|Name||Prof. Dr. Sai Reddy|
|Field||Systems and Synthetic Immunology|
Systems and Synthetic Immunology
ETH Zürich, D-BSSE, BSD H 324
|Telephone||+41 61 387 33 68|
|Department||Biosystems Science and Engineering|
Attention: This course was offered in previous semesters with the number: 636-0010-00L "Biomolecular Engineering and Immunotechnology". Students that already passed course 636-0010-00L cannot receive credits for course 636-0110-00L.
|4 credits||3V||S. Reddy|
|Abstract||Immunoengineering is an emerging area of research that uses technology and engineering principles to understand and manipulate the immune system. This is a highly interdisciplinary field and thus the instructor will present an integrated view that will include basic immunology, systems immunology, and synthetic immunology.|
|Objective||The objective of this course is to introduce the students to the basic principles and applications of Immunoengineering. There will be an emphasis directed towards applications directly relevant in immunotherapy and biotechnology. This course requires prerequisite knowledge of molecular biology, biochemistry, cell biology, and genetics; these subjects will only be reviewed briefly during the course.|
|Content||Immunoengineering will be divided into three primary sections: i) basic principles in immunology; ii) systems immunology; iii) synthetic immunology. |
I. Basic principles in immunology will cover the foundational concepts of innate and adaptive immunity. Topics include immunogenetics, pattern recognition receptors, lymphocyte receptors, humoral and T cell responses.
II. Systems immunology uses quantitative multiscale measurements and computational biology to describe and understand the complexity of the immune system. In this section we will cover high-throughput methods that are used to understand and profile immune responses.
III. Synthetic immunology is based on using methods in molecular and cellular engineering to control immune cell function and behavior. In this section students will learn about how immune receptors and cells are being engineered for applications such as cancer immunotherapy and precision and personalized medicine.
|Literature||Reading material from Janeway's Immunobiology will be distributed, so students do not need to worry about purchasing or obtaining it. Supporting reading material from research articles will be provided to students.|
|Prerequisites / Notice||This course requires prerequisite knowledge of molecular biology, biochemistry, cell biology, and genetics; these subjects will only be reviewed briefly during the course.|
|636-0301-00L||Current Topics in Biosystems Science and Engineering||2 credits||1S||T. Stadler, N. Beerenwinkel, Y. Benenson, K. M. Borgwardt, P. S. Dittrich, M. Fussenegger, A. Hierlemann, D. Iber, M. H. Khammash, D. J. Müller, S. Panke, R. Paro, R. Platt, S. Reddy, T. Schroeder, J. Stelling|
|Abstract||This seminar will feature invited lectures about recent advances and developments in systems biology, including topics from biology, bioengineering, and computational biology.|
|Objective||To provide an overview of current systems biology research.|
|Content||The final list of topics will be available at http://www.bsse.ethz.ch/education/.|
|636-1007-AAL||Bio Lab II: Microbiology|
Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement.
Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit.
|1 credit||3R||S. Reddy|
|Content||E. coli cultures, growth curves in different formats (shake flasks, µTPs) and readouts, making competent cells, transformation and electroporation, plasmid isolation, ELISA|