Marc-Olivier Ebert: Catalogue data in Spring Semester 2018

Name	Dr. Marc-Olivier Ebert
Address	Lab. für Organische Chemie ETH Zürich, HCI E 315 Vladimir-Prelog-Weg 1-5/10 8093 Zürich SWITZERLAND
Telephone	+41 44 633 47 26
Fax	+41 44 632 14 75
E-mail	marc-olivier.ebert@org.chem.ethz.ch
Department	Chemistry and Applied Biosciences
Relationship	Lecturer

Number	Title	ECTS	Hours	Lecturers
529-0042-00L	Structure Elucidation by NMR	4 credits	2G	M.‑O. Ebert
Abstract	Structure Elucidation of Complex Organic Molecules by NMR
Learning objective	Structure elucidation of complex organic molecules (including peptides, oligosaccharides and oligonucleotides) by advanced 1D and 2D NMR spectroscopy. The emphasis of the course is on the selection of optimal strategies for the solution of a given problem, spectrum interpretation and possible artifacts. Solving and discussing practical case studies/problems demonstrating the individual methods and, in the last third of the course, the combined application of several methods form an important part of the course.
Content	Structure determination by multi-pulse and 2D NMR spectroscopy. Homonuclear and heteronuclear shift correlation through scalar coupling; one and two dimensional methods based on the nuclear Overhauser effect. Choosing the best strategy for a given problem, interpretation and artefacts.
Lecture notes	Scripts (in English) are distributed in the course
Literature	T.D.W. Claridge, High Resolution NMR Techniques in Organic Chemistry, Pergamon Press, 1999 (NMR part) Further reading and citations are listed in the script.
Prerequisites / Notice	The course language is English. Required level: Courses in analytical chemistry of the 2nd year or equivalent.
529-0054-00L	Physical and Analytical Chemistry	10 credits	15P	E. C. Meister, R. Zenobi, M. Badertscher, M.‑O. Ebert, B. Hattendorf
Abstract	Practical introduction to important experimental methods in physical and analytical chemistry.
Learning objective	The students have to carry out selected experiments in physical chemistry and evaluate measurement data. They acquire a good knowledge about the most important practical techniques in analytical chemistry. Laboratory reports have to be written to each experiment.
Content	Physical chemistry part: Short recapitulation of statistics and analysis of measurement data. Writing experimental reports with regard to publication of scientific works. Basic physical chemistry experiments (a maximum of six experiments form the following themes): 1. Phase diagrams (liquid-vapour and solid-liquid phase diagrams, cryoscopy); 2. electrochemistry and electronics; 3. quantum chemistry studies; 4. kinetics; 5. thermochemistry; 6. speed of sound in gases and liquids; 7. surface tension. Analytical chemistry part: 1. Introduction to the concept of sampling, quantitative elemental analysis and trace analysis, atomic spectroscopic methods, comparative measurements with electrochemical methods; 2. Separation methods, their principles and optimisation: comparison of the different chromatographic methods, effect of the stationary and mobile phases, common errors/artefacts, liquid chromatography, gas chromatography (injection methods). 3. Spectroscopic methods in organic structure determination: recording of IR and UV/VIS spectra, recording technique in NMR Mandatory exercises in spectroscopy in an accompanying tutorial 529-0289-00 "Instrumentalanalyse organischer Verbindungen" are an integral part of this course.
Lecture notes	Descriptions for experiments available online.
Literature	Für PC-Teil: Erich Meister, Grundpraktikum Physikalische Cheme, 2. Aufl. Vdf UTB, Zürich 2012.
Prerequisites / Notice	Prerequisites: 529-0051-00 "Analytische Chemie I (3. Semester)" 529-0058-00 "Analytische Chemie II (4. Semester)" in parallel to the lab class, or completed in an earlier semester. The course 529-0289-00L "Instumentalanalyse organischer Verbindungen" is an obligatory component of the lab class / praktikum.
