Karsten Weis: Katalogdaten im Herbstsemester 2022 |
| Name | Herr Prof. Dr. Karsten Weis |
| Lehrgebiet | Zelluläre Dynamik |
| Adresse | Institut für Biochemie ETH Zürich, HPM E 6 Otto-Stern-Weg 3 8093 Zürich SWITZERLAND |
| Telefon | +41 44 632 30 08 |
| karsten.weis@bc.biol.ethz.ch | |
| Departement | Biologie |
| Beziehung | Ordentlicher Professor |
| Nummer | Titel | ECTS | Umfang | Dozierende | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 551-0337-00L | Cell Biology of the Nucleus  Number of participants limited to 18. The enrolment is done by the D-BIOL study administration. | 6 KP | 7P | R. Kroschewski, Y. Barral, M. Jagannathan, S. Jessberger, K. Weis | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | Introduction to the organizational principles of the nucleus using budding yeast, drosophila and vertebrate cells as model systems. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | The aim of our course is to introduce the students to the organizational principles of the nucleus using budding yeast, drosophila and vertebrate cells as model systems. Emphasis is given to: • Establishment of nuclear identity and nuclear-cytoplasmic communication • Reorganization of the nucleus in aging • Animal cells during the generation of cell diversity and neuronal differentiation By the end of the course, based on lectures, literature reading and practical lab work, the students will be able to formulate open questions concerning the function of the nucleus. Thus, the students will know about the mechanisms and consequences of nuclear-cytoplasmic compartmentalization, nuclear positioning, DNA clustering in the nucleus and cytoplasm during cell divisions and aging. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | During this block-course, the students will - learn how organelles establish and maintain identity with a focus on the nucleus - discover the evolutionary and functional plasticity of the nucleus - design, apply, evaluate and compare experimental strategies Students - in groups of 2 or max. 3 - will be integrated into a research project connected to the subject of the course, within one of the participating research groups. Lectures and technical notes will be given and informal discussions held to provide you with the theoretical background. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Skript | There will be optional papers to be read before the course start. They serve as framework orientation for the practical parts of this block course and will be made accessible to you shortly before the course starts on the relevant Moodle site. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literatur | Documentation and recommended literature (review articles) will be provided during the course. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 551-0357-00L | Cellular Matters: From Milestones to Open Questions The number of participants is limited to 22 and will only take place with a minimum of 11 participants. Please sign up until two weeks before the beginning of the semester (for Autumn 2022: by 05.09.2022 end of day) via e-mail to bml@ethz.ch using in the subject: 551-0357-00. In the email body indicate 1) your name, 2) your e-mail address, 3) master/PhD program. The students admitted to this seminar will be informed by e-mail in the week prior to the beginning of the semester. The first lecture will serve to form groups of students and assign papers. | 4 KP | 2S | Y. Barral, F. Allain, P. Arosio, E. Dufresne, D. Hilvert, M. Jagannathan, R. Mezzenga, T. Michaels, G. Neurohr, R. Riek, A. E. Smith, K. Weis, H. Wennemers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | In this course, the students will explore the quite new topic of biomolecular condensates. Concepts and tools from biology, chemistry, biophysics and soft materials will be used, on one hand, to develop an understanding of the biological properties and functions of biomolecular condensates in health and disease, while, on the other, to inspire new materials. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | In terms of content, you, the student, after a general introduction to the topic, will learn about milestone works and current research questions in the young field of biomolecular condensates (properties, functions and applications) from an interdisciplinary point of view in a course which is a combination of literature (presentations given by pairs of students with different scientific backgrounds) and research seminars (presentations given by the lecturers all active experts in the field, with different backgrounds and expertise). As to the skills, you will have the opportunity to learn how to critically read and evaluate scientific literature, how to give scientific presentations to an interdisciplinary audience (each presentation consisting of an introduction, critical description of the results and discussion of their significance) and substantiate your statements, acquire a critical mindset (pros/cons of chosen approaches/methods and limitations, quality of the data, solidity of the conclusions, possible follow-up experiments) that allows you to ask relevant questions and actively participate to the discussion. With the final presentation you will have the unique opportunity to interact closely with the interdisciplinary group of lecturers (all internationally well-established experts) who will guide you in the choice of a subtopic and related literature. