Jan Alexander Hiss: Catalogue data in Autumn Semester 2020

Name Dr. Jan Alexander Hiss
Address
Inst. f. Pharmazeutische Wiss.
ETH Zürich, HCI G 492.5
Vladimir-Prelog-Weg 1-5/10
8093 Zürich
SWITZERLAND
Telephone+41 44 633 73 75
Fax+41 44 633 13 79
E-mailjan.hiss@pharma.ethz.ch
URLhttp://www.cadd.ethz.ch
DepartmentChemistry and Applied Biosciences
RelationshipLecturer

NumberTitleECTSHoursLecturers
511-0007-00LScientific Writing and Presenting Restricted registration - show details
Only for Pharmaceutical Sciences MSc.
2 credits2GG. Schneider, J. Dolenc, J. A. Hiss, J.‑C. Leroux, O. Renn
AbstractThis introductory class provides an overview of the basic scientific writing techniques and a guideline to presenting scientific data, together with guided exercises and hands-on training. It is devised to accompany the research projects within the curriculum of the MSc in Pharmaceutical Sciences.
ObjectiveThe class enables the participants to prepare their own scientific texts and oral presentations, and critically assess the quality of the presentation of scientific data.
ContentThe participants receive an introduction to basic formal aspects of scientific writing and the design of graphical elements. Lectures and topical seminars alternate with practical task for the participants, which will be evaluated in a peer-to-peer setting. Performance feedback is provided by both the teachers and the peers.
535-0022-00LComputer-Assisted Drug Design Restricted registration - show details 1 credit1VG. Schneider, F. Grisoni, J. A. Hiss
AbstractThe lecture series provides an introduction to computer applications in medicinal chemistry. A focus is on molecular representations, property predictions, molecular similarity concepts, virtual screening techniques, and de novo drug design. All theoretical concepts and algorithms presented are illustrated by practical applications and case studies
ObjectiveThe students will learn how computer simulation generates ideas for drug design and development, understand the theoretical principles of property prediction and computer-generated compound generation, and understand possibilities and limitations of computer-assisted drug design in pharmaceutical chemistry. As a result, they are prepared for professional assessment of computer-assisted drug design studies in medicinal chemistry projects.
LiteratureRecommended textbooks:
1) G. Schneider, K.-H. Baringhaus (2008) "Molecular Design - Concepts and Applications", Wiley-VCH: Weinheim, New York.
2) H.-D. Höltje, W. Sippl, D. Rognan, G. Folkers (2008) "Molecular Modeling: Basic Principles and Applications", Wiley-VCH: Weinheim, New York.
3) G. Klebe (2009) "Wirkstoffdesign", Spektrum Akademischer Verlag: Heidelberg.
Prerequisites / NoticeSuccessful participation in this course is required for a research project ("Forschungspraktikum") in the CADD group.
535-0023-00LComputer-Assisted Drug Design (Practical Course) Restricted registration - show details 4 credits6PG. Schneider, J. A. Hiss
AbstractThe practical course is open for master and graduate students to get an introduction into hands-on computer-assisted drug design. The class includes an introduction to computer-based screening of a virtual compound library, subsequent synthesis of candidate ligands, and biochemically testing for activity on pharmacologically important drug targets.
ObjectiveParticipants become familiar with state-of-the-art methodologies in a real-life computer-aided medicinal chemistry project. Participants work as small teams, perform literature research and discuss recent research findings. A seminar talk is to be given presenting the molecular design strategy chosen and the results obtained during the course.
ContentThe course offers the possibility for people with and without computational and or laboratory background to get an introduction into computer-assisted drug design, as well as practical training in a modern chemical laboratory. Using various software suites, the participants will computationally create and screen a virtual compound library for potential active small molecules. The process will involve an introduction to screening a virtual compound library, synthesizing candidate inhibitors, and biophysical testing against a pharmacologically important drug target.
Lecture notesDetailed information will be handed out during the course.
LiteratureTextbook:
Schneider, G. and Baringhaus, K.-H. (2008) Molecular Design - Concepts and Applications. Wiley-VCH, Weinheim, New York.
Prerequisites / NoticeThe class is organized as a two-week block course.
The number of participants is limited. To enroll in the course, please consult the lecturer.

Kick-off meeting and confirmation of registration (Vorbesprechung und Platzvergabe): During the last lecture of the class "Computer-Assisted Drug Design" (535-0022-00)

Ideally, students interested in the course participated and successfully passed the lecture "Computer-Assisted Drug Design" (535-0022-00).