. Practical exercises with spectra to have hands on understanding of the methodology.
InhaltPart I: Methods for the determination of protein structures in solution using nuclear magnetic resonance (NMR) spectroscopy. Experimental approaches to the characterization of intramolecular dynamics of proteins.
Part II: NMR methods for structurally characterizing RNA and protein-RNA complexes.
Part III: EPR of biomolecules
Literatur1) Wüthrich, K. NMR of Proteins and Nucleic Acids, Wiley-Interscience.
2) Dominguez et al, Prog Nucl Magn Reson Spectrosc. 2011 Feb;58(1-2):1-61.
3) Duss O et al, Methods Enzymol. 2015;558:279-331.
551-1616-00LMethods for Studies of Biological Macromolecules by NMR1 KP2SA. D. Gossert
KurzbeschreibungIn this course topics relevant to structure determination of biological macromolecules by solution state NMR spectroscopy are discussed. The course is tailored to advanced students, mainly PhD students and postdocs in structural biology who have experience with applications of NMR spectroscopy. The individual participants present various topics in form of a seminar.
LernzielThe students will actively participate in the course which is held in the form of a seminar. Individual students will prepare particular topics of the course based on literature references and present the material in form of a seminar to their fellow students. In short, the students learn to actively participate in discussions and to prepare a presentation of a scientific topic which was mostly unknown to them before.