Helma Wennemers: Katalogdaten im Herbstsemester 2022 |  |
| Name | Frau Prof. Dr. Helma Wennemers |
| Lehrgebiet | Organische Chemie |
| Adresse | Lab. für Organische Chemie ETH Zürich, HCI H 313 Vladimir-Prelog-Weg 1-5/10 8093 Zürich SWITZERLAND |
| Telefon | +41 44 633 37 77 |
| helma.wennemers@org.chem.ethz.ch | |
| Departement | Chemie und Angewandte Biowissenschaften |
| Beziehung | Ordentliche Professorin |
| Nummer | Titel | ECTS | Umfang | Dozierende | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 529-0221-00L | Organische Chemie I | 3 KP | 2V + 1U | H. Wennemers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | Dieser Kurs baut auf den in AC/OCI und AC/OCII erworbenen Grundkenntnissen über Struktur und Reaktivität organischer Moleküle auf. Im Rahmen des Moduls soll ein breites Verständnis des Vorkommens, der Synthese, der Eigenschaften und der Reaktivität von Carbonylverbindungen vermittelt werden. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | Ziel dieses Kurses ist die Aneignung eines grundlegenden Repertoires an Synthesemethoden einschließlich wichtiger Reaktionen von Aldehyden, Ketonen, Carbonsäuren und Carbonsäurederivaten. Besonderer Wert wird auf das Verständnis von Reaktionsmechanismen und den Zusammenhang zwischen Struktur und Reaktivität gelegt. Ein vertieftes Verständnis der in der Vorlesung vorgestellten Konzepte wird durch das Lösen von spezifischen Aufgaben, die eine Woche später in der Übung besprochen werden, erreicht. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | Struktur und Eigenschaften von Carbonylverbindungen. Chemie der Aldehyde und Ketone (Hydrate, Acetale, Imine, Enamine, nucleophile Addition metallorganischer Verbindungen). Synthese und Reaktivität von Carbonsäurederivaten (nucleophile Additions-Eliminierungs-Reaktionen). Oxidationen und Reduktionen. Reaktivität am alpha-Kohlenstoff (Keto/Enol-Tautomerisierung, alpha-Funktionalisierung, Aldolreaktionen, konjugierte Additionsreaktionen). Einführung in die Konzepte von Schutzgruppen und Retrosynthese. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Skript | Die Vorlesungsfolien, Übungsaufgaben und weitere Dokumente werden online bereitgestellt. Link: https://wennemers.ethz.ch/education.html | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literatur | Clayden, Greeves und Warren. Organische Chemie, 2. Auflage. Oxford University Press, 2012. Weitere Literatur wird zu Beginn der Vorlesung und im Skript zur Verfügung gestellt. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-0240-00L | Chemical Biology - Peptides | 6 KP | 3G | H. Wennemers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | An advanced course on the synthesis, properties and function of peptides in chemistry and biology. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | Knowledge of the synthesis, properties and function of peptides in chemistry and biology. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | Advanced peptide synthesis, conformational properties, combinatorial chemistry, therapeutic peptides, peptide based materials, peptides in nanotechnology, peptides in asymmetric catalysis. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Skript | Citations from the original literature relevant to the individual lectures will be assigned weekly. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literatur | Norbert Sewald, Hans Dieter Jakubke "Peptides: Chemistry and Biology", 1st edition, Wiley VCH, 2002. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-0290-00L | Organic Chemistry (Seminar)  | 0 KP | 2S | E. M. Carreira, J. W. Bode, H. Wennemers, R. Zenobi | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 529-0299-00L | Organic Chemistry | 0 KP | 1.5K | J. W. Bode, E. M. Carreira, P. Chen, H. Wennemers, R. Zenobi | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Lernziel | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-0731-00L | Nucleic Acids and Carbohydrates Hinweis für BSc Biologiestudierende: Nur einer der beiden Konzeptkurse 529-0731-00 Nucleic Acids and Carbohydrates (Herbstsemester) oder 529-0732-00 Proteins and Lipids (Frühlingsemester) kann für das Bachelorstudium angerechnet werden. | 6 KP | 3G | K. Lang, P. A. Kast, S. J. Sturla, H. Wennemers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | Struktur, Funktion und Chemie von Nukleinsäuren und Kohlenhydraten. DNA/RNA Struktur und Synthese; rekombinante DNA Technologie und PCR; DNA Arrays und Genomics; Antisense Ansatz und RNAi; Polymerasen und Transkriptionsfaktoren; katalytische RNA; DNA Schädigung und Reparatur; Kohlenhydratstruktur und Synthese; Kohlenhydratarrays; Cell Surface Engineering; Kohlenhydratimpfstoffe | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | Struktur, Funktion und Chemie von Nukleinsäuren und Kohlenhydraten. DNA/RNA Struktur und Synthese; rekombinante DNA Technologie und PCR; DNA Arrays und Genomics; Antisense Ansatz und RNAi; Polymerasen und Transkriptionsfaktoren; katalytische RNA; DNA Schädigung und Reparatur; Kohlenhydratstruktur und Synthese; Kohlenhydratarrays; Cell Surface Engineering; Kohlenhydratimpfstoffe | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | Struktur, Funktion und Chemie von Nukleinsäuren und Kohlenhydraten. DNA/RNA Struktur und Synthese; rekombinante DNA Technologie und PCR; DNA Arrays und Genomics; Antisense Ansatz und RNAi; Polymerasen und Transkriptionsfaktoren; katalytische RNA; DNA Schädigung und Reparatur; Kohlenhydratstruktur und Synthese; Kohlenhydratarrays; Cell Surface Engineering; Kohlenhydratimpfstoffe | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Skript | Kein Skript; Illustrationen aus der Originalliteratur passend zu den behandelten Themen werden wöchentlich zur Verfügung gestellt (in der Regel als Handouts auf dem Moodle Server). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literatur | Hauptsächlich basierend auf Originalliteratur, eine detaillierte Liste wird in der Vorlesung ausgeteilt | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Kompetenzen |
