Randall Platt: Catalogue data in Spring Semester 2018

Award: The Golden Owl
Name Prof. Dr. Randall Platt
FieldBiological Engineering
Address
Professur Biologisches Engineering
ETH Zürich, D-BSSE, BSA M 754
Mattenstrasse 26
4058 Basel
SWITZERLAND
Telephone+41 61 387 33 50
E-mailrandall.platt@bsse.ethz.ch
DepartmentBiosystems Science and Engineering
RelationshipAssociate Professor

NumberTitleECTSHoursLecturers
636-0113-00LGenome Engineering4 credits3VR. Platt
AbstractThis course is an introduction to genome engineering and an examination of recent advancements and future challenges. It covers the discovery and development of gene editing technologies and their applications in basic and applied research. The focus is on gaining an in-depth molecular and cellular understanding of the technologies and also insight into how these tools can be used and further deve
ObjectiveThe objective of this course is to learn how gene editing technologies function at the molecular and cellular level, and how they are leveraged to understand the role of genetic elements in biological processes. Students will be introduced to the history and motivation behind the discovery and development of transformative genome engineering technologies, and also gain insight into the ethical, safety, and regulatory facets shaping the field.
ContentThe course content is comprised of lectures, discussions of important literature in the field, and a project. Lectures in Genome Engineering will be technology-focused and incorporate: 1) historical context to motivate the need for developing the technology, 2) development of the technology from concept to robust tool, 3) methods to discover, characterize, and evaluate the technology, and 4) applications of the technology in basic and applied research. Discussions of important literature in the field will be conducted in class, one course meeting following a lecture covering the topic material and assignment of the reading. The project will be team-based and entail devising a solution to a critical need in the field.

Main topics:
--Discovery and development of genome editing technologies
--The prokaryotic adaptive immune system CRISPR-Cas
--Genome engineering methods for generating genetically engineered model systems
--Genotype-phenotype linkage via genetic screens
--Massively paralleled perturbation and phenotyping
--Gene editing tools as genetic recording devices
--Gene editing tools as diagnostics and therapeutics
--Ethics, safety, and regulatory facets of genome engineering
Lecture notesHandout during the course.
LiteraturePeer-reviewed scientific publications will be assigned to complement lecture content.
636-0301-00LCurrent Topics in Biosystems Science and Engineering2 credits1ST. Stadler, N. Beerenwinkel, Y. Benenson, K. M. Borgwardt, P. S. Dittrich, M. Fussenegger, A. Hierlemann, D. Iber, M. H. Khammash, D. J. Müller, S. Panke, R. Paro, R. Platt, S. Reddy, T. Schroeder, J. Stelling
AbstractThis seminar will feature invited lectures about recent advances and developments in systems biology, including topics from biology, bioengineering, and computational biology.
ObjectiveTo provide an overview of current systems biology research.
ContentThe final list of topics will be available at http://www.bsse.ethz.ch/education/.
636-1004-AALBio IV: Genetics
Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement.

Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit.
5 credits7RR. Platt
Abstract
Objective
LiteratureLewin, Genes XI, chapters: 3,15, 16, 19-23, 26-30
636-1008-AALBio Lab III: Molecular Biology I
Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement.

Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit.
1 credit3RR. Platt
Abstract
Objective
ContentPCR, restriction digest, ligation, transformation, gel analysis, Sanger sequencing, Gibson assembly