Helma Wennemers: Catalogue data in Autumn Semester 2019 |  |
| Name | Prof. Dr. Helma Wennemers |
| Field | Organic Chemistry |
| Address | Lab. für Organische Chemie ETH Zürich, HCI H 313 Vladimir-Prelog-Weg 1-5/10 8093 Zürich SWITZERLAND |
| Telephone | +41 44 633 37 77 |
| helma.wennemers@org.chem.ethz.ch | |
| Department | Chemistry and Applied Biosciences |
| Relationship | Full Professor |
| Number | Title | ECTS | Hours | Lecturers | |
|---|---|---|---|---|---|
| 529-0221-00L | Organic Chemistry I | 3 credits | 2V + 1U | H. Wennemers | |
| Abstract | Chemical reactivity and classes of compounds. Eliminations, fragmentations, chemistry of aldehydes and ketones (hydrates, acetals, imines, enamines, nucleophilic addition of organometallic compounds, reactions with phosphorus and sulfur ylides; reactions of enolates as nucleophiles) and of carboxylic acid derivatives. Aldol reactions. | ||||
| Learning objective | Acquisition of a basic repertoire of synthetic methods including important reactions of aldehydes, ketones, carboxylic acids and carboxylic acid derivatives, as well as eliminations and fragmentations. Particular emphasis is placed on the understanding of reaction mechanisms and the correlation between structure and reactivity. A deeper understanding of the concepts presented during the lecture is reached by solving the problems handed out each time and discussed one week later in the exercise class. | ||||
| Content | Chemical reactivity and classes of compounds. Eliminations, fragmentations, chemistry of aldehydes and ketones (hydrates, acetals, imines, enamines, nucleophilic addition of organometallic compounds, reactions with phosphorus and sulfur ylides; reactions of enolates as nucleophiles) and of carboxylic acid derivatives. Aldol reactions. | ||||
| Lecture notes | A pdf file of the printed lecture notes is provided online. Supplementary material may be provided online. | ||||
| Literature | No set textbooks. Optional literature will be proposed at the beginning of the class and in the lecture notes. | ||||
| 529-0240-00L | Chemical Biology - Peptides | 6 credits | 3G | H. Wennemers | |
| Abstract | An advanced course on the synthesis, properties and function of peptides in chemistry and biology. | ||||
| Learning objective | Knowledge of the synthesis, properties and function of peptides in chemistry and biology. | ||||
| Content | Advanced peptide synthesis, conformational properties, combinatorial chemistry, therapeutic peptides, peptide based materials, peptides in nanotechnology, peptides in asymmetric catalysis. | ||||
| Lecture notes | Citations from the original literature relevant to the individual lectures will be assigned weekly. | ||||
| Literature | Norbert Sewald, Hans Dieter Jakubke "Peptides: Chemistry and Biology", 1st edition, Wiley VCH, 2002. | ||||
| 529-0290-00L | Organic Chemistry (Seminar)  | 0 credits | 2S | E. M. Carreira, J. W. Bode, D. Hilvert, H. Wennemers, R. Zenobi | |
| Abstract | |||||
| Learning objective | |||||
| 529-0299-00L | Organic Chemistry | 0 credits | 1.5K | J. W. Bode, E. M. Carreira, P. Chen, D. Hilvert, H. Wennemers, R. Zenobi | |
| Abstract | |||||
| Learning objective | |||||
| 529-0731-00L | Nucleic Acids and Carbohydrates Note for BSc Biology students: Only one of the two concept courses 529-0731-00 Nucleic Acids and Carbohydrates (autumn semester) or 529-0732-00 Proteins and Lipids (spring semester) can be counted for the Bachelor's degree. | 6 credits | 3G | D. Hilvert, P. A. Kast, S. J. Sturla, H. Wennemers | |
| Abstract | Structure, function and chemistry of nucleic acids and carbohydrates. DNA/RNA structure and synthesis; recombinant DNA technology and PCR; DNA arrays and genomics; antisense approach and RNAi; polymerases and transcription factors; catalytic RNA; DNA damage and repair; carbohydrate structure and synthesis; carbohydrate arrays; cell surface engineering; carbohydrate vaccines | ||||
| Learning objective | Structure, function and chemistry of nucleic acids and carbohydrates. DNA/RNA structure and synthesis; recombinant DNA technology and PCR; DNA arrays and genomics; antisense approach and RNAi; polymerases and transcription factors; catalytic RNA; DNA damage and repair; carbohydrate structure and synthesis; carbohydrate arrays; cell surface engineering; carbohydrate vaccines | ||||
| Content | Structure, function and chemistry of nucleic acids and carbohydrates. DNA/RNA structure and synthesis; recombinant DNA technology and PCR; DNA arrays and genomics; antisense approach and RNAi; polymerases and transcription factors; catalytic RNA; DNA damage and repair; carbohydrate structure and synthesis; carbohydrate arrays; cell surface engineering; carbohydrate vaccines | ||||
| Lecture notes | No script; illustrations from the original literature relevant to the individual lectures will be provided weekly (typically as handouts downloadable from the Moodle server). | ||||
| Literature | Mainly based on original literature, a detailed list will be distributed during the lecture | ||||