Jens Möller: Catalogue data in Spring Semester 2018 |
| Name | Dr. Jens Möller |
| Department | Health Sciences and Technology |
| Relationship | Lecturer |
| Number | Title | ECTS | Hours | Lecturers | |
|---|---|---|---|---|---|
| 376-1611-00L | Biomedical Interfaces  | 4 credits | 2V + 1U | J. Möller, R. Konradi, V. Vogel | |
| Abstract | This class serves as an introduction into the design of materials for biomedical applications. Its focus lies on controlling interactions at the interface between biomolecules or living cells and synthetic materials. Knowing some basic concepts allows us to define prototypical requirements for material surfaces and to utilize molecular engineering principles for their realization. | ||||
| Learning objective | 1. The students will know basic rules that determine the interaction of biological molecules or cells with synthetic materials on the nanoscale. 2. The students will be able to define essential requirements how to functionalize materials in the context of specific biomedical applications. 3. The students will be able to predict the outcome of self-assembly processes and utilize these to achieve a desired function or biological behavior at interfaces. | ||||
| Content | - protein-surface interactions - anti-adhesive surface coatings - biosensors - bacteria-surface interactions - cell-nanoparticle interactions - drug delivery systems - cell-matrix interactions - soft tissue engineering | ||||
| Lecture notes | Handouts of the lecture can be accessed online. | ||||
| Literature | Selected chapters of - Biomaterials Science: an Introduction to Materials in Medicine, by B. Ratner, 3rd Ed. Academic Press (2013). - Biomimetic Materials and Design: Biointerfacial Strategies, Tissue Engineering and Targeted Drug Delivery, by A.K. Dillow and A.M. Lowman, CRC Press (2002). - Biomaterials: Principles and Practices, by J.Y. Wong et al., CRC Press (2013). - Molecular Biology of the Cell, by B. Alberts et al., Taylor & Francis, 5th Ed. (2007). Detailed literature references will be provided in the lectures. | ||||
| Prerequisites / Notice | This interdisciplinary class addresses students from all disciplines at the Bachelor level. We premise a profound basic knowledge of cell biology and biochemistry. | ||||
| 376-1614-00L | Principles in Tissue Engineering | 3 credits | 2V | K. Maniura, J. Möller, M. Zenobi-Wong | |
| Abstract | Fundamentals in blood coagulation; thrombosis, blood rheology, immune system, inflammation, foreign body reaction on the molecular level and the entire body are discussed. Applications of biomaterials for tissue engineering in different tissues are introduced. Fundamentals in medical implantology, in situ drug release, cell transplantation and stem cell biology are discussed. | ||||
| Learning objective | Understanding of molecular aspects for the application of biodegradable and biocompatible Materials. Fundamentals of tissue reactions (eg. immune responses) against implants and possible clinical consequences will be discussed. | ||||
| Content | This class continues with applications of biomaterials and devices introduced in Biocompatible Materials I. Fundamentals in blood coagulation; thrombosis, blood rheology; immune system, inflammation, foreign body reaction on the level of the entire body and on the molecular level are introduced. Applications of biomaterials for tissue engineering in the vascular system, skeletal muscle, heart muscle, tendons and ligaments, bone, teeth, nerve and brain, and drug delivery systems are introduced. Fundamentals in medical implantology, in situ drug release, cell transplantation and stem cell biology are discussed. | ||||
| Lecture notes | Handouts provided during the classes and references therin. | ||||
| Literature | The molecular Biology of the Cell, Alberts et al., 5th Edition, 2009. Principles in Tissue Engineering, Langer et al., 2nd Edition, 2002 | ||||