Helma Wennemers: Catalogue data in Autumn Semester 2022
|Name||Prof. Dr. Helma Wennemers|
Lab. für Organische Chemie
ETH Zürich, HCI H 313
|Telephone||+41 44 633 37 77|
|Department||Chemistry and Applied Biosciences|
|529-0221-00L||Organic Chemistry I||3 credits||2V + 1U||H. Wennemers|
|Abstract||This course will build upon the basic knowledge of structure and reactivity of organic molecules gained in AC/OCI and AC/OCII. The module aims to provide a wide understanding of the occurrence, synthesis, properties, and reactivity of carbonyl compounds.|
|Objective||The goal of this course is the acquisition of a basic repertoire of synthetic methods including important reactions of aldehydes, ketones, carboxylic acids, and carboxylic acid derivatives. Particular emphasis is placed on the understanding of reaction mechanisms and the correlation between structure and reactivity. A deeper understanding of the concepts presented during the lecture is reached by solving the problems handed out each time and discussed one week later in the exercise class.|
|Content||Structure and properties of carbonyl compounds. Chemistry of aldehydes and ketones (hydrates, acetals, imines, enamines, nucleophilic addition of organometallic compounds). Synthesis and reactivity of carboxylic acid derivatives (nucleophilic addition-elimination reactions). Oxidations and reductions. Reactivity at the alpha-carbon (keto/enol tautomerization, alpha-functionalization, aldol reactions, conjugate addition reactions). Introduction to the concepts of protecting groups and retrosynthesis.|
|Lecture notes||The lecture slides, problem sets, and additional documents are provided online. Link: https://wennemers.ethz.ch/education.html|
|Literature||Clayden, Greeves, and Warren. Organic Chemistry, 2nd Edition. Oxford University Press, 2012. Additional literature will be provided at the beginning of the class and in the lecture notes.|
|529-0240-00L||Chemical Biology - Peptides||6 credits||3G||H. Wennemers|
|Abstract||An advanced course on the synthesis, properties and function of peptides in chemistry and biology.|
|Objective||Knowledge of the synthesis, properties and function of peptides in chemistry and biology.|
|Content||Advanced peptide synthesis, conformational properties, combinatorial chemistry, therapeutic peptides, peptide based materials, peptides in nanotechnology, peptides in asymmetric catalysis.|
|Lecture notes||Citations from the original literature relevant to the individual lectures will be assigned weekly.|
|Literature||Norbert Sewald, Hans Dieter Jakubke "Peptides: Chemistry and Biology", 1st edition, Wiley VCH, 2002.|
|529-0290-00L||Organic Chemistry (Seminar)||0 credits||2S||E. M. Carreira, J. W. Bode, H. Wennemers, R. Zenobi|
|529-0299-00L||Organic Chemistry||0 credits||1.5K||J. W. Bode, E. M. Carreira, P. Chen, H. Wennemers, R. Zenobi|
|529-0731-00L||Nucleic Acids and Carbohydrates|
Note for BSc Biology students: Only one of the two concept courses 529-0731-00 Nucleic Acids and Carbohydrates (autumn semester) or 529-0732-00 Proteins and Lipids (spring semester) can be counted for the Bachelor's degree.
|6 credits||3G||K. Lang, P. A. Kast, S. J. Sturla, H. Wennemers|
|Abstract||Structure, function and chemistry of nucleic acids and carbohydrates. DNA/RNA structure and synthesis; recombinant DNA technology and PCR; DNA arrays and genomics; antisense approach and RNAi; polymerases and transcription factors; catalytic RNA; DNA damage and repair; carbohydrate structure and synthesis; carbohydrate arrays; cell surface engineering; carbohydrate vaccines|
|Objective||Structure, function and chemistry of nucleic acids and carbohydrates. DNA/RNA structure and synthesis; recombinant DNA technology and PCR; DNA arrays and genomics; antisense approach and RNAi; polymerases and transcription factors; catalytic RNA; DNA damage and repair; carbohydrate structure and synthesis; carbohydrate arrays; cell surface engineering; carbohydrate vaccines|
|Content||Structure, function and chemistry of nucleic acids and carbohydrates. DNA/RNA structure and synthesis; recombinant DNA technology and PCR; DNA arrays and genomics; antisense approach and RNAi; polymerases and transcription factors; catalytic RNA; DNA damage and repair; carbohydrate structure and synthesis; carbohydrate arrays; cell surface engineering; carbohydrate vaccines|
|Lecture notes||No script; illustrations from the original literature relevant to the individual lectures will be provided weekly (typically as handouts downloadable from the Moodle server).|
|Literature||Mainly based on original literature, a detailed list will be distributed during the lecture|
|551-0357-00L||Cellular Matters: From Milestones to Open Questions|
The number of participants is limited to 22 and will only take place with a minimum of 11 participants.
