Bernd Wollscheid: Katalogdaten im Frühjahrssemester 2021

Name	Herr Prof. Dr. Bernd Wollscheid
Adresse	Dep. Gesundheitswiss. und Technol. ETH Zürich, HPM H 27 Otto-Stern-Weg 3 8093 Zürich SWITZERLAND
Telefon	+41 44 633 36 84
E-Mail	bernd.wollscheid@hest.ethz.ch
Departement	Gesundheitswissenschaften und Technologie
Beziehung	Titularprofessor

Nummer	Titel	ECTS	Umfang	Dozierende
551-0324-00L	Systems Biology	6 KP	4V	P. Picotti, M. Claassen, U. Sauer, B. Snijder, B. Wollscheid
Kurzbeschreibung	Introduction to experimental and computational methods of systems biology. By using baker’s yeast as a thread through the series, we focus on global methods for analysis of and interference with biological functions. Illustrative applications to other organisms will highlight medical and biotechnological aspects.
Lernziel	- obtain an overview of global analytical methods - obtain an overview of computational methods in systems biology - understand the concepts of systems biology
Inhalt	Overview of global analytical methods (e.g. DNA arrays, proteomics, metabolomics, fluxes etc), global interference methods (siRNA, mutant libraries, synthetic lethality etc.) and imaging methods. Introduction to mass spectrometry and proteomics. Concepts of metabolism in microbes and higher cells. Systems biology of developmental processes. Concepts of mathematical modeling and applications of computational systems biology.
Skript	no script
Literatur	The course is not taught by a particular book, but some books are suggested for further reading: - Systems biology in Practice by Klipp, Herwig, Kowald, Wierling und Lehrach. Wiley-VCH 2005
551-0362-00L	Molecular Health: Biomedical Analysis of the Extracellular Interactome Number of participants limited to 12. The enrolment is done by the D-BIOL study administration. General safety regulations for all block courses: -Whenever possible the distance rules have to be respected -All students have to wear masks throughout the course. Please keep reserve masks ready. Surgical masks (IIR) or medical grade masks (FFP2) without a valve are permitted. Community masks (fabric masks) are not allowed. -The installation and activation of the Swiss Covid-App is highly encouraged -Any additional rules for individual courses have to be respected -Students showing any COVID-19 symptoms are not allowed to enter ETH buildings and have to inform the course responsible	6 KP	7P	B. Wollscheid, E. Tschudy-Milani
Kurzbeschreibung	In this course you will learn to measure, integrate, analyze and validate the cellular surfaceome as a complex information gateway connecting the intracellular to the extracellular interactome. You will apply next generation technologies at the interface of biology, chemistry, medicine and bioinformatics to establish the surfaceome proteotype and its signaling interaction networks.
Lernziel	"If a cell surface molecule such as the B cell receptor would have the size of a human being, then the cell surface of a B cell would have roughly the size of three times NYC Central Park." How many people/proteins/proteoforms reside in this space ("Surfaceome")? Similar to humans, proteins don't act alone. Function is encoded in dynamic protein-protein interactions. How are these proteoforms organized in signaling islands/networks in order to fulfill specific cellular functions ("Interactome")? What are the ligands interacting with the surfaceome to communicate information from other cells & tissues in the body? What goes wrong in these signaling islands if we get sick? In this course you will learn to measure, integrate, analyze and validate the cellular surfaceome and its signaling islands as a complex information gateway connecting the intracellular to the extracellular interactome. You will apply next generation technologies at the interface of biology, chemistry, medicine and bioinformatics to generate unprecedented data to establish the surfaceome proteotype and its signaling interaction networks. This digital proteotype data layer provides the basis for generating qualitative and quantitative surfaceome models explaining how molecular nanoscale organization influences cellular signaling and biological function.
Inhalt	"If a cell surface molecule such as the B cell receptor would have the size of a human being, then the cell surface of a B cell would have roughly the size of three times NYC Central Park." How many people/proteins/proteoforms reside in this space ("Surfaceome")? Similar to humans, proteins don't act alone. Function is encoded in dynamic protein-protein interactions. How are these proteoforms organized in signaling islands/networks in order to fulfill specific cellular functions ("Interactome")? What are the ligands interacting with the surfaceome to communicate information from other cells & tissues in the body? What goes wrong in these signaling islands if we get sick? In this course you will learn to measure, integrate, analyze and validate the cellular surfaceome and its signaling islands as a complex information gateway connecting the intracellular to the extracellular interactome. You will apply next generation technologies at the interface of biology, chemistry, medicine and bioinformatics to generate unprecedented data to establish the surfaceome proteotype and its signaling interaction networks. This digital proteotype data layer provides the basis for generating qualitative and quantitative surfaceome models explaining how molecular nanoscale organization influences cellular signaling and biological function.
Literatur	D. Bausch-Fluck, E. S. Milani, B. Wollscheid, Surfaceome nanoscale organization and extracellular interaction networks, Curr. Opin. Chem. Biol. 48, 26–33 (2019). https://paperpile.com/shared/ud6iWG
Voraussetzungen / Besonderes	This course requires a basic knowledge in mass spectrometry based proteomics and experience in computational data processing using R or MatLab. Ideally this course should be combined with course 551-0352-00L "Introduction to Mass Spectrometry-based Proteomics".
551-1304-00L	Biochemie Nur für Gesundheitswissenschaften und Technologie BSc und Humanmedizin BSc.	3 KP	3V	U. K. Genick, M. Peter, B. Wollscheid
Kurzbeschreibung	Der Kurs vermittelt Studierenden die zentralen Fakten und Konzepte der Biochemie und behandelt Themen aus den Bereichen Struktur, physico-chemischen Eigenschaften und Funktion von Biomolekülen; Enzyme und deren Funktionsweise; menschlicher Stoffwechsel und dessen Regulation; Signaltransduktion und Motorproteine.
Lernziel	Die detaillierten Lernziele finden Sie auf der Moodle Seite des Kurses.
Skript	Der Kurs hat kein traditionelles Skript sondern wird durch eine Moodle Seite unterstützt über die Studierende Zugang zu Unterlagen, Aufgaben, Videos und Aktivitäten haben.
Literatur	Die essenziellen Dokumente des Kurses werden in form von Skripten und Lektionen auf der Moodle Seite des Kurses zur Verfügung gestellt. Für den Kurs gibt es kein "offizielles" Lehrbuch, doch Studierende die ein generelles Nachschlagwerk zum Thema suchen oder sich vertieft mit dem Thema geschäftigen wollen könnten sich für "Löffler/Petrides Biochemie und Pathobiochemie" ISBN 978-3-642-17971-6 interessieren.
Voraussetzungen / Besonderes	Der Kurs baut auf den Inhalten der Lehrveranstaltungen "Chemie für Mediziner" und "Molekulare Genetik und Zellbiologie" auf.