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| 551-0357-00L | Cellular Matters: From Milestones to Open Questions The number of participants is limited to 22 and will only take place with a minimum of 11 participants. Please sign up until two weeks before the beginning of the semester (for Autumn 2022: by 05.09.2022 end of day) via e-mail to bml@ethz.ch using in the subject: 551-0357-00. In the email body indicate 1) your name, 2) your e-mail address, 3) master/PhD program. The students admitted to this seminar will be informed by e-mail in the week prior to the beginning of the semester. The first lecture will serve to form groups of students and assign papers. | 4 KP | 2S | Y. Barral, F. Allain, P. Arosio, E. Dufresne, D. Hilvert, M. Jagannathan, R. Mezzenga, T. Michaels, G. Neurohr, R. Riek, A. E. Smith, K. Weis, H. Wennemers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | In this course, the students will explore the quite new topic of biomolecular condensates. Concepts and tools from biology, chemistry, biophysics and soft materials will be used, on one hand, to develop an understanding of the biological properties and functions of biomolecular condensates in health and disease, while, on the other, to inspire new materials. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | In terms of content, you, the student, after a general introduction to the topic, will learn about milestone works and current research questions in the young field of biomolecular condensates (properties, functions and applications) from an interdisciplinary point of view in a course which is a combination of literature (presentations given by pairs of students with different scientific backgrounds) and research seminars (presentations given by the lecturers all active experts in the field, with different backgrounds and expertise). As to the skills, you will have the opportunity to learn how to critically read and evaluate scientific literature, how to give scientific presentations to an interdisciplinary audience (each presentation consisting of an introduction, critical description of the results and discussion of their significance) and substantiate your statements, acquire a critical mindset (pros/cons of chosen approaches/methods and limitations, quality of the data, solidity of the conclusions, possible follow-up experiments) that allows you to ask relevant questions and actively participate to the discussion. With the final presentation you will have the unique opportunity to interact closely with the interdisciplinary group of lecturers (all internationally well-established experts) who will guide you in the choice of a subtopic and related literature. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | In the last decade a new kind of compartments within the cell, the so-called biomolecular condensates, have been observed. This discovery is radically changing our understanding of the cell, its organization and dynamics. The emerging picture is that the cytoplasm and nucleoplasm are highly complex fluids that can (meta)stably segregate into membrane-less sub-compartments, similarly to emulsions. The topic of biomolecular condensates goes beyond the boundaries of traditional disciplines and needs a multi-pronged approach that levers on, and cross-fertilizes, biology, physical chemistry, biophysics and soft materials to develop a proper understanding of the properties, functions in health and disease (Alzheimer’s, Parkinson’s, etc.), as well as possible applications of these biomolecular condensates. Each week the lecture will consist of: 1) a short literature seminar: Pairs of students from different scientific backgrounds will be formed and assigned beforehand to present milestone literature to the class and facilitate the ensuing discussion. In the first class the pairs will be formed, the milestone papers made known to the whole class and assigned to the pairs. 2) a research seminar: the presentation of the milestone literature will serve as the introduction to the lecture by one of the lecturers of the course on their own state-of-the-art research in the field. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Skript | The presentations will be made available after the lectures. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literatur | The milestone papers will be provided in advance. For the final examination, the students will be helped by the lecturers in identifying a research topic and related literature. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kompetenzen |
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