Paolo Arosio: Catalogue data in Autumn Semester 2019

Name Prof. Dr. Paolo Arosio
FieldBiochemical Engineering
Address
Professur Bioingenieurwissenschaft
ETH Zürich, HCI F 129
Vladimir-Prelog-Weg 1-5/10
8093 Zürich
SWITZERLAND
Telephone+41 44 633 94 40
E-mailpaolo.arosio@chem.ethz.ch
DepartmentChemistry and Applied Biosciences
RelationshipAssociate Professor

NumberTitleECTSHoursLecturers
529-0615-00LBiochemical and Polymer Reaction Engineering
Only for Chemical and Bioengineering MSc, Programme Regulations 2005.

IMPORTANT NOTICE for Chemical and Bioengineering students: There are two different version of this course for the two regulations (2005/2018), please make sure to register for the correct version according to the regulations you are enrolled in.
7 credits3GP. Arosio
AbstractPolymerization reactions and processes. Homogeneous and heterogeneous (emulsion) kinetics of free radical polymerization. Post treatment of polymer colloids. Bioprocesses for the production of molecules and therapeutic proteins. Kinetics and design of aggregation processes of macromolecules and proteins.
ObjectiveThe aim of the course is to learn how to design polymerization reactors and bioreactors to produce polymers and proteins with the specific product qualities that are required by different applications in chemical, pharmaceutical and food industry. This activity includes the post-treatment of polymer latexes, the downstream processing of proteins and the analysis of their colloidal behavior.
ContentWe will cover the fundamental processes and the operation units involved in the production of polymeric materials and proteins. In particular, the following topics are discussed: Overview on the different polymerization processes. Kinetics of free-radical polymerization and use of population balance models. Production of polymers with controlled characteristics in terms of molecular weight distribution. Kinetics and control of emulsion polymerization. Surfactants and colloidal stability. Aggregation kinetics and aggregate structure in conditions of diffusion and reaction limited aggregation. Modeling and design of colloid aggregation processes. Physico-chemical characterization of proteins and description of enzymatic reactions. Operation units in bioprocessing: upstream, reactor design and downstream. Industrial production of therapeutic proteins. Characterization and engineering of protein aggregation. Protein aggregation in biology and in biotechnology as functional materials.
Lecture notesScripts are available on the web page of the Arosio-group: http://www.arosiogroup.ethz.ch/education.html
Additional handout of slides will be provided during the lectures.
LiteratureR.J. Hunter, Foundations of Colloid Science, Oxford University Press, 2nd edition, 2001
D. Ramkrishna, Population Balances, Academic Press, 2000
H.W. Blanch, D. S. Clark, Biochemical Engineering, CRC Press, 1995
529-0615-01LBiochemical and Polymer Reaction Engineering
IMPORTANT NOTICE for Chemical and Bioengineering students: There are two different version of this course for the two regulations (2005/2018), please make sure to register for the correct version according to the regulations you are enrolled in. Please do not register for this course if you are enrolled in regulations 2005.
6 credits3GP. Arosio
AbstractPolymerization reactions and processes. Homogeneous and heterogeneous (emulsion) kinetics of free radical polymerization. Post treatment of polymer colloids. Bioprocesses for the production of molecules and therapeutic proteins. Kinetics and design of aggregation processes of macromolecules and proteins.
ObjectiveThe aim of the course is to learn how to design polymerization reactors and bioreactors to produce polymers and proteins with the specific product qualities that are required by different applications in chemical, pharmaceutical and food industry. This activity includes the post-treatment of polymer latexes, the downstream processing of proteins and the analysis of their colloidal behavior.
ContentWe will cover the fundamental processes and the operation units involved in the production of polymeric materials and proteins. In particular, the following topics are discussed: Overview on the different polymerization processes. Kinetics of free-radical polymerization and use of population balance models. Production of polymers with controlled characteristics in terms of molecular weight distribution. Kinetics and control of emulsion polymerization. Surfactants and colloidal stability. Aggregation kinetics and aggregate structure in conditions of diffusion and reaction limited aggregation. Modeling and design of colloid aggregation processes. Physico-chemical characterization of proteins and description of enzymatic reactions. Operation units in bioprocessing: upstream, reactor design and downstream. Industrial production of therapeutic proteins. Characterization and engineering of protein aggregation. Protein aggregation in biology and in biotechnology as functional materials.
Lecture notesScripts are available on the web page of the Arosio-group: http://www.arosiogroup.ethz.ch/education.html
Additional handout of slides will be provided during the lectures.
LiteratureR.J. Hunter, Foundations of Colloid Science, Oxford University Press, 2nd edition, 2001
D. Ramkrishna, Population Balances, Academic Press, 2000
H.W. Blanch, D. S. Clark, Biochemical Engineering, CRC Press, 1995
529-0632-00LHomogeneous Reaction Engineering4 credits3GP. Arosio, T. Casalini
AbstractKinetics of homogeneous reactions. Ideal reactors: optimization of conversion and selectivity for complex kinetic networks. Thermal effects in chemical reactors. Residence time distribution. Analysis and design of real reactors. Fast reactions in turbulent flows. Sensitivity and stability of chemical reactors.
ObjectiveProvide to the students a complete methodology for the analysis and design of homogeneous reactors
ContentKinetic models for homogeneous reactions. Collection and analysis of experimental rate data. Isothermal ideal reactors. Complex reaction networks. Reactor design for conversion and selectivity optimization. Adiabatic and non-isothermal reactors. Temperature effect on reversible reactions. Residence time distribution in chemical reactors. Role of mixing in turbolent reacting systems. Design of real reactors. Parametric sensitivity and stability in chemical reactors.
Lecture notesScripts are available on line on the web page of the Morbidelli group.
LiteratureH.S. Fogler, Elements of Chemical Reaction Engineering, Prentice Hall, 3rd edition, 1999
O. Levenspiel, Chemical Reaction Engineering, John Wiley, 3rd edition, 1999
J. Baldyga and J.R. Bourne, Turbulent Mixing and Chemical Reactions, John Wiley, 1999
A. Varma, M. Morbidelli and H. Wu, Parametric Sensitivity in Chemical Systems, Cambridge University Press, 1999
A. Varma and M. Morbidelli, Mathematical Methods in Chemical Engineering, Oxford University Press, 1997
529-0690-00LICB Seminars on Chemical and Biochemical Engineering Information 1 creditP. Arosio
AbstractThe ICB seminar series covers the umbrella of diverse research activities encompassed within the institute, including catalysis, functional materials, polymer engineering, separations, microfluidics, process design, and systems engineering. This series was founded with the aim or promoting cross-disciplinary scientific discourse and interaction with other distinguished groups working worldwide.
ObjectiveStudents are expected to attend all seminars in one academic year, and should register at the beginning of each seminar. Additionally they must deliver a two page written report at the end of the year describing the topics covered, main conclusions, and interrelationships between the different themes.
ContentThe ICB seminar series covers the umbrella of diverse research activities encompassed within the institute, including catalysis, functional materials, polymer engineering, separations, microfluidics, process design, and systems engineering. This series was founded with the aim or promoting cross-disciplinary scientific discourse and interaction with other distinguished groups working worldwide, and is targeted at individuals who have made outstanding contributions within their fields. Each year, around 7 distinguished scientists and technologists will be invited to speak on topics of current interest in Chemical and Biochemical Engineering. PhD students are particularly encouraged to attend in order to broaden their perception and enrich their scientific horizons.