Karsten Weis: Katalogdaten im Herbstsemester 2017 |
| Name | Herr Prof. Dr. Karsten Weis |
| Lehrgebiet | Zelluläre Dynamik |
| Adresse | Institut für Biochemie ETH Zürich, HPM E 6 Otto-Stern-Weg 3 8093 Zürich SWITZERLAND |
| Telefon | +41 44 632 30 08 |
| karsten.weis@bc.biol.ethz.ch | |
| Departement | Biologie |
| Beziehung | Ordentlicher Professor |
| Nummer | Titel | ECTS | Umfang | Dozierende | |
|---|---|---|---|---|---|
| 551-0336-00L | Methods in Cellular Biochemistry   Number of participants limited to 18. The enrolment is done by the D-BIOL study administration. | 6 KP | 7G | P. Picotti, J. Fernandes de Matos, U. Kutay, M. Peter, K. Weis | |
| Kurzbeschreibung | Students will learn about biochemical approaches to analyze cellular functions. The course consists of practical projects in small groups, lectures and literature discussions. The course concludes with the presentation of results at a poster session. | ||||
| Lernziel | Students will learn to design, carry out and assess experiments using current biochemical and cell biological strategies to analyze cellular functions in a wide range of model systems. In particular they will learn novel imaging techniques along with biochemical approaches to understand fundamental cellular pathways. Furthermore, they will learn to assess strengths and limitations of the different approaches and be able to discuss their validity for the analysis of cellular functions. | ||||
| Literatur | Documentation and recommended literature (review articles and selected primary literature) will be provided during the course. | ||||
| Voraussetzungen / Besonderes | This course will be taught in English. | ||||
| 551-1003-00L | Methoden der Biologischen Analytik | 3 KP | 3G | R. Aebersold, M. Badertscher, K. Weis | |
| Kurzbeschreibung | 529-1042-00 Grundlagen der wichtigsten Trennmethoden und der Interpretation von Molekülspektren. 551-1003-00 Der Kurs befasst sich mit den Methoden und ausgewählten Anwendungen von Methoden der Nukleinsäuresequenzierung, der massenspektrometrischen Analyse von Proteinen und Proteomen und Licht-und Fluoreszenz gestützten Methoden der Mikroskopie. | ||||
| Lernziel | 529-1042-00 Kenntnis der notwendigen Grundlagen und der Anwendungsmöglichkeiten für den Einsatz von relevanten spektroskopischen und Trennmethoden in der analytisch-chemischen Praxis. 551-1003-00 Kenntnis der notwendigen Grundlagen und der Anwendungsmöglichkeiten der Methoden für die Bestimmung von Nukleinsäuresequenzen, der massenspektrometrischen Analyse von Proteinen und Proteomen und Licht-und Fluoreszenz gestützten Methoden der Mikroskopie. | ||||
| Inhalt | 529-1042-00 Anwendungsorientierte Grundlagen der organischen Instrumentalanalytik und des empirischen Einsatzes von Methoden der Strukturaufklärung (Massenspektrometrie, NMR-, IR-, UV/VIS-Spektroskopie). Grundlagen und Anwendung chromatographischer und elektrophoretischer Trennverfahren. Praxisnahe Anwendung und Vertiefung des Grundwissens anhand von Übungen. 551-1003-00 Der Kurs setzt sich zusammen aus Vorlesungen, die die theoretischen und technischen Grundlagen der betreffenden analytischen Methoden vermitteln und Übungen, die sich mit den Anwendungen der analytischen Methoden in der modernen experimentellen Biologie befassen. | ||||
| Skript | 529-1042-00 Ein umfangreiches Skript ist im HCI-Shop erhältlich. Eine Kurzfassung des Teils "Spektroskopie" definiert die für die Prüfung dieses Teils relevanten Themen. | ||||