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | In the last decade a new kind of compartments within the cell, the so-called biomolecular condensates, have been observed. This discovery is radically changing our understanding of the cell, its organization and dynamics. The emerging picture is that the cytoplasm and nucleoplasm are highly complex fluids that can (meta)stably segregate into membrane-less sub-compartments, similarly to emulsions. The topic of biomolecular condensates goes beyond the boundaries of traditional disciplines and needs a multi-pronged approach that levers on, and cross-fertilizes, biology, physical chemistry, biophysics and soft materials to develop a proper understanding of the properties, functions in health and disease (Alzheimer’s, Parkinson’s, etc.), as well as possible applications of these biomolecular condensates. Each week the lecture will consist of: 1) a short literature seminar: Pairs of students from different scientific backgrounds will be formed and assigned beforehand to present milestone literature to the class and facilitate the ensuing discussion. In the first class the pairs will be formed, the milestone papers made known to the whole class and assigned to the pairs. 2) a research seminar: the presentation of the milestone literature will serve as the introduction to the lecture by one of the lecturers of the course on their own state-of-the-art research in the field. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Skript | The presentations will be made available after the lectures. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literatur | The milestone papers will be provided in advance. For the final examination, the students will be helped by the lecturers in identifying a research topic and related literature. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Kompetenzen |
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| 551-1005-00L | Bioanalytics | 4 KP | 4G | P. Picotti, F. Allain, V. Korkhov, M. Pilhofer, R. Schlapbach, K. Weis, K. Wüthrich, weitere Dozierende | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | Der Kurs gibt eine Einführung in die wichtigsten der modernen biologischen Forschung zugrunde liegenden Labortechniken. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | Für jede der besprochenen Techniken können die Studierenden am Ende des Kurses erklären: a) die physikalischen, chemischen und biologischen Prinzipien die der Technik zugrunde liegen, b) welche Anforderungen Technik an die verwendeten Proben stellt c) welche Rohdaten erhoben werden d) welche Annahmen und Zusatzdaten bei der Interpretation der Daten verwendet werden. e) wie die Daten und die Resultate der Analyse benutzt werden um biologische Fragen zu beantworten. Am Ende des Kurses werden die Studierenden in der Lage sein unter den besprochenen Techniken diejenigen auszuwählen, die am besten geeignet sind um eine bestimmte biologische Frage zu beantworten. Sie werden zusätzlich in der Lage sein die Vor- und Nachteile der in Frage kommenden Techniken zu diskutieren und zu beschreiben wie verschiedene Techniken kombiniert werden können um ein umfassenderes Verständnis der biologische Frage zu erhalten. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | Der Kurs wird aus einer Kombination von Vorlesungen, Selbststudiumseinheiten und Übungen bestehen. Der Fokus des Kurses liegt auf folgenden Techniken: -DNA Sequenzierung - Chromatographische Techniken - Massenspektrometrie - UV/Vis- und Fluoreszensspektroskopie - Lichtmikroskopie - Elektronenmikroskopie - Röntgenkristallographie - NMR Spektroskopie | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Skript | Der Kurs wird durch eine Moodle Seite unterstützt auf der für den Kurs notwendigen Materialen zur Verfügung gestellt werden. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kompetenzen |
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| 551-1303-00L | Cellular Biochemistry of Health and Disease Number of participants limited to 20. | 4 KP | 2S | V. Korkhov, T. Ishikawa, M. Jagannathan, R. Kroschewski, G. Neurohr, M. Peter, A. E. Smith, B. Snijder, K. Weis | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | During this Masters level seminar style course, students will explore current research topics in cellular biochemistry focused on the structure, function and regulation of selected cell components, and the consequences of dysregulation for pathologies. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | Students will work with experts toward a critical analysis of cutting-edge research in the domain of cellular biochemistry, with emphasis on normal cellular processes and the consequences of their dysregulation. At the end of the course, students will be able to introduce, present, evaluate, critically discuss and write about recent scientific articles in the research area of cellular biochemistry. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | Guided by an expert in the field, students will engage in classical round-table style discussions of current literature with occasional frontal presentations. Students will alternate as discussion leaders throughout the semester, with the student leader responsible to briefly summarize key general knowledge and context of the assigned primary research paper. Together with the faculty expert, all students will participate in discussion of the primary paper, including the foundation of the biological question, specific questions addressed, key methods, key results, remaining gaps and research implications. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literatur | The literature will be provided during the course | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | The course will be taught in English. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||