Michael Nash: Catalogue data in Autumn Semester 2019
|Name||Prof. Dr. Michael Nash|
|Field||Engineering of Synthetic Systems|
Engineering v. Synthetischen Syst.
ETH Zürich, Dept. Biosysteme Basel
|Department||Biosystems Science and Engineering|
|636-0102-00L||Advanced Bioengineering||4 credits||3S||Y. Benenson, P. S. Dittrich, M. Fussenegger, A. Hierlemann, M. H. Khammash, D. J. Müller, M. Nash, R. Platt, J. Stelling, B. Treutlein|
|Abstract||This course provides an overview of modern concepts of bioengineering across different levels of complexity, from single molecules to systems, microscaled reactors to production environments, and across different fields of applications|
|Objective||Students will be able to recognize major developments in bioengineering across different organisms and levels of complexity and be able to relate it to major technological and conceptual advances in the underlying sciences.|
|Content||Molecular and cellular engineering; Synthetic biology: Engineering strategies in biology; from single molecules to systems; downscaling bioengineering; Bioengineering in chemistry, pharmaceutical sciences, and diagnostics, personalized medicine.|
|Lecture notes||Handouts during class|
|Literature||Will be announced during the course|
|636-0550-00L||Biomolecular Nanotechnology||3 credits||3V||M. Nash|
|Abstract||Biomolecular nanotechnology is a broad field that focuses on the study and science of biological materials including DNA, RNA and proteins at length scales below 10 nm. This is a broad overview of the topic with a focus on current research themes.|
|Objective||The objective is to familiarise the students with a broad range of topics related to biotechnology, nanotechnology, and biophysics with a focus on current research and reading of scientific literature.|
|Content||Introduction to biomacromolecules; Measurement techniques for characterisation of biomacromolecules; Fundamentals of molecular recognition; Recombinant DNA; Protein engineering; Directed evolution; Protein folding; Polymers; Elastin-like polypeptides; Intelligent materials; Spatially localized hydrogels; Mechanical properties of proteins and macromolecules; Single-molecule force spectroscopy|
|Literature||Representative literature: |
(1) Alberts, Molecular Biology (Ch.2 Cellular chemistry).
(2) Ratner, Biomaterials Science (Ch. 2.3, 2.4 Polymers & hydrogels).
(3) Walsh, Protein Biochemistry, (Ch. 2, Protein Structure).
(4) Nath et. al. Analytical chemistry, 74(3): 504-509, 2002.
(5) DeMonte, D., et. al. Proteins DOI: 10.1002/prot.24320, 2013.
(6) Feldhaus, M.J., et al. Nature Biotechnology 21 (2): 163–70, 2003.
(7) Link, A.J., et al. PNAS 103 (27): 10180–85, 2006.
(8) Chen, I. et al. PNAS 108 (28): 11399–404, 2011.
(9) Marín-Navarro, J., et. al. PloS One 10 (12). journals.plos.org: e0144289, 2015.
(10) Christensen, T. et al. Biomacromolecules 14 (5): 1514–19, 2013.
(11) Shimoboji, T., et al. PNAS. 99(26): 16592-16596, 2002.
(12) Puchner, E.M. et al. PNAS. 105(36): 13385–13390, 2008.
(13) Dietz, H., et al. PNAS 103 (5): 1244–47, 2006.