Michael Nash: Katalogdaten im Herbstsemester 2020

NameHerr Prof. Dr. Michael Nash
LehrgebietEngineering von Synthetischen Systemen
Engineering v. Synthetischen Syst.
ETH Zürich, BSS H 41
Klingelbergstrasse 48
4056 Basel
BeziehungAusserordentlicher Professor

636-0102-00LAdvanced Bioengineering4 KP3SS. Panke, Y. Benenson, P. S. Dittrich, M. Fussenegger, A. Hierlemann, M. H. Khammash, A. Moor, D. J. Müller, M. Nash, R. Platt, J. Stelling, B. Treutlein
KurzbeschreibungThis course provides an overview of modern concepts of bioengineering across different levels of complexity, from single molecules to systems, microscaled reactors to production environments, and across different fields of applications
LernzielStudents will be able to recognize major developments in bioengineering across different organisms and levels of complexity and be able to relate it to major technological and conceptual advances in the underlying sciences.
InhaltMolecular and cellular engineering; Synthetic biology: Engineering strategies in biology; from single molecules to systems; downscaling bioengineering; Bioengineering in chemistry, pharmaceutical sciences, and diagnostics, personalized medicine.
SkriptHandouts during class
LiteraturWill be announced during the course
636-0550-00LBiomolecular Nanotechnology4 KP2V + 1UM. Nash
KurzbeschreibungBiomolecular nanotechnology is a broad field that focuses on the study and science of biological materials including DNA, RNA and proteins at length scales below 10 nm. This is a broad overview of the topic with a focus on current research themes.
LernzielThe objective is to familiarise the students with a broad range of topics related to biotechnology, nanotechnology, and biophysics with a focus on current research and reading of scientific literature.
InhaltIntroduction to biomacromolecules; Measurement techniques for characterisation of biomacromolecules; Fundamentals of molecular recognition; Recombinant DNA; Protein engineering; Directed evolution; Protein folding; Polymers; Elastin-like polypeptides; Intelligent materials; Spatially localized hydrogels; Mechanical properties of proteins and macromolecules; Single-molecule force spectroscopy
LiteraturRepresentative literature:
(1) Alberts, Molecular Biology (Ch.2 Cellular chemistry).
(2) Ratner, Biomaterials Science (Ch. 2.3, 2.4 Polymers & hydrogels).
(3) Walsh, Protein Biochemistry, (Ch. 2, Protein Structure).
(4) Nath et. al. Analytical chemistry, 74(3): 504-509, 2002.
(5) DeMonte, D., et. al. Proteins DOI: 10.1002/prot.24320, 2013.
(6) Feldhaus, M.J., et al. Nature Biotechnology 21 (2): 163–70, 2003.
(7) Link, A.J., et al. PNAS 103 (27): 10180–85, 2006.
(8) Chen, I. et al. PNAS 108 (28): 11399–404, 2011.
(9) Marín-Navarro, J., et. al. PloS One 10 (12). journals.plos.org: e0144289, 2015.
(10) Christensen, T. et al. Biomacromolecules 14 (5): 1514–19, 2013.
(11) Shimoboji, T., et al. PNAS. 99(26): 16592-16596, 2002.
(12) Puchner, E.M. et al. PNAS. 105(36): 13385–13390, 2008.
(13) Dietz, H., et al. PNAS 103 (5): 1244–47, 2006.