Name | Herr Prof. Dr. Randall Platt |
Lehrgebiet | Biologisches Engineering |
Adresse | Professur Biologisches Engineering ETH Zürich, BSS J 19.1 Klingelbergstrasse 48 4056 Basel SWITZERLAND |
Telefon | +41 61 387 33 50 |
randall.platt@bsse.ethz.ch | |
Departement | Biosysteme |
Beziehung | Ausserordentlicher Professor |
Nummer | Titel | ECTS | Umfang | Dozierende | |
---|---|---|---|---|---|
636-0113-00L | Genome Engineering ![]() | 4 KP | 3V | R. Platt | |
Kurzbeschreibung | This course is both an introduction to genome engineering and also a highly interactive practical training on effectively reading, writing, and presenting in an academic context. | ||||
Lernziel | The objective of this course is to learn how gene editing technologies function at the molecular and cellular level and how they are applied in research and clinical settings. Students will be introduced to the history and motivation behind the discovery and development of transformative genome engineering technologies, and also gain insight into the ethical, safety, and regulatory facets shaping the field. This content will be explored by critically examining and discussing current literature in the field and devising a technology development plan. | ||||
Inhalt | The course content is comprised of lectures, discussions, and a project. Lectures in Genome Engineering will be technology-focused and incorporate: 1) historical context to motivate the need for developing the technology, 2) development of the technology from concept to robust tool, 3) methods to discover, characterize, and evaluate the technology, and 4) applications of the technology in basic and applied research. Primary research articles will be assigned each week, which will be followed by an in-class lecture and discussion. The course project will be team-based and entail devising a solution to a critical need in the field. Main topics: --Discovery and development of genome editing technologies --The prokaryotic adaptive immune system CRISPR-Cas --Genome engineering methods for generating genetically engineered model systems --Genotype-phenotype linkage via genetic screens --Massively paralleled perturbation and phenotyping --Gene editing tools as molecular recording devices --Gene editing tools as diagnostics and therapeutics | ||||
Skript | Made available through the course website. | ||||
Literatur | Assigned each week. Made available through the course website. | ||||
636-0301-00L | Current Topics in Biosystems Science and Engineering | 2 KP | 1S | R. Platt, N. Beerenwinkel, Y. Benenson, K. M. Borgwardt, P. S. Dittrich, M. Fussenegger, A. Hierlemann, D. Iber, M. H. Khammash, A. Moor, D. J. Müller, S. Panke, S. Reddy, T. Schroeder, T. Stadler, J. Stelling, B. Treutlein | |
Kurzbeschreibung | This seminar will feature invited lectures about recent advances and developments in systems biology, including topics from biology, bioengineering, and computational biology. | ||||
Lernziel | To provide an overview of current systems biology research. | ||||
Inhalt | The final list of topics will be available at http://www.bsse.ethz.ch/education/. | ||||
636-1004-AAL | Bio IV: Genetics Belegung ist NUR erlaubt für MSc Studierende, die diese Lerneinheit als Auflagenfach verfügt haben. Alle anderen Studierenden (u.a. auch Mobilitätsstudierende, Doktorierende) können diese Lerneinheit NICHT belegen. | 5 KP | 7R | R. Platt | |
Kurzbeschreibung | |||||
Lernziel | |||||
Literatur | Lewin, Genes XI, chapters: 3,15, 16, 19-23, 26-30 | ||||
636-1008-AAL | Bio Lab III: Molecular Biology I Belegung ist NUR erlaubt für MSc Studierende, die diese Lerneinheit als Auflagenfach verfügt haben. Alle anderen Studierenden (u.a. auch Mobilitätsstudierende, Doktorierende) können diese Lerneinheit NICHT belegen. | 1 KP | 3R | R. Platt | |
Kurzbeschreibung | |||||
Lernziel | |||||
Inhalt | PCR, restriction digest, ligation, transformation, gel analysis, Sanger sequencing, Gibson assembly |