Anton Wutz: Catalogue data in Autumn Semester 2023 |
| Name | Prof. Dr. Anton Wutz |
| Field | Genetics |
| Address | Inst. f. Molecular Health Sciences ETH Zürich, HPL E 12 Otto-Stern-Weg 7 8093 Zürich SWITZERLAND |
| Telephone | +41 44 633 08 48 |
| awutz@ethz.ch | |
| Department | Biology |
| Relationship | Full Professor |
| Number | Title | ECTS | Hours | Lecturers | ||||||||||||||||||||||||||||||||||||||||||||
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| 551-0127-00L | Fundamentals of Biology III: Multicellularity | 8 credits | 6G | M. Stoffel, M. Künzler, O. Y. Martin, U. Suter, S. Werner, A. Wutz, S. C. Zeeman | ||||||||||||||||||||||||||||||||||||||||||||
| Abstract | The lecture conveys the fundamental concepts underlying multicellularity with an emphasis on the molecular basis of multicellular biological systems and their functional integration into coherent wholes. The structural and functional specialization in multicellular organisms will be discussed by highlighting common and specific functions in fungi, plants, and animals (including humans). | |||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | 1.Students can describe advantages and challenges associated with being multicellular and outline independent solutions that organisms have developed to cope with the challenges of complex multicellularity . 2.Students can explain how the internal and external structures of fungi, plants and animals function to support survival, growth, behavior, and reproduction. 3.Students can explain the basic pathways and mechanisms of cellular communication regulating cellular behavior (cell adhesion, metabolism, proliferation, reproduction, development). 4.Students can describe how a single cell develops from one cell into many, each with different specialized functions. | |||||||||||||||||||||||||||||||||||||||||||||||
| Content | The lecture introduces the structural and functional specialization in fungi, plants and animals, including humans. After providing an overview on the diversity of eukaryotic organisms, the lecture will discuss how fungi, plants, animals and humans have evolved structures and strategies to cope with the challenges of multicellularity. The molecular basis underlying communication, coordination and differentiation will be conveyed and complemented by key aspects of reproduction, metabolism development, and regeneration. Topics include form and function of fungi and plants, human anatomy and physiology, metabolism, cell signaling, adhesion, stem cells, regeneration, reproduction, and development. | |||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Alberts et al. 'Molecular Biology of the Cell' 6th edition Smith A.M., et al. “Plant Biology” Garland Science, New York, Oxford Campbell “Biology”, 11th Edition | |||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Some lecture are held in English. | |||||||||||||||||||||||||||||||||||||||||||||||
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| 551-1201-00L | Computational Methods in Genome and Sequence Analysis  Number of participants limited to 7. The enrolment is done by the D-BIOL study administration. | 6 credits | 7P | A. Wutz | ||||||||||||||||||||||||||||||||||||||||||||
| Abstract | This course aims to provide students with a comprehensive overview of computational methods for sequence analysis and assist with developing skills for application of computational approaches by experimental scientists in the life sciences. | |||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Methods for analyzing animal genomes are increasingly becoming important for applications in human health and biotechnology suggesting that the experience will be useful to develop relevant expertise for a broad range of functions. Students will have the opportunity to advance their knowledge in programming by focusing on algorithms for genome and gene sequence analysis. A major goal of the course will be to lead the student to an independent and empowered attitude towards computational problems. For reaching this goal the students will work on an implementation of a solution for a set real-world problem in genome and sequence analysis under guided supervision. | |||||||||||||||||||||||||||||||||||||||||||||||
| Content | •Understanding the information in biological sequences and quantifying similarity •Introduction to algorithms for sequence comparison and searches •Implementation of sequence comparisons and searches in Python •Accessing data formats associated with genome sequence analysis tasks •Understanding the anatomy of a real world sequence analysis project •Applying tools for sequence alignment and estimating error rates •Ability to implement a solution to a problem in sequence analysis using Python •Accessing genome annotation and retrieving relevant information in Pandas •Application of Genomic intervals and arrays for sequence analysis with HTSeq The course will consist of a series of lectures, assignments for implementing elementary tasks in Python, project development and discussion workshops, and 3 and a half week of practical work implementing a Pythons script as a solution to a real world problem associated with sequence analysis. At the end of the course students will explain their solutions and demonstrate the functionality of their implementations, which will then be discussed and commented on by the group. It is expected that students will be able to apply the knowledge to improve on concrete problems. | |||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | - It is recommended to bring your own computer with a Python installation to the course - simple computers can be provided - Programming basics with Python | |||||||||||||||||||||||||||||||||||||||||||||||
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| 551-1709-00L | Genomic and Genetic Methods in Cell and Developmental Biology Number of participants limited to 8. The enrolment is done by the D-BIOL study administration. | 6 credits | 7P | A. Wutz, M. Kopf, T. Schroeder | ||||||||||||||||||||||||||||||||||||||||||||
| Abstract | This course aims to provide students with a comprehensive overview of mammalian developmental biology and stem cell systems both on the theoretical as well as the experimental level. Centering the course on genetic and genomic methods engages the students in contemporary research and prepares for future studies in the course of semester and master projects. | |||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | - Understanding mammalian development - Introduction to stem cells systems - Working with cultured cells - Translational aspects of mammalian cell biology | |||||||||||||||||||||||||||||||||||||||||||||||
| Content | The course will consist of a series of lectures, assay assignments, project development and discussion workshops, and 2 and a half week of lab work with different mammalian cell systems embedded in real life research projects. At the end of the course students will take an exam consisting of questions on the topic of the lectures and workshops. It is expected that students will be able to apply the knowledge to concrete problems. | |||||||||||||||||||||||||||||||||||||||||||||||
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