Please sign up until two weeks before the beginning of the semester (for Autumn 2022: by 05.09.2022 end of day) via e-mail to firstname.lastname@example.org using in the subject: 551-0357-00. In the email body indicate 1) your name, 2) your e-mail address, 3) master/PhD program. The students admitted to this seminar will be informed by e-mail in the week prior to the beginning of the semester.
The first lecture will serve to form groups of students and assign papers.
|4 credits||2S||Y. Barral, F. Allain, P. Arosio, E. Dufresne, D. Hilvert, M. Jagannathan, R. Mezzenga, T. Michaels, G. Neurohr, R. Riek, A. E. Smith, K. Weis, H. Wennemers|
|Abstract||In this course, the students will explore the quite new topic of biomolecular condensates.|
Concepts and tools from biology, chemistry, biophysics and soft materials will be used, on one hand, to develop an understanding of the biological properties and functions of biomolecular condensates in health and disease, while, on the other, to inspire new materials.
|Objective||In terms of content, you, the student, after a general introduction to the topic, will learn about milestone works and current research questions in the young field of biomolecular condensates (properties, functions and applications) from an interdisciplinary point of view in a course which is a combination of literature (presentations given by pairs of students with different scientific backgrounds) and research seminars (presentations given by the lecturers all active experts in the field, with different backgrounds and expertise).|
As to the skills, you will have the opportunity to learn how to critically read and evaluate scientific literature, how to give scientific presentations to an interdisciplinary audience (each presentation consisting of an introduction, critical description of the results and discussion of their significance) and substantiate your statements, acquire a critical mindset (pros/cons of chosen approaches/methods and limitations, quality of the data, solidity of the conclusions, possible follow-up experiments) that allows you to ask relevant questions and actively participate to the discussion.
With the final presentation you will have the unique opportunity to interact closely with the interdisciplinary group of lecturers (all internationally well-established experts) who will guide you in the choice of a subtopic and related literature.
|Content||In the last decade a new kind of compartments within the cell, the so-called biomolecular condensates, have been observed. This discovery is radically changing our understanding of the cell, its organization and dynamics. The emerging picture is that the cytoplasm and nucleoplasm are highly complex fluids that can (meta)stably segregate into membrane-less sub-compartments, similarly to emulsions.|
The topic of biomolecular condensates goes beyond the boundaries of traditional disciplines and needs a multi-pronged approach that levers on, and cross-fertilizes, biology, physical chemistry, biophysics and soft materials to develop a proper understanding of the properties, functions in health and disease (Alzheimer’s, Parkinson’s, etc.), as well as possible applications of these biomolecular condensates.
Each week the lecture will consist of:
1) a short literature seminar: Pairs of students from different scientific backgrounds will be formed and assigned beforehand to present milestone literature to the class and facilitate the ensuing discussion. In the first class the pairs will be formed, the milestone papers made known to the whole class and assigned to the pairs.
2) a research seminar: the presentation of the milestone literature will serve as the introduction to the lecture by one of the lecturers of the course on their own state-of-the-art research in the field.
|Lecture notes||The presentations will be made available after the lectures.|
|Literature||The milestone papers will be provided in advance.|
For the final examination, the students will be helped by the lecturers in identifying a research topic and related literature.