529-0058-AAL	Analytical Chemistry II Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement. Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit.	3 credits	6R	D. Günther, M.‑O. Ebert, P. Lienemann, G. Schwarz, R. Zenobi
Abstract	Enhanced knowledge about the elemental analysis and spectrocopical techniques with close relation to practical applications. This course is based on the knowledge from analytical chemistry I. Separation methods are included.
Learning objective	Use and applications of the elemental analysis and spectroscopical knowledge to solve relevant analytical problems.
Content	Combined application of spectroscopic methods for structure determination, and practical application of element analysis. More complex NMR methods: recording techniques, application of exchange phenomena, double resonance, spin-lattice relaxation, nuclear Overhauser effect, applications of experimental 2d and multipulse NMR spectroscopy, shift reagents. Application of chromatographic and electrophoretic separation methods: basics, working technique, quality assessment of a separation method, van-Deemter equation, gas chromatography, liquid chromatography (HPLC, ion chromatography, gel permeation, packing materials, gradient elution, retention index), electrophoresis, electroosmotic flow, zone electrophoresis, capillary electrophoresis, isoelectrical focussing, electrochromatography, 2d gel electrophoresis, SDS-PAGE, field flow fractionation, enhanced knowledge in atomic absorption spectroscopy, atomic emission spectroscopy, X-ray fluorescence spectroscopy, ICP-OES, ICP-MS.
Literature	general: R. Kellner, J.-M. Mermet, M. Otto, H. M. Widmer (Eds.) Analytical Chemistry, Wiley-VCH, Weinheim, 1998; XRF: R. Schramm, X-Ray Fluorescence Analysis: Practical and Easy, Fluxana, Kleve, 2012; ICP-MS: R. Thomas, Practical Guide to ICP-MS - A Tutorial for beginners, 3rd Edition, CRC Press, Taylor & Francis Group, Boca Raton, 2013 (especially: chapters 1-15, 19 and 21). Separation methods: S. Ahuja (Ed.), Chromatography and Separation Science, Volume 4 of series "Separation Science and Technology", Elsevier Academic Press, San Diego, 2003. K. Robards, P. R. Haddad, and P. E. Jackson, Principle and Practise of Modern Chromatographic Methods, Academic Press, London, 1994. F. Foret, L. Krivankova, and P. Bocek, Capillary Zone Electrophoresis, VCH, Weinheim (1993)
Prerequisites / Notice	None.
529-0058-00L	Analytical Chemistry II	3 credits	3G	D. Günther, T. Bucheli, M.‑O. Ebert, P. Lienemann, G. Schwarz
Abstract	Enhanced knowledge about the elemental analysis and spectrocopical techniques with close relation to practical applications. This course is based on the knowledge from analytical chemistry I. Separation methods are included.
Learning objective	Use and applications of the elemental analysis and spectroscopical knowledge to solve relevant analytical problems.
Content	Combined application of spectroscopic methods for structure determination, and practical application of element analysis. More complex NMR methods: recording techniques, application of exchange phenomena, double resonance, spin-lattice relaxation, nuclear Overhauser effect, applications of experimental 2d and multipulse NMR spectroscopy, shift reagents. Application of chromatographic and electrophoretic separation methods: basics, working technique, quality assessment of a separation method, van-Deemter equation, gas chromatography, liquid chromatography (HPLC, ion chromatography, gel permeation, packing materials, gradient elution, retention index), electrophoresis, electroosmotic flow, zone electrophoresis, capillary electrophoresis, isoelectrical focussing, electrochromatography, 2d gel electrophoresis, SDS-PAGE, field flow fractionation, enhanced knowledge in atomic absorption spectroscopy, atomic emission spectroscopy, X-ray fluorescence spectroscopy, ICP-OES, ICP-MS.
Lecture notes	Script will be available
Literature	Literature will be within the script.
Prerequisites / Notice	Exercises for spectra interpretation are part of the lecture. In addition the lecture 529-0289-00 "Instrumentalanalyse organischer Verbindungen" (4th semester) is recommended. Prerequisite: 529-0051-00 "Analytische Chemie I" (3rd semester)