| Literatur | 529-1042-00 - Pretsch E., Bühlmann P., Badertscher M. Structure Determination of Organic Compounds, 5th revised and enlarged English edition, Springer-Verlag, Berlin 2009; - Pretsch E., Bühlmann P., Badertscher M., Spektroskopische Daten zur Strukturaufklärung organischer Verbindungen, fünfte Auflage, Springer-Verlag, Berlin 2010; - D.A. Skoog, J.J. Leary, Instrumentelle Analytik, Grundlagen, Geräte, Anwendungen, Springer, Berlin, 1996; - K. Cammann, Instrumentelle Analytische Chemie, Verfahren, Anwendungen, Qualitätssicherung, Spektrum Akademischer Verlag, Heidelberg, 2001; - R. Kellner, J.-M. Mermet, M. Otto, H.M. Widmer, Analytical Chemistry, Wiley-VCH Verlag, Weinheim, 1998; - K. Robards, P.R.Haddad, P.E. Jackson, Principles and practice of modern chromatographic methods, Academic Press, London, 1994; | ||||
| Voraussetzungen / Besonderes | 529-1042-00 Voraussetzungen: - 529-1001-01 V "Allgemeine Chemie I (für Biol./Pharm.Wiss.)" - 529-1001-00 P "Allgemeine Chemie I (für Biol./Pharm.Wiss.)" - 529-1011-00 G "Organische Chemie I (für Biol./Pharm.Wiss.)" | ||||
| 551-1303-00L | Cellular Biochemistry of Health and Disease Number of participants limited to 20. | 4 KP | 2S | P. Picotti, Y. Barral, J. Fernandes de Matos, V. Korkhov, B. Kornmann, R. Kroschewski, M. Peter, A. E. Smith, K. Weis | |
| Kurzbeschreibung | During this Masters level seminar style course, students will explore current research topics in cellular biochemistry focused on the structure, function and regulation of selected cell components, and the consequences of dysregulation for pathologies. | ||||
| Lernziel | Students will work with experts toward a critical analysis of cutting-edge research in the domain of cellular biochemistry, with emphasis on normal cellular processes and the consequences of their dysregulation. At the end of the course, students will be able to introduce, present, evaluate, critically discuss and write about recent scientific articles in the research area of cellular biochemistry. | ||||
| Inhalt | Guided by an expert in the field, students will engage in classical round-table style discussions of current literature with occasional frontal presentations. Students will alternate as discussion leaders throughout the semester, with the student leader responsible to briefly summarize key general knowledge and context of the assigned primary research paper. Together with the faculty expert, all students will participate in discussion of the primary paper, including the foundation of the biological question, specific questions addressed, key methods, key results, remaining gaps and research implications. | ||||
| Literatur | The literature will be provided during the course | ||||
| Voraussetzungen / Besonderes | The course will be taught in English. | ||||
| 551-1309-00L | RNA-Biology Number of participants limited to 20. The enrolment is done by the D-BIOL study administration. | 6 KP | 7G | B. Mateescu, F. Allain, C. Beyer, J. Hall, R. Santoro, O. Voinnet, K. Weis, A. Wutz | |
| Kurzbeschreibung | Introduction to the diversity of current RNA-research at all levels from structural biology to systems biology using mainly model systems like S. cerevisiae (yeast), mammalian cells. | ||||
| Lernziel | The students will obtain an overview about the diversity of current RNA-research. They will learn to design experiments and use techniques necessary to analyze different aspects of RNA biology. Through lectures and literature seminars, they will learn about the burning questions of RNA research and discuss approaches to address these questions experimentally. In practical lab projects the students will work in one of the participating laboratories. Finally, they will learn how to present and discuss their data in an appropriate manner. Student assessment is a graded semester performance based on individual performance in the laboratory, the written exam and the poster presentation. | ||||
| Literatur | Documentation and recommended literature will be provided at the beginning and during the course. | ||||
| Voraussetzungen / Besonderes | The course will be taught in English. | ||||