Jörn Piel: Catalogue data in Autumn Semester 2018
|Prof. Dr. Jörn Piel
Institut für Mikrobiologie
ETH Zürich, HCI G 431
|+41 44 633 07 55
|Microbiology (Part I)
|W.‑D. Hardt, L. Eberl, H.‑M. Fischer, J. Piel, M. Pilhofer
|Advanced lecture class providing a broad overview on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.
|This concept class will be based on common concepts and introduce to the enormous diversity among bacteria and archaea. It will cover the current research on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.
|Advanced class covering the state of the research in bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.
|Updated handouts will be provided during the class.
|Current literature references will be provided during the lectures.
|Prerequisites / Notice
The lecture "Grundlagen der Biologie II: Mikrobiologie" is the basis for this advanced lecture.
|J. Vorholt-Zambelli, J. Piel
|The lecture course aims at providing an advanced understanding of the physiology and metabolism of microorganisms. Emphasis is on processes that are specific to bacteria and archaea and that contribute to the widespread occurrence of prokaryotes. Applied aspects of microbial biochemistry will be pointed out as well as research fields of current scientific interest.
|The lecture course aims at providing an advanced understanding of the physiology and metabolism of microorganisms.
|Important biochemical processes specific to bacteria and archaea will be presented that contribute to the widespread occurrence of prokaryotes. Applied aspects of microbial biochemistry will be pointed out as well as research fields of current scientific interest. Emphasis is on concepts of energy generation and assimilation.
List of topics:
Eating sugars and letting them in
Challenging: Aromatics, xenobiotics, and oil
Complex: (Ligno-)Cellulose and in demand for bioenergy
Living on a diet and the anaplerotic provocation
Of climate relevance: The microbial C1 cycle
What are AMO and Anammox?
20 amino acids: the making of
Extending the genetic code
The 21st and 22nd amino acid
Some exotic biochemistry: nucleotides, cofactors
Ancient biochemistry? Iron-sulfur clusters, polymers
Secondary metabolites: playground of evolution
|A script will be provided during the course.
|Progress Reports in Microbiology and Immunology
Students must sign up via secr.micro.biol.ethz.ch
|J. Piel, M. Aebi, H.‑M. Fischer, W.‑D. Hardt, A. Oxenius, J. Vorholt-Zambelli
|Presentation and discussion of current research results in the field of Microbiology and Infection Immunology
|Precise and transparent presentation of research findings in relation to the current literature, critical discussion of experimental data and their interpretation, development and presentation of future research aims
|Seminars in Microbiology
|M. Aebi, H.‑M. Fischer, W.‑D. Hardt, M. Künzler, J. Piel, S. Sunagawa, J. Vorholt-Zambelli
|Seminars by invited speakers covering selected microbiology themes.
|Discussion of selected microbiology themes presented by invited speakers.
|Bioactive Natural Products from Bacteria
Number of participants limited to 8.
The enrolment is done by the D-BIOL study administration.
|Lab course. In small groups projects of relevance to current research questions in the field of bacterial natural product biosynthesis are addressed.
|Introduction to relevant subjects of the secondary metabolism of bacteria. Training in practical work in a research laboratory. Scientific writing in form of a research report.
|Research project on bacteria that produce bioactive natural products (e.g., Streptomycetes, Cyanobacteria, uncultivated bacteria). The techniques used will depend on the project, e.g. PCR, cloning, natural product analysis, precursor feeding studies, enzyme expression and analysis.
|Will be provided for each of the projects at the beginning